Protein Alignment: Atf6 and Atf6

• Sequence 1: NP_995745.1
• Gene: Atf6
• FlyBaseID: FBgn0033010
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_001074773.1
• Gene: Atf6
• MGIID: 1926157
• Length: 656
• Species: Mus musculus
• Alignment Length: 775
• Identity: 180/776 (23%)
• Similarity: 292/776 (38%)
• Gaps: 220/776 (28%)

  Fly     5 EYNLYNDLSLLGEVTENNYDNNIVHDILNSSAFYNDTSLDLSELIPDLQKEAFGLHFSS------ 63
            |..|:.:|....:..:.::|  ..|:...::..:.:..|||.....||...  |.||.|
Mouse    18 ESTLFAELGYFTDTDDVHFD--AAHEAYENNFDHLNFDLDLMPWESDLWSP--GSHFCSDMKAEP 78

  Fly    64 ---NPITSEFSLSSPISGLKQIPSACSGEFKRNVNDNNFQLDLTNSRNDLPEPNSSPTRSLNRSN 125
               :|.:|..|:|||.|     ..:||.  .::|.:   :|||.:|       :.||......|
Mouse    79 QPLSPASSSCSISSPRS-----TDSCSS--TQHVPE---ELDLLSS-------SQSPLSLYGDS- 125

  Fly   126 VNGCSNEEAVYPL----------------LVDSDKFD----------PFFEPAKVRSPNKEFNST 164
               |::..:|.||                |....|..          |...||   :|..:.|::
Mouse   126 ---CNSPSSVEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPA---APKTQTNAS 184

  Fly   165 ISNLSDIKNELPE----TSQDLGFNSYNTSRNNSTLTKSWPINTELNLDNQVPKTVLPLSRTI-- 223
            :...:.|...||.    ..|....:.........|:..|.|...:|    |.| .||..::.:
Mouse   185 VPAKAIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPTVVQL----QSP-AVLSSAQPVLA 244

  Fly   224 ------YLPSHDYKGL-LPTVK--CNGDRTLKKNVNVRSKISNIVIKKKNATFIQSLKESTPSHT 279
                  .||:|....| .|.|.  .||..::.|.|                     |:.:|.|..
Mouse   245 VTGGAAQLPNHVVNVLPAPVVSSPVNGKLSVTKPV---------------------LQSATRSMG 288

  Fly   280 MDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRINKLEKECDSLKAENITLRDQIFLLATSC 344
            .|..:.::.||||||||||..||||:|||::.||.|:.....|.:.||.||.:|:.|:..:.
Mouse   289 SDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDEVV--- 350

  Fly   345 QRESGNANGLLHNYSGSERSENKNGRFTSKAKHCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQ 409
                               |||:..:..|..            ::.|.::..:||:: ||.|..
Mouse   351 -------------------SENQRLKVPSPK------------RRAVCVMIVLAFIM-LNYGPM- 382

  Fly   410 KYLNIPNNLEGKS-EIEPVGKQLSMSN-RRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSG 472
                  :.||.:| .::|   .:|.:| ||.|...|.:|.|:.::     ...||:...|
Mouse   383 ------SMLEQESRRVKP---SVSPANQRRHLLEFSAKEVKDTSD-----GDNQKDSYSY----- 428

  Fly   473 IRNHKINSFENITKNVSHTYSYNEPPPLTYL-----------STRNCINRCRSHNGSSNQSKYFM 526
              :|.:::.:.:.........|..|||...|           ..|..::|   |.....:|:...
Mouse   429 --DHSVSNDKALMVLSEEPLLYMPPPPCQPLINTTESLRLNHELRGWVHR---HEVERTKSRRMT 488

  Fly   527 LAQNLHKWISGTLNVSNFSKEKEDSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTSVLPEKQ 591
            .:|...:.:.|.|        ::.||                    .:.|.:...:.||:.....
Mouse   489 NSQQKARILQGAL--------EQGSN--------------------SQLMAVQYTETTSISRNSG 525

  Fly   592 QKLN----NTKSFENMREQINVISKIERRDDTFYVFSFNMDHALLPALSYNSSYRPKLSLVLPLE 652
            .:|.    :..|::..      ...|.||.|||||.||..||.||||.::|.:.|||:|:|||..
Mouse   526 SELQVYYASPGSYQGF------FDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAI 584

  Fly   653 NPG---INGK--MKMIQVDCEVFNTKDFEVSHHLFPAKLRQNVIPRKPNKLNIKKSSTET 707
            |..   |||:  ..|:|:||:|.:|:...:.....|..||.:...:.........::|||
Mouse   585 NINDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTTTET 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	27/51 (53%)
		coiled coil	287..338	CDD:269848	27/51 (53%)
Atf6	NP_001074773.1	Transcription activation. {ECO:0000250}	1..137		30/128 (23%)
		Ribophorin_II	<223..>298	CDD:283474	18/86 (21%)
		Basic motif	295..326		18/31 (58%)
		bZIP_ATF6	296..347	CDD:269848	26/51 (51%)
		coiled coil	296..347	CDD:269848	26/51 (51%)
		Leucine-zipper	335..342		3/7 (43%)
		Interaction with THBS4. {ECO:0000269|PubMed:22682248}	455..575		21/131 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C112481025
eggNOG	1	0.900				E1_KOG4343
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I4996
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0001855
OrthoInspector	1	1.000				T616220
orthoMCL	1	0.900				OOG5_134659
Panther	1	1.100			O	PTHR46164
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R3813
TreeFam	1	0.960
	11	10.780