Protein Alignment Atf6 and Atf6

DIOPT Version :10

• Sequence 1: NP_995745.1
• Gene: Atf6 / 35480
• FlyBaseID: FBgn0033010
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_001074773.1
• Gene: Atf6 / 226641
• MGIID: 1926157
• Length: 656
• Species: Mus musculus
• Alignment Length: 775
• Identity: 180/775 - (23%)
• Similarity: 292/775 - (37%)
• Gaps: 220/775 - (28%)

  Fly     5 EYNLYNDLSLLGEVTENNYDNNIVHDILNSSAFYNDTSLDLSELIPDLQKEAFGLHFSS------ 63
            |..|:.:|....:..:.::|  ..|:...::..:.:..|||.....||...  |.||.|
Mouse    18 ESTLFAELGYFTDTDDVHFD--AAHEAYENNFDHLNFDLDLMPWESDLWSP--GSHFCSDMKAEP 78

  Fly    64 ---NPITSEFSLSSPISGLKQIPSACSGEFKRNVNDNNFQLDLTNSRNDLPEPNSSPTRSLNRSN 125
               :|.:|..|:|||.|     ..:||.  .::|.:   :|||.:|       :.||......|
Mouse    79 QPLSPASSSCSISSPRS-----TDSCSS--TQHVPE---ELDLLSS-------SQSPLSLYGDS- 125

  Fly   126 VNGCSNEEAVYPL----------------LVDSDKFD----------PFFEPAKVRSPNKEFNST 164
               |::..:|.||                |....|..          |...||   :|..:.|::
Mouse   126 ---CNSPSSVEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPA---APKTQTNAS 184

  Fly   165 ISNLSDIKNELPE----TSQDLGFNSYNTSRNNSTLTKSWPINTELNLDNQVPKTVLPLSRTI-- 223
            :...:.|...||.    ..|....:.........|:..|.|...:|    |.| .||..::.:
Mouse   185 VPAKAIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPTVVQL----QSP-AVLSSAQPVLA 244

  Fly   224 ------YLPSHDYKGL-LPTVK--CNGDRTLKKNVNVRSKISNIVIKKKNATFIQSLKESTPSHT 279
                  .||:|....| .|.|.  .||..::.|.|                     |:.:|.|..
Mouse   245 VTGGAAQLPNHVVNVLPAPVVSSPVNGKLSVTKPV---------------------LQSATRSMG 288

  Fly   280 MDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRINKLEKECDSLKAENITLRDQIFLLATSC 344
            .|..:.::.||||||||||..||||:|||::.||.|:.....|.:.||.||.:|:.|:..:.
Mouse   289 SDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDEVV--- 350

  Fly   345 QRESGNANGLLHNYSGSERSENKNGRFTSKAKHCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQ 409
                               |||:..:..|..            ::.|.::..:||:: ||.|..
Mouse   351 -------------------SENQRLKVPSPK------------RRAVCVMIVLAFIM-LNYGPM- 382

  Fly   410 KYLNIPNNLEGKS-EIEPVGKQLSMSN-RRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSG 472
                  :.||.:| .::|   .:|.:| ||.|...|.:|.|:.::     ...||:...|
Mouse   383 ------SMLEQESRRVKP---SVSPANQRRHLLEFSAKEVKDTSD-----GDNQKDSYSY----- 428

  Fly   473 IRNHKINSFENITKNVSHTYSYNEPPPLTYL-----------STRNCINRCRSHNGSSNQSKYFM 526
              :|.:::.:.:.........|..|||...|           ..|..::|   |.....:|:...
Mouse   429 --DHSVSNDKALMVLSEEPLLYMPPPPCQPLINTTESLRLNHELRGWVHR---HEVERTKSRRMT 488

  Fly   527 LAQNLHKWISGTLNVSNFSKEKEDSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTSVLPEKQ 591
            .:|...:.:.|.|        ::.||                    .:.|.:...:.||:.....
Mouse   489 NSQQKARILQGAL--------EQGSN--------------------SQLMAVQYTETTSISRNSG 525

  Fly   592 QKLN----NTKSFENMREQINVISKIERRDDTFYVFSFNMDHALLPALSYNSSYRPKLSLVLPLE 652
            .:|.    :..|::..      ...|.||.|||||.||..||.||||.::|.:.|||:|:|||..
Mouse   526 SELQVYYASPGSYQGF------FDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAI 584

  Fly   653 NPG---INGK--MKMIQVDCEVFNTKDFEVSHHLFPAKLRQNVIPRKPNKLNIKKSSTET 707
            |..   |||:  ..|:|:||:|.:|:...:.....|..||.:...:.........::|||
Mouse   585 NINDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTTTET 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	27/50 (54%)
		coiled coil	287..338	CDD:269848	27/50 (54%)
Atf6	NP_001074773.1	Transcription activation. /evidence=ECO:0000305	1..137		30/127 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..169		27/128 (21%)
		Basic motif	295..326		17/30 (57%)
		bZIP_ATF6	296..347	CDD:269848	25/50 (50%)
		coiled coil	296..347	CDD:269848	25/50 (50%)
		Leucine-zipper	335..342		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..429		6/37 (16%)
		Interaction with THBS4. /evidence=ECO:0000269|PubMed:22682248	455..575		21/130 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..656		13/23 (57%)