DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atf6 and Atf6

DIOPT Version :9

Sequence 1:NP_995745.1 Gene:Atf6 / 35480 FlyBaseID:FBgn0033010 Length:741 Species:Drosophila melanogaster
Sequence 2:NP_001074773.1 Gene:Atf6 / 226641 MGIID:1926157 Length:656 Species:Mus musculus


Alignment Length:775 Identity:180/775 - (23%)
Similarity:292/775 - (37%) Gaps:220/775 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EYNLYNDLSLLGEVTENNYDNNIVHDILNSSAFYNDTSLDLSELIPDLQKEAFGLHFSS------ 63
            |..|:.:|....:..:.::|  ..|:...::..:.:..|||.....||...  |.||.|      
Mouse    18 ESTLFAELGYFTDTDDVHFD--AAHEAYENNFDHLNFDLDLMPWESDLWSP--GSHFCSDMKAEP 78

  Fly    64 ---NPITSEFSLSSPISGLKQIPSACSGEFKRNVNDNNFQLDLTNSRNDLPEPNSSPTRSLNRSN 125
               :|.:|..|:|||.|     ..:||.  .::|.:   :|||.:|       :.||......| 
Mouse    79 QPLSPASSSCSISSPRS-----TDSCSS--TQHVPE---ELDLLSS-------SQSPLSLYGDS- 125

  Fly   126 VNGCSNEEAVYPL----------------LVDSDKFD----------PFFEPAKVRSPNKEFNST 164
               |::..:|.||                |....|..          |...||   :|..:.|::
Mouse   126 ---CNSPSSVEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPA---APKTQTNAS 184

  Fly   165 ISNLSDIKNELPE----TSQDLGFNSYNTSRNNSTLTKSWPINTELNLDNQVPKTVLPLSRTI-- 223
            :...:.|...||.    ..|....:.........|:..|.|...:|    |.| .||..::.:  
Mouse   185 VPAKAIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPTVVQL----QSP-AVLSSAQPVLA 244

  Fly   224 ------YLPSHDYKGL-LPTVK--CNGDRTLKKNVNVRSKISNIVIKKKNATFIQSLKESTPSHT 279
                  .||:|....| .|.|.  .||..::.|.|                     |:.:|.|..
Mouse   245 VTGGAAQLPNHVVNVLPAPVVSSPVNGKLSVTKPV---------------------LQSATRSMG 288

  Fly   280 MDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRINKLEKECDSLKAENITLRDQIFLLATSC 344
            .|..:.::.||||||||||..||||:|||::.||.|:.....|.:.||.||.:|:.|:..:.   
Mouse   289 SDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDEVV--- 350

  Fly   345 QRESGNANGLLHNYSGSERSENKNGRFTSKAKHCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQ 409
                               |||:..:..|..            ::.|.::..:||:: ||.|.. 
Mouse   351 -------------------SENQRLKVPSPK------------RRAVCVMIVLAFIM-LNYGPM- 382

  Fly   410 KYLNIPNNLEGKS-EIEPVGKQLSMSN-RRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSG 472
                  :.||.:| .::|   .:|.:| ||.|...|.:|.|:.::     ...||:...|     
Mouse   383 ------SMLEQESRRVKP---SVSPANQRRHLLEFSAKEVKDTSD-----GDNQKDSYSY----- 428

  Fly   473 IRNHKINSFENITKNVSHTYSYNEPPPLTYL-----------STRNCINRCRSHNGSSNQSKYFM 526
              :|.:::.:.:.........|..|||...|           ..|..::|   |.....:|:...
Mouse   429 --DHSVSNDKALMVLSEEPLLYMPPPPCQPLINTTESLRLNHELRGWVHR---HEVERTKSRRMT 488

  Fly   527 LAQNLHKWISGTLNVSNFSKEKEDSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTSVLPEKQ 591
            .:|...:.:.|.|        ::.||                    .:.|.:...:.||:.....
Mouse   489 NSQQKARILQGAL--------EQGSN--------------------SQLMAVQYTETTSISRNSG 525

  Fly   592 QKLN----NTKSFENMREQINVISKIERRDDTFYVFSFNMDHALLPALSYNSSYRPKLSLVLPLE 652
            .:|.    :..|::..      ...|.||.|||||.||..||.||||.::|.:.|||:|:|||..
Mouse   526 SELQVYYASPGSYQGF------FDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAI 584

  Fly   653 NPG---INGK--MKMIQVDCEVFNTKDFEVSHHLFPAKLRQNVIPRKPNKLNIKKSSTET 707
            |..   |||:  ..|:|:||:|.:|:...:.....|..||.:...:.........::|||
Mouse   585 NINDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTTTET 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atf6NP_995745.1 bZIP_ATF6 287..338 CDD:269848 27/50 (54%)
coiled coil 287..338 CDD:269848 27/50 (54%)
Atf6NP_001074773.1 Transcription activation. /evidence=ECO:0000305 1..137 30/127 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..169 27/128 (21%)
Ribophorin_II <223..>298 CDD:368624 18/85 (21%)
Basic motif 295..326 17/30 (57%)
bZIP_ATF6 296..347 CDD:269848 25/50 (50%)
coiled coil 296..347 CDD:269848 25/50 (50%)
Leucine-zipper 335..342 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..429 6/37 (16%)
Interaction with THBS4. /evidence=ECO:0000269|PubMed:22682248 455..575 21/130 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..656 13/23 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834561
Domainoid 1 1.000 55 1.000 Domainoid score I11074
eggNOG 1 0.900 - - E1_KOG4343
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 96 1.000 Inparanoid score I5031
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003511
OrthoInspector 1 1.000 - - otm43864
orthoMCL 1 0.900 - - OOG6_106428
Panther 1 1.100 - - O PTHR46164
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3813
SonicParanoid 1 1.000 - - X2883
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.780

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