Protein Alignment EcR and nhr-174

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_493149.2
• Gene: nhr-174 / 184021
• WormBaseID: WBGene00008474
• Length: 319
• Species: Caenorhabditis elegans
• Alignment Length: 363
• Identity: 73/363 - (20%)
• Similarity: 126/363 - (34%)
• Gaps: 98/363 - (26%)

  Fly   261 EELCLVCGDRAS-GYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKC 324
            :.:|.||...:: ..|:..|.|..|..||||:|:.:..|.|:....|:   ..|:.|:.||...|
 Worm     7 DPVCPVCEFPSNVELHFGGLVCGACAAFFRRTVSLNIRYLCEKKNQCK---GKRKNCRACRFDYC 68

  Fly   325 LAV-GMRPECVVPENQCA------MKRREKKAQKEKDK----MTTSPSSQHGGNGSLASGGGQDF 378
            :.: ||:...|.......      :.||:....:|..:    .|.|..:||....|::.
 Worm    69 VKIAGMKRNLVRQRKNSTNTPMYILNRRKDSGNEEVVRGFVTSTQSKWAQHSRKSSMSP------ 127

  Fly   379 VKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLR 443
             .||                       |:.....|..:::.:|...|                :.
 Worm   128 -NKE-----------------------AEKDVSKILKISHGRLLKYY----------------IY 152

  Fly   444 RIMSQPDENESQTDV-SFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLR 507
            :|......|.:..:: |.....|||.:..:|..|..|..|....:..||.:|:.|......:.:.
 Worm   153 QITQGKWVNMNTLNIKSVEEFLEITSIHNKLAAEICKTCPGVDLLDNEDILTIRKYFQFSNVWIE 217

  Fly   508 MARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIED--LLHFCRQMFS--------MKVDNVEYA 562
            .|..|..|:|               |...:.|:..|  ||.|..|:.|        :|.:.:|:|
 Worm   218 SAWNYLMSAD---------------KHVQIDDSELDLTLLKFINQVKSTLLVSLSQLKFNTIEFA 267

  Fly   563 LLTAIVIFS-DRPGLEKAQ----------LVEAIQSYY 589
            ...:|.|:. ...|..:|.          :.:|:..||
 Worm   268 AFKSICIWKLVYHGTSRAMKIIAQEHYEGVAKALNDYY 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	25/97 (26%)
		NR_LBD_EcR	420..652	CDD:132736	38/192 (20%)
nhr-174	NP_493149.2	ZnF_C4	10..77	CDD:197701	22/69 (32%)
		HOLI	177..314	CDD:214658	31/144 (22%)