Protein Alignment Ir40a and grik2

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001410875.1
• Gene: grik2 / 556013
• ZFINID: ZDB-GENE-080414-1
• Length: 908
• Species: Danio rerio
• Alignment Length: 774
• Identity: 137/774 - (17%)
• Similarity: 258/774 - (33%)
• Gaps: 220/774 - (28%)

  Fly     6 ALGLLPYLLGLLNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVY 70
            ||.:.||....:|.|....:..:.|.    ::.|:.......|.....|...|.||....:..:.
Zfish   263 ALDVEPYRYSGVNMTGFRILNTENSQ----VSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALM 323

  Fly    71 LDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQL-LNSLH-DRH----LG 129
            .|                                |...:::.:.:..|: ::||. :||    .|
Zfish   324 YD--------------------------------AVHVVAVAVQQSPQITVSSLQCNRHKPWRFG 356

  Fly   130 HRLSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDN 194
            :|....|  ..|.|...:..|.|.           |....|         :|..|.:::..:.
Zfish   357 NRFMTLI--KEAHWDGLTGRINFN-----------RTNGLR---------TDFDLDVISLKEE-- 397

  Fly   195 LGLQRIPLLPTA--LSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRV 257
             ||::|.....|  |::..|.||:|                          .|..||:..|.:.|
Zfish   398 -GLEKIGTWDPASGLNMTENQKGKT--------------------------ANVTDSLSNRSLVV 435

  Fly   258 TGGRDHRLLMLLSK----HMNFRFKYIEAPGRTQGSMRS--------------EDGK-----DSN 299
            :...:...:|....    :.|.||:     |.....:|.              |||:     :|:
Zfish   436 STILEEPYVMFKKSDKPLYGNDRFE-----GYCVDLLRELAAILGFGYELRLVEDGRYGAQDESS 495

  Fly   300 DSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRP 361
            ..:.|.:..|...:||..:..:.:::.|.|.|:||  |.||..|..:  ..|...|..: :.:.|
Zfish   496 GQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY--RKPNGTNPGVFSFLNP 558

  Fly   362 FKQDIWPHLILTIIFSGPIFYGIIAL-PYIW-RRRWANSDVEHLGELYIHMTYLKEITPRLLKLK 424
            ...|||.:::|..:....:.:.|... ||.| .....|.|.:.:...:
Zfish   559 LSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNF----------------- 606

  Fly   425 PRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTS 489
              |:|::           .||.:...::|....:......:.:..::|. .|.::...|:|.|.:
Zfish   607 --TLLNS-----------FWFGVGALMQQGSELMPKALSTRIVGGIWWF-FTLIIISSYTANLAA 657

  Fly   490 QFARPAREPPINTLQ------RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVI 548
            .......|.||::..      :::..::.||..:...|::..            ..|..|.:.:.
Zfish   658 FLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKI------------STYDKMWEFMS 710

  Fly   549 NDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGC 613
            :......:.|:|.||:.:..  .|.|.|....|:.| |.|...|..|:...:.::...|...:|.
Zfish   711 SRRHSVMVKSIEEGIERVLT--SDYAFLMESTTIEF-VTQRNCNLTQIGGLIDSKAYGVGTPMGS 772

  Fly   614 PFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISP 678
            |:...:...::||.|.|.|..|....:..           .|..:.:|.||            |.
Zfish   773 PYRDKITIAILQLQEEGKLHMMKEKWWRG-----------NGCPEEENKEA------------SA 814

  Fly   679 LNLRMLQGAFIALGVGSLAAGVILLLEIVF---------------IKLDQARLWMLCSR 722
            |.::.:.|.||.|..|.:.:..:.:.|.::               ..:|:.|:.:.|.|
Zfish   815 LGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKQNAQLEKRSFCSAMVDELRVSLKCQR 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	19/95 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	24/97 (25%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	30/146 (21%)
grik2	NP_001410875.1	PBP1_iGluR_Kainate	37..414	CDD:380605	36/211 (17%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	78/422 (18%)