Protein Alignment EcR and nhr-149

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_504874.2
• Gene: nhr-149 / 182174
• WormBaseID: WBGene00015397
• Length: 375
• Species: Caenorhabditis elegans
• Alignment Length: 437
• Identity: 112/437 - (25%)
• Similarity: 170/437 - (38%)
• Gaps: 114/437 - (26%)

  Fly   263 LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMR-----RKCQECRLK 322
            ||.:|...|.||||:.::|:|||.||||.........|.....| .|...|     .||:.||.:
 Worm     6 LCSICSRPAQGYHYDVISCKGCKTFFRRMWLSKIKEMCPLNNKC-FDFNRRINMSLSKCRACRFQ 69

  Fly   323 KCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVK-----KE 382
            :||.|||.|..:    ||                        .||....|...:||..     |.
 Worm    70 RCLNVGMNPAAI----QC------------------------DGNPKKDSSHFRDFDSIDEKIKN 106

  Fly   383 ILDLMTC---------EPPQHATIPL---LPDEILAKCQARNIPSLTYNQLAVIY-KLIWYQDGY 434
            |:|.:|.         :...:..:.|   |.|.|...|      ||:   ||.|| .:..:..|:
 Worm   107 IIDTLTYVELKLENYRKSAYNPVLSLSTGLDDLIEGSC------SLS---LAEIYGPMSGWPLGF 162

  Fly   435 EQ---PSEEDLRRIMSQ---PDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQI 493
            |:   || ..:|.:..:   |..|.       ::.|...:||.   :|:.|....|.::...|:.
 Worm   163 EEHQLPS-SSMRNVSCEEPCPVSNR-------KYWTHCNMLTT---IEYFKTFKFFHELSSRDKF 216

  Fly   494 TLLKACSSEVMMLRMAR-RYDHSSDSIFFANNRSYTRDS---YKMAGMADNIEDLLHFCRQMFSM 554
            .|.:........|.::. ...|:.||....:.....:..   |.:|.|  :||.|:. |
 Worm   217 VLARHTLLLCQNLHISHYTVSHNFDSCLQPDGSMQPKQDERHYPIAMM--SIEPLVR-C------ 272

  Fly   555 KVDNVEYALLTAIVIFSDR-PGL-EKAQLVEAIQSY-YIDTLRIYILNRHC------GDSMSLVF 610
            |:.:|||.||.||...:.. |.| :.||.:.|.:.| :.|     ||..||      |..    .
 Worm   273 KIQHVEYVLLKAICFCNPAVPELSQNAQRILAKERYCFAD-----ILINHCLRNYTDGPG----H 328

  Fly   611 YAKLLSILTELRTLGN--QNAEMCFSLKLKN---RKLPKFLEEIWDV 652
            :|:|:.|...|.|...  ::..:.:.:.|.|   |:|.|||.::.||
 Worm   329 FAELIGIFNLLETQQRMFKDLHIMYVVPLMNKFSRELIKFLSDVMDV 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	32/92 (35%)
		NR_LBD_EcR	420..652	CDD:132736	62/256 (24%)
nhr-149	NP_504874.2	ZnF_C4	6..78	CDD:197701	29/72 (40%)
		HOLI	190..342	CDD:214658	43/172 (25%)