Protein Alignment EcR and nhr-12

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001122983.1
• Gene: nhr-12 / 179403
• WormBaseID: WBGene00003611
• Length: 456
• Species: Caenorhabditis elegans
• Alignment Length: 449
• Identity: 113/449 - (25%)
• Similarity: 181/449 - (40%)
• Gaps: 91/449 - (20%)

  Fly   258 RVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLK 322
            |.::..|.||.:...|.|:.|..|..|..||||||..|..|.|:.||.||:...:|..|:.||..
 Worm    41 RYEKPNCAVCNEVGDGLHFGAEACRACTAFFRRSVALSKKYECRAGRNCEVSSNIRCMCRSCRYD 105

  Fly   323 KCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLM 387
            ||:.|||.||||       ..|||....|...:..||.:.                :::.|.:..
 Worm   106 KCIEVGMNPECV-------QNRRENDTPKADLQFDTSKTE----------------IRRPIPNFN 147

  Fly   388 TCEPPQHATIP---------LLPDEILAKCQA---RNIPSLTYN-QLAVIYKLIWYQDGYEQPSE 439
            ..  ||.:.:|         :..|..::...|   .::|.|:.: .|..:..|...:..|::  .
 Worm   148 IV--PQASAVPSTSNFMDFSIFKDTPISNFSAFSPASLPGLSSSPSLETMPLLERMRINYDK--M 208

  Fly   440 EDLRRIMSQPD-ENESQTDV----SFRHITEITILTVQLIVEFAKG-LPAFTKIPQEDQITLLKA 498
            |:.|.::.:.: ||..|..|    :||..||:|...|.|:.::.:. ...|..:| .||.|:|..
 Worm   209 ENARNVIHRREGENIFQQKVPRAITFREATEVTTKEVSLVADWIEWCFDDFGLLP-VDQKTILFQ 272

  Fly   499 ------CSSE--VMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMK 555
                  |..|  .|.::..|      |.|....::.|.  .|      ||:|.....|..  ...
 Worm   273 NFFVFFCMLERAFMTVKSGR------DGIVVMASKDYI--DY------DNLEGFFKECNS--GTG 321

  Fly   556 VDNVEYALLTAIVIFSDRPG--LEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSIL 618
            ....|.|.|..::    ||.  |:|..|:..::...:|:...:.|   |   :.|.:...|....
 Worm   322 GTPAEIAKLCRLI----RPSFELQKRSLINLMRLENVDSYEFFAL---C---VMLFWDFGLEGQS 376

  Fly   619 TELRTLGNQ-----NAEMCFSLK-LKNRKLPKFLEEIWDVHAIPPSVQSHLQITQEENE 671
            .|...:|.:     ..||.|.|: :|..:.|  |..:..|.:|.||:|..::..||:.|
 Worm   377 DECNEVGRRVKHRVTREMTFYLRNVKKHEEP--LYRMASVVSILPSLQRAVRRFQEDIE 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	37/89 (42%)
		NR_LBD_EcR	420..652	CDD:132736	56/253 (22%)
nhr-12	NP_001122983.1	ZnF_C4	46..115	CDD:197701	30/68 (44%)
		Hormone_recep	225..425	CDD:459675	54/228 (24%)