Protein Alignment EcR and nhr-148

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_504871.1
• Gene: nhr-148 / 182172
• WormBaseID: WBGene00015396
• Length: 370
• Species: Caenorhabditis elegans
• Alignment Length: 457
• Identity: 93/457 - (20%)
• Similarity: 158/457 - (34%)
• Gaps: 153/457 - (33%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDM------YMRRKCQECRLK 322
            |.:|...|.||||:.::|:|||.||||....:....|.....| .|:      |:|  |:.||.:
 Worm    11 CSICRRNAKGYHYDVISCKGCKTFFRRMSLINFQGKCDLNNQC-FDLTKANEPYLR--CRACRYR 72

  Fly   323 KCLAVGMRPECV-VPE-NQC-----AMKRREKKA----QKEKDKMTTSPSSQH------------ 364
            |||.|||..:.: :|| ||.     .|.:....|    :::.:|...|..:.|
 Worm    73 KCLDVGMNQKAIQIPERNQTFGVIETMTKNTIDALVYLEEKLEKFRLSADNPHWQAVSDLELYLN 137

  Fly   365 -GGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILA--KCQARNIPSLTYNQLAVIYK 426
             |.|..||...|..| :..:.:  :.||...     ||..:.|  ..:..:.|:          |
 Worm   138 NGSNLGLADKFGPTF-ENSVHE--SFEPKNS-----LPSSLKAVQNNKLNHCPT----------K 184

  Fly   427 LIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQED 491
            .||                                     |:..:...||:.|....|..:...|
 Worm   185 KIW-------------------------------------TLCNLLTTVEYLKTFNYFKDLSALD 212

  Fly   492 QITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDS-----YKMAGMADNIEDLLHFCRQM 551
            ::.|.:    .|:::.......:.|.|..|....:...|:     |.:|.|         ....:
 Worm   213 KLILAR----HVILIGKNLHISNYSFSKKFTGCLNIETDAQRERHYPVAFM---------LMAPL 264

  Fly   552 FSMKVDNVEYALLTAIVIFSDR-PGL-EKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVF---- 610
            ...::..:||.||.||...:.. |.| :|||..               |.|..|..:|::|
 Worm   265 IRSQIQPIEYILLKAICCCNPAVPNLSQKAQST---------------LARERGQFVSILFDYCQ 314

  Fly   611 ---------YAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHLQIT 666
                     :|:|:.|               ||:..|.:::.|.:..::....:.|.|:..::..
 Worm   315 RSGKNGPGRFAELIGI---------------FSVMEKQQRMQKDMYMLYFAPHLTPDVKIQIKFL 364

  Fly   667 QE 668
            .:
 Worm   365 HD 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	35/103 (34%)
		NR_LBD_EcR	420..652	CDD:132736	41/251 (16%)
nhr-148	NP_504871.1	ZnF_C4	10..80	CDD:197701	28/71 (39%)
		HOLI	191..337	CDD:214658	35/188 (19%)