DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atf6 and Atf6

DIOPT Version :9

Sequence 1:	NP_995745.1	Gene:	Atf6 / 35480	FlyBaseID:	FBgn0033010	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001074773.1	Gene:	Atf6 / 226641	MGIID:	1926157	Length:	656	Species:	Mus musculus

Alignment Length:	775	Identity:	180/775 - (23%)
Similarity:	292/775 - (37%)	Gaps:	220/775 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EYNLYNDLSLLGEVTENNYDNNIVHDILNSSAFYNDTSLDLSELIPDLQKEAFGLHFSS------ 63
            |..|:.:|....:..:.::|  ..|:...::..:.:..|||.....||...  |.||.|
Mouse    18 ESTLFAELGYFTDTDDVHFD--AAHEAYENNFDHLNFDLDLMPWESDLWSP--GSHFCSDMKAEP 78

  Fly    64 ---NPITSEFSLSSPISGLKQIPSACSGEFKRNVNDNNFQLDLTNSRNDLPEPNSSPTRSLNRSN 125
               :|.:|..|:|||.|     ..:||.  .::|.:   :|||.:|       :.||......|
Mouse    79 QPLSPASSSCSISSPRS-----TDSCSS--TQHVPE---ELDLLSS-------SQSPLSLYGDS- 125

  Fly   126 VNGCSNEEAVYPL----------------LVDSDKFD----------PFFEPAKVRSPNKEFNST 164
               |::..:|.||                |....|..          |...||   :|..:.|::
Mouse   126 ---CNSPSSVEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPA---APKTQTNAS 184

  Fly   165 ISNLSDIKNELPE----TSQDLGFNSYNTSRNNSTLTKSWPINTELNLDNQVPKTVLPLSRTI-- 223
            :...:.|...||.    ..|....:.........|:..|.|...:|    |.| .||..::.:
Mouse   185 VPAKAIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPTVVQL----QSP-AVLSSAQPVLA 244

  Fly   224 ------YLPSHDYKGL-LPTVK--CNGDRTLKKNVNVRSKISNIVIKKKNATFIQSLKESTPSHT 279
                  .||:|....| .|.|.  .||..::.|.|                     |:.:|.|..
Mouse   245 VTGGAAQLPNHVVNVLPAPVVSSPVNGKLSVTKPV---------------------LQSATRSMG 288

  Fly   280 MDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRINKLEKECDSLKAENITLRDQIFLLATSC 344
            .|..:.::.||||||||||..||||:|||::.||.|:.....|.:.||.||.:|:.|:..:.
Mouse   289 SDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDEVV--- 350

  Fly   345 QRESGNANGLLHNYSGSERSENKNGRFTSKAKHCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQ 409
                               |||:..:..|..            ::.|.::..:||:: ||.|..
Mouse   351 -------------------SENQRLKVPSPK------------RRAVCVMIVLAFIM-LNYGPM- 382

  Fly   410 KYLNIPNNLEGKS-EIEPVGKQLSMSN-RRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSG 472
                  :.||.:| .::|   .:|.:| ||.|...|.:|.|:.::     ...||:...|
Mouse   383 ------SMLEQESRRVKP---SVSPANQRRHLLEFSAKEVKDTSD-----GDNQKDSYSY----- 428

  Fly   473 IRNHKINSFENITKNVSHTYSYNEPPPLTYL-----------STRNCINRCRSHNGSSNQSKYFM 526
              :|.:::.:.:.........|..|||...|           ..|..::|   |.....:|:...
Mouse   429 --DHSVSNDKALMVLSEEPLLYMPPPPCQPLINTTESLRLNHELRGWVHR---HEVERTKSRRMT 488

  Fly   527 LAQNLHKWISGTLNVSNFSKEKEDSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTSVLPEKQ 591
            .:|...:.:.|.|        ::.||                    .:.|.:...:.||:.....
Mouse   489 NSQQKARILQGAL--------EQGSN--------------------SQLMAVQYTETTSISRNSG 525

  Fly   592 QKLN----NTKSFENMREQINVISKIERRDDTFYVFSFNMDHALLPALSYNSSYRPKLSLVLPLE 652
            .:|.    :..|::..      ...|.||.|||||.||..||.||||.::|.:.|||:|:|||..
Mouse   526 SELQVYYASPGSYQGF------FDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAI 584

  Fly   653 NPG---INGK--MKMIQVDCEVFNTKDFEVSHHLFPAKLRQNVIPRKPNKLNIKKSSTET 707
            |..   |||:  ..|:|:||:|.:|:...:.....|..||.:...:.........::|||
Mouse   585 NINDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTTTET 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	27/50 (54%)
Atf6	NP_995745.1	coiled coil	287..338	CDD:269848	27/50 (54%)
Atf6	NP_001074773.1	Transcription activation. /evidence=ECO:0000305	1..137		30/127 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..169		27/128 (21%)
		Ribophorin_II	<223..>298	CDD:368624	18/85 (21%)
		Basic motif	295..326		17/30 (57%)
		bZIP_ATF6	296..347	CDD:269848	25/50 (50%)
		coiled coil	296..347	CDD:269848	25/50 (50%)
		Leucine-zipper	335..342		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..429		6/37 (16%)
		Interaction with THBS4. /evidence=ECO:0000269\|PubMed:22682248	455..575		21/130 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..656		13/23 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834561
Domainoid	1	1.000	55	1.000	Domainoid score	I11074
eggNOG	1	0.900	-	-		E1_KOG4343
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I5031
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003511
OrthoInspector	1	1.000	-	-		otm43864
orthoMCL	1	0.900	-	-		OOG6_106428
Panther	1	1.100	-	-	O	PTHR46164
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3813
SonicParanoid	1	1.000	-	-		X2883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780