Protein Alignment EcR and nhr-165

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_493119.2
• Gene: nhr-165 / 183558
• WormBaseID: WBGene00008158
• Length: 362
• Species: Caenorhabditis elegans
• Alignment Length: 401
• Identity: 83/401 - (20%)
• Similarity: 159/401 - (39%)
• Gaps: 72/401 - (17%)

  Fly   264 CLVCGDRASG-YHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCL-A 326
            ||:||...:. :|:..|:|..|..||||:|:.:..|.||....|......|..|:.||.:.|: .
 Worm    11 CLICGSICTAKFHFGGLSCNACASFFRRTVSLNIRYLCKNSNNCITSPGQRTFCKACRYESCVDK 75

  Fly   327 VGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEP 391
            .||:.:.|       .:||...|..:....:||.||    |..:..|    |:......|:|
 Worm    76 AGMKRDFV-------QQRRSTNATPKYILNSTSGSS----NREVVRG----FITDSNSHLVT--- 122

  Fly   392 PQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQ--PDENES 454
                             |..::.::..|:.....|.  |.|..|......||..:.|  |::.|.
 Worm   123 -----------------QTDHLRNIDNNEHCKDMKK--YSDLLEISHMNLLRFYVKQVEPEKKEL 168

  Fly   455 QTDVSFRHITEITILTVQ---LIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSS 516
            :..:..:.|.::.|....   ..:|.....|...|:.|||...|.|:.......|....:|..::
 Worm   169 KNILQIKSINDLMITCAYDNGSAMESCVHCPGTGKLSQEDVRLLQKSFQFAHTWLDSTWQYSIAT 233

  Fly   517 DSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQ-----MFSMKVDNVEYALLTAIVIFS-DRPG 575
            |.           |..:::|.::|:...:...:.     :.::|:|..|:|...:..::| ...|
 Worm   234 DI-----------DESEVSGESENLSQFISHIKSTLGACLANLKLDVYEFAAFKSFCVWSIGAQG 287

  Fly   576 LEKAQLVEAIQSY--YIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCF--SLK 636
            ..::..|.|.:.|  ....|::|.      .:.:.:..:::.:.:.|:....:.:.:|.:  ::|
 Worm   288 ATESMKVVAQEHYEAVASALKMYY------KTFTSMSDSEIATRIEEISFGRSSDVQMIYDETIK 346

  Fly   637 LKNR-KLPKFL 646
            |.|: .:||.|
 Worm   347 LYNKIGIPKSL 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	28/88 (32%)
		NR_LBD_EcR	420..652	CDD:132736	44/243 (18%)
nhr-165	NP_493119.2	ZnF_C4	10..81	CDD:197701	24/69 (35%)
		HOLI	186..329	CDD:214658	25/159 (16%)