Protein Alignment EcR and nhr-131

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_503221.2
• Gene: nhr-131 / 187962
• WormBaseID: WBGene00003721
• Length: 403
• Species: Caenorhabditis elegans
• Alignment Length: 359
• Identity: 69/359 - (19%)
• Similarity: 127/359 - (35%)
• Gaps: 109/359 - (30%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTK--SAVYCCKFGRACEMDMYMRRKCQECRLKKCLA 326
            |::||....|:|:..::|..|..||||:...  |.:.|  ..:.|:...|   .|:.||||||..
 Worm    10 CIICGQNGQGHHFGVISCRACAAFFRRAADSKWSRMKC--LSKYCDGKTY---HCKPCRLKKCRD 69

  Fly   327 VGMRPECVVPEN---QCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMT 388
            |||.......:.   |.....|::|..:..|.:.:.|:...             |..::..||..
 Worm    70 VGMDVSKFQHDRDALQIVHPNRKRKLAQLADPIFSEPNFVF-------------FFPQDREDLKL 121

  Fly   389 CEPPQHATIPLLPDE------------ILAKCQARNI-----------------------PSLT- 417
            .:...:..:.||..:            ::||.|.:.:                       ..:|
 Worm   122 KKKNTYVDLSLLVSQAMEIIKTGPETPLVAKNQLQKLNFGFNCMKHTGIANFQRIHLVTRKEVTG 186

  Fly   418 ---YNQLAVIYKLIWYQDGYEQPSEEDLRRIM---------------------SQPDENESQTDV 458
               |:.||.. |.:.|.|.::|..::..|:|:                     ...:.:.|...|
 Worm   187 FWEYHMLASA-KWLTYFDEFQQLDQDVKRKILFGVWHVWGRLDKLMGTALFRIKNKEASLSDRVV 250

  Fly   459 SFRHITEITI----------LTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEV--MMLRMARR 511
            ....:|::..          |.||.:..|..|:.|:...|..|::..|....:|:  |:.::..:
 Worm   251 GNGIVTDMNCVVAETKWMSRLPVQQLRYFIDGIRAWDLFPLIDELQALDITETELSFMLAQLCFQ 315

  Fly   512 YDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLL 545
            |             :.||...|:|.:.:...|:|
 Worm   316 Y-------------AATRFGGKIAEVMEKFMDIL 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	28/91 (31%)
		NR_LBD_EcR	420..652	CDD:132736	29/159 (18%)
nhr-131	NP_503221.2	ZnF_C4	9..73	CDD:197701	24/67 (36%)
		Hormone_recep	172..371	CDD:459675	31/179 (17%)