Protein Alignment Ir40a and Grik2

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_062182.1
• Gene: Grik2 / 54257
• RGDID: 2733
• Length: 908
• Species: Rattus norvegicus
• Alignment Length: 758
• Identity: 142/758 - (18%)
• Similarity: 262/758 - (34%)
• Gaps: 215/758 - (28%)

  Fly     6 ALGLLPYLLGLLNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVY 70
            ||.:.||....:|.|....:..:.       ||:...:::.|:..|..|         .|..:..
  Rat   263 ALDVEPYRYSGVNMTGFRILNTEN-------TQVSSIIEKWSMERLQAP---------PKPDSGL 311

  Fly    71 LDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDE-PNQLLNSLH-DRHLGHRLS 133
            ||.|:.......|.:|          |:          :|:.:.: |...::||. :||...|
  Rat   312 LDGFMTTDAALMYDAV----------HV----------VSVAVQQFPQMTVSSLQCNRHKPWR-- 354

  Fly   134 LFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPC-SDSQLQLVNWYDGDNLGL 197
                 :|.|:            :.::..........||.:|:.... :|..|.:::..:.   ||
  Rat   355 -----FGTRF------------MSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEE---GL 399

  Fly   198 QRIPLLPTA--LSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTG- 259
            ::|.....|  |::..:.||:    |.                      |..||:..|.:.||.
  Rat   400 EKIGTWDPASGLNMTESQKGK----PA----------------------NITDSLSNRSLIVTTI 438

  Fly   260 ----------------GRDH------RLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGK-----D 297
                            |.|.      .||..||..:.|.::.          ...||||     |
  Rat   439 LEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI----------RLVEDGKYGAQDD 493

  Fly   298 SNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIM 359
            .|..:.|.:..|...:||..:..:.:::.|.|.|:||  |.||..|..:  ..|...|..: :.:
  Rat   494 VNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY--RKPNGTNPGVFSFL 556

  Fly   360 RPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIW-RRRWANSDVEHLGELYIHMTYLKEITPRLLK 422
            .|...|||.:::|..:....:.:.|... ||.| .....|.|.:.:...:
  Rat   557 NPLSPDIWMYVLLACLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNF--------------- 606

  Fly   423 LKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQL 487
                |:|::           .||.:...::|....:......:.:..::|. .|.::...|:|.|
  Rat   607 ----TLLNS-----------FWFGVGALMRQGSELMPKALSTRIVGGIWWF-FTLIIISSYTANL 655

  Fly   488 TSQFARPAREPPINTLQ------RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALM--- 543
            .:.......|.||::..      :::...:.||..:...|:|.        ...:.:::|.|
  Rat   656 AAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSK--------ISTYDKMWAFMSSR 712

  Fly   544 RQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVA 608
            ||.|:       :.|.|.||:.:..  .|.|.|....|:.| |.|...|..|:...:.::...|.
  Rat   713 RQSVL-------VKSNEEGIQRVLT--SDYAFLMESTTIEF-VTQRNCNLTQIGGLIDSKGYGVG 767

  Fly   609 VQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDS 673
            ..:|.|:...:...::||.|.|.|..|....:..           .|..:.::.||
  Rat   768 TPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRG-----------NGCPEEESKEA--------- 812

  Fly   674 TVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKLDQARL 716
               |.|.::.:.|.||.|..|.:.:..:.:.|.::.....|:|
  Rat   813 ---SALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQL 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	20/77 (26%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	25/97 (26%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	34/149 (23%)
Grik2	NP_062182.1	PBP1_iGluR_Kainate	37..414	CDD:380605	37/208 (18%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	86/430 (20%)