Protein Alignment EcR and nhr-197

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_506901.1
• Gene: nhr-197 / 187055
• WormBaseID: WBGene00010602
• Length: 340
• Species: Caenorhabditis elegans
• Alignment Length: 384
• Identity: 78/384 - (20%)
• Similarity: 150/384 - (39%)
• Gaps: 93/384 - (24%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVG 328
            |:||..||:..:|.|::|..||.||.|:|.|:.::.||..:.|.:...:..||:.||.:|||.||
 Worm     3 CVVCSGRATNRNYGAMSCFACKMFFHRTVYKNLLFRCKRIQNCTIHFKIFPKCRACRFQKCLIVG 67

  Fly   329 MRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQ 393
                                       ||.:|.:    :|.::.|...|:...::||.:..:..:
 Worm    68 ---------------------------MTLAPLN----DGIVSIGNQSDYSYAKLLDDLKFKNDK 101

  Fly   394 HATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDL---RRIMSQPDENESQ 455
            :                       |:.....|.|       |.||..|:   |.||    :...:
 Worm   102 N-----------------------YSHFVNFYSL-------EDPSLADILKDRGIM----KLVKR 132

  Fly   456 TDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMAR-RYDHSSDSI 519
            |..:...:.:.:|:.....:.:.........:...|:.||.|...|....|.:|: .::.:...:
 Worm   133 TPKTLNDVDQWSIMMAYSRISYFLDFNFIRDLDSSDKNTLFKYNISRAGCLALAKCAFNENKPKL 197

  Fly   520 FFANN-RSYTRDSYKMAGMADNIEDLL--HFCRQMFSMKVDNVEYALLTAIVI--------FSDR 573
            .|.|: .::..:.|.:.|.:..:.:.:  ....:...:|:.:.||.||..::.        |||:
 Worm   198 TFPNDVDAFPSEMYNLCGSSTAVLNQVSGQVIAKFVELKIKDEEYLLLILVMFCNPSISNDFSDK 262

  Fly   574 PGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSL---VFYAKLLSILTEL-RTLGNQN 628
            ..|..:...:|..|         .|.|:|..:.|.   ..:.:|||:...: :::.|.|
 Worm   263 TKLALSSHQQAFCS---------ALFRYCQINYSKSAPTRFTELLSLFGIVNKSVDNMN 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	27/86 (31%)
		NR_LBD_EcR	420..652	CDD:132736	42/228 (18%)
nhr-197	NP_506901.1	ZnF_C4	2..69	CDD:197701	27/92 (29%)
		HOLI	152..306	CDD:214658	29/162 (18%)