Protein Alignment Not3 and Cnot3

DIOPT Version :10

• Sequence 1: NP_610176.1
• Gene: Not3 / 35501
• FlyBaseID: FBgn0033029
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001100941.2
• Gene: Cnot3 / 308311
• RGDID: 1304771
• Length: 751
• Species: Rattus norvegicus
• Alignment Length: 892
• Identity: 376/892 - (42%)
• Similarity: 496/892 - (55%)
• Gaps: 191/892 - (21%)

  Fly     1 MAATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQRLRD 65
            ||..||||||||||||||:||||.|||||:|:|||.|.|||     |||||||||||||||||||
  Rat     1 MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQK-----EKYEADLKKEIKKLQRLRD 60

  Fly    66 QIKSWIASAEIKDKSSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPAQRIKDDAR 130
            |||:|:||.|||||..|:|||:|||||||||||||||||||||||||||.|||:||||:.|::..
  Rat    61 QIKTWVASNEIKDKRQLIENRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVG 125

  Fly   131 NWLTSSISSLQIQIDQYESEIESL-LAGKKKRLDRDKQERMDDLRGKLDRHKFHITKLETLLRLL 194
            .|||::|.:|.:|:||:|||:||| :..:||:.|:|||:|::.|:..:::|::|:..|||:||:|
  Rat   126 QWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRML 190

  Fly   195 DNDGVEAEQVNKIKDDVEYYIDSSQEPDFEENEFIYDDIIGLDEVELSGTATTDSNNS------- 252
            |||.:..:.:.|||||||||:||||:||||||||:||| :.|:::..:..||:..::|
  Rat   191 DNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDD-LDLEDIPQALVATSPPSHSHMEDEIF 254

  Fly   253 NETSGSPSSVTSGG--SPSQSPVTVQQILNTSSQGAASSGSSAASAALFQQQLTAAQSNGNNVGY 315
            |::|.:|:|.||..  .||.:..|.:...:...:|.::....:.|.|          .||:...:
  Rat   255 NQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPA----------KNGSKPVH 309

  Fly   316 ASDTSAASSSATTSTDPAG---GTVAVNCVGGLADKRNKSSESNAL--KLKPQP-HQLIKPTPVR 374
            ::  ....|.|...|.|:|   .|.|::...|.......::..:||  |..|.| |....|.|.
  Rat   310 SN--QHPQSPAVPPTYPSGPPPATSALSSTPGNNGASTPAAPPSALGPKASPAPSHNSGTPAPY- 371

  Fly   375 ATAKLPLSSDTQVNKIVSSTPSKNQQQLPTAASIVATSAMQSQSSIGSCSSTGGTGASQS----- 434
            |.|..|.:         :|.||..|.:.|:|.....:......||..|.|.|||....|:
  Rat   372 AQAVAPPN---------ASGPSNAQPRPPSAQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSY 427

  Fly   435 -------------ASSGNNPGNNPAVQPNA----PTPG---QSGIAAAAASTNVVSATIVSSANV 479
                         :|||.:..::.|:.|.:    |.|.   :|..||.:.:.:|.|.   |..|.
  Rat   428 SSVVADSPAEVALSSSGGSSASSQALGPTSGPHNPAPSTLKESSTAAPSGAGSVASG---SGNNS 489

  Fly   480 QGQSVIQP-------TPTIAFAAVAKHNTSLLENGPVLQQQLAVTPTVAAIVGAGTQAQQKHVPP 537
            .|.|::.|       :||.:|:......|.|  |||   .|.:.||.:            |...|
  Rat   490 GGPSLLVPLPVNPPSSPTPSFSEAKAAGTLL--NGP---PQFSTTPEI------------KAPEP 537

  Fly   538 LSNLQTNSPHIQNGLPVSDSTNDNSCNVVDTISLKTMAQDAINRSAI-DPNSLNQQQTSSIDLRQ 601
            ||                              |||:||:.|...|.| ||       ..::.|
  Rat   538 LS------------------------------SLKSMAERAAISSGIEDP-------VPTLHL-- 563

  Fly   602 PQSQKSLLQHFNSETNTNQQQLTSQQQQQLQNNSLAATTGSNNGTSTGSGLMNVANATGQPISGN 666
                            |::..:.|                |.:...|.|          ||
  Rat   564 ----------------TDRDIILS----------------STSAPPTSS----------QP---- 582

  Fly   667 AKTHACQPQQMATTEAHIPTLLGVTPLGPTPLQKEHQMQFQMMEAAYYHLPQPMDTEKLQTYFHR 731
                   |.|:  :|.:||..|||.||||..|.||...|..|.|||::|:|.|.|:|:::.|..|
  Rat   583 -------PLQL--SEVNIPLSLGVCPLGPVSLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPR 638

  Fly   732 APVLTPSHYPQAQMPIYDTVEFYQRLSTETLFFVFYYMEGSKAQYLAAKALKKQSWRFHTKYMMW 796
            .|..||.::.|...|..||||||||||||||||:|||:||:||||||||||||||||||||||||
  Rat   639 NPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMW 703

  Fly   797 FQRHEEPKIINDDYEQGTYIYFDYEKWSQRKKEGFTFEYKYLEDKEL 843
            ||||||||.|.|::|||||||||||||.|||||||||||:||||::|
  Rat   704 FQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDL 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Not3	NP_610176.1	Not3	3..233	CDD:461155	156/230 (68%)
		PRK07764	<334..497	CDD:236090	49/200 (25%)
		NOT2_3_5	711..836	CDD:461199	92/124 (74%)
Cnot3	NP_001100941.2	Not3	3..229	CDD:461155	157/231 (68%)
		PHA03247	<288..657	CDD:223021	120/504 (24%)
		NOT2_3_5	618..743	CDD:461199	92/124 (74%)