DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14591 and Tmem164

DIOPT Version :9

Sequence 1:	NP_001188864.1	Gene:	CG14591 / 35531	FlyBaseID:	FBgn0033054	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_001186289.1	Gene:	Tmem164 / 209497	MGIID:	2148020	Length:	296	Species:	Mus musculus

Alignment Length:	272	Identity:	107/272 - (39%)
Similarity:	155/272 - (56%)	Gaps:	30/272 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DWAVGGISDEIPRTTGPECINYMTDRRRWLE-----TILLSALFIFIMH-----------RSWQR 52
            ||..||:........||:|..:::.::|.||     |:.|..:.:.:.|           ||.|
Mouse    11 DWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQKEDGRGGRSSQ- 74

  Fly    53 LAPIKLPPPHEIQKP----HSPTRLFLLIALSMIFGIEMGFKLSGQSMIFALNPCHVQSCLQIYL 113
                   |....|:|    .|.::..||:||.:|||:|:|||.:.:::|:.|||||:.:.:.|:|
Mouse    75 -------PQQVTQRPEEGKESLSKNLLLVALCLIFGVEVGFKFATKTVIYLLNPCHLVTMMHIFL 132

  Fly   114 LAAKPTKTTTALFRIQMSNLNGPFLAFLFPEVEGRTYPFEQATYWIQHALLYIIPIYII-RSGAY 177
            ||..|....|.:|::||..|||..||.|||.|..|..|||...|:||||:||::|:|:: :.|||
Mouse   133 LACPPCPGATVIFKLQMHMLNGALLALLFPVVNTRLLPFELEIYYIQHAMLYVVPVYLLWKGGAY 197

  Fly   178 TVEDLSEFHWSHIGTAFMLFYHFILLSPLSIFTGINLDHMLCAAMSDPFQGSNYRIFACCHQALL 242
            |.|.|..|.|:.:.|..|.||||..|..|.:.|.:||::|||.|:||||.|..|||:|..||.|:
Mouse   198 TPEPLCNFQWALLSTGLMFFYHFSFLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLM 262

  Fly   243 CPLLSKGTVVLF 254
            .....| .|:||
Mouse   263 TMTHGK-LVILF 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14591	NP_001188864.1	TMEM164	3..252	CDD:291474	104/268 (39%)
Tmem164	NP_001186289.1	TMEM164	10..272	CDD:291474	105/269 (39%)
Tmem164	NP_001186289.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..85		6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832132
Domainoid	1	1.000	196	1.000	Domainoid score	I3132
eggNOG	1	0.900	-	-		E1_28PNH
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12985
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3813
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58735
OrthoDB	1	1.010	-	-		D1509337at2759
OrthoFinder	1	1.000	-	-		FOG0006231
OrthoInspector	1	1.000	-	-		oto92877
orthoMCL	1	0.900	-	-		OOG6_105531
Panther	1	1.100	-	-	LDO	PTHR20948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2989
SonicParanoid	1	1.000	-	-		X4512
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800