Protein Alignment EcR and nhr-199

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_506905.1
• Gene: nhr-199 / 187058
• WormBaseID: WBGene00010604
• Length: 405
• Species: Caenorhabditis elegans
• Alignment Length: 446
• Identity: 89/446 - (19%)
• Similarity: 153/446 - (34%)
• Gaps: 168/446 - (37%)

  Fly   235 SSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDRASGYHYN-ALTCEGCKGFFRRSVTKSAVY 298
            :::...|:||          |.|     .||:|.:.|.|.|:. |..|..|..||||:|..:.::
 Worm     9 NNIGSASSNE----------PIP-----YCLICSEVADGNHFGVAAACRACAAFFRRTVQHNKIH 58

  Fly   299 CCKFGR-------ACE----------MDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRRE 346
            .|  ||       :|:          :....|..|:.||..|||.:||:...|       .:|||
 Worm    59 EC--GRNGQCFFLSCKFLLVGFQISPLSSDARSMCKACRYGKCLEMGMQRSSV-------QQRRE 114

  Fly   347 KKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKK-----EILDLMTCEPPQHATIPLLPDEILA 406
                            |.|...:::...|:..:.|     |:|                   ||.
 Worm   115 ----------------QLGKRLNISDDRGKPVLNKLRRAYEML-------------------ILN 144

  Fly   407 KCQARN--------------IPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTD 457
            :....|              :|.:..|:...||:.:|  :.:.:.|       |..||     |.
 Worm   145 RKHVHNRRENQAPRAIGFNELPIVFQNESTSIYQFLW--EAFPEYS-------MLLPD-----TK 195

  Fly   458 VSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSE---VMMLRMARRYDHSSDSI 519
            ::|                |.....:|......     ...||::   ||::       .|.|.|
 Worm   196 LAF----------------FKNFFLSFCLFESS-----FNGCSAKQKNVMLI-------PSGDYI 232

  Fly   520 FFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSM--------KVDNVEYALLTAIVI------- 569
            ..|::.|:..:.::.....||||.|....:.:.|.        .||..|:..|..|::
 Worm   233 DLAHSESFFTNDHQTFTERDNIEILAQRLKLIQSSITVPLSAENVDIYEFLALAGIILLESDSES 297

  Fly   570 ---FSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELR 622
               |.:.....|:.:::.:..:| ..:.||       |..::...| :||||..::
 Worm   298 EADFQEEAVKIKSNIIKDLLFHY-QCINIY-------DDAAMRLGA-VLSILPSIQ 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	31/107 (29%)
		NR_LBD_EcR	420..652	CDD:132736	42/224 (19%)
nhr-199	NP_506905.1	NR_DBD_like	23..114	CDD:413390	29/99 (29%)
		HOLI	184..344	CDD:214658	39/208 (19%)