Protein Alignment Ir40a and GluRIB

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 653
• Identity: 123/653 - (18%)
• Similarity: 224/653 - (34%)
• Gaps: 163/653 - (24%)

  Fly   139 WGARWPPSSRVIRFREPLRVVVVTRPRK---KAFRIYYN---QARPCSDSQLQLVNWYDGDNLGL 197
            |...|....::.|:...:.:..:|...|   ...|:.|.   .....:.:.:::..|  .|:.||
  Fly   416 WVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEW--NDDAGL 478

  Fly   198 QRIPLLPTALSVYANF-KGRTFRVPVFHSPPWFWV--------TYCNNSFEEDEEFNSLDSIEKR 253
            |.:......|..:..| |.||:.|......|:..:        .:.||.||
  Fly   479 QPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFE-------------- 529

  Fly   254 KVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFL 318
                  |....|..||:|.:...::.........||.:|    .::..:.|.:|.|...:||..:
  Fly   530 ------GYCKDLADLLAKELGINYELRLVKDGNYGSEKS----SAHGGWDGMVGELVRKEADIAI 584

  Fly   319 GDVGLSWERRKAIEFS--FFTLADS-----------GAFATHAPRRLNEALAIMRPFKQDIWPHL 370
            ..:.::.||.:.|:||  |.:|..|           |.|            :.|.|..|:||
  Fly   585 AAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVF------------SFMNPLSQEIW--- 634

  Fly   371 ILTIIFSGPIFYGI-IAL-------PYIWRRRWANSDVEHLGELYIHMTYL-KEITPRLLKLKP- 425
             :::|||   :.|: |.|       |:.||............:.:.|...| .:..|.::...|
  Fly   635 -VSVIFS---YIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPL 695

  Fly   426 -----------RTVLSAHQMPHQL-------------------FQKCIWFTLRLFLKQSCNELHN 460
                       :|...|..:...|                   .....||:|..|::|.|:....
  Fly   696 PAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPR 760

  Fly   461 GYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSS 525
            ....: :....|...|.:|...|:|.|.:.........|||:.:.|.           ::.|...
  Fly   761 SVSGR-IAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLA-----------MQTEVQY 813

  Fly   526 LEMLENGT-ELFRQLYALMRQQV---------INDPQGFFIDSVEAGIKLIAEG-GEDKAVLGGR 579
            ..:|...| :.||      |.|:         :|..:..|:.:.:.|||.:... |:...::...
  Fly   814 GTLLHGSTWDFFR------RSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESP 872

  Fly   580 ETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQY 644
            :..:.|.:: ..:..::.:.|.|:...:|..:|......:|..::.|.|:|.|.|:....:   |
  Fly   873 KNEYVNARE-PCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWW---Y 933

  Fly   645 QEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFI 709
            ::.|.:                 |.....|..|.|:|..:.|.|..|..|.|.:..:.:||..|.
  Fly   934 EKAECS-----------------THKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFR 981

  Fly   710 KLD 712
            ..|
  Fly   982 SRD 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	17/72 (24%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	27/114 (24%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	28/151 (19%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	11/65 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	93/505 (18%)
		Lig_chan	630..966	CDD:459656	69/381 (18%)