Protein Alignment EcR and nhr-198

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_506903.2
• Gene: nhr-198 / 187056
• WormBaseID: WBGene00010603
• Length: 378
• Species: Caenorhabditis elegans
• Alignment Length: 380
• Identity: 85/380 - (22%)
• Similarity: 129/380 - (33%)
• Gaps: 96/380 - (25%)

  Fly   262 ELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLA 326
            |.|::|...|.|.:|.||||..||.|||||..|...|.||....|.:   .:|||:.||.:|||.
 Worm    20 EKCVICFGSALGMNYGALTCSACKMFFRRSAEKKLSYNCKKDNQCSI---AQRKCRACRFQKCLN 81

  Fly   327 VGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEP 391
            .||                                :.:...|.||........|.|:|
 Worm    82 FGM--------------------------------TFYSFRGQLAQNFNNLDQKLELL------- 107

  Fly   392 PQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQT 456
                                 :..||........|.|.|... |.||..|:.: .|...:.:.:|
 Worm   108 ---------------------LKELTIKDGKNYTKFINYYSN-EDPSLVDVLK-NSNVMKMKKRT 149

  Fly   457 DVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLK------ACSSEVMMLRMARR---Y 512
            ..:.....:...|.:...:.:........|:...|::.|.|      .|.:|.|....|:|   .
 Worm   150 PHTVTDSHDWAFLGIHARISYFMDFEFINKLSLNDKVILFKYNALRMGCMTEAMRCFTAKRAYLV 214

  Fly   513 DHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFSDRPGL- 576
            ..|.:.::..   .:.|...|...:.|....::.:  :...:.:.|.|..||.  :||...|.:
 Worm   215 TPSGEDVYLP---IFRRIFEKTPALLDQTSCMVLY--KFIELNITNEECILLA--LIFFCNPAIS 272

  Fly   577 ----EKA-QLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGN 626
                ||| :.:...|..|...|..|..:. |..|..        |.||:|.:|.|
 Worm   273 DELSEKAKETLSRHQKRYCSALLQYCQST-CQKSAP--------SRLTDLLSLYN 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	32/88 (36%)
		NR_LBD_EcR	420..652	CDD:132736	45/222 (20%)
nhr-198	NP_506903.2	ZnF_C4	21..85	CDD:197701	31/98 (32%)
		HOLI	160..319	CDD:214658	36/175 (21%)