Protein Alignment Ir40a and Grik

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 696
• Identity: 141/696 - (20%)
• Similarity: 260/696 - (37%)
• Gaps: 163/696 - (23%)

  Fly    75 LQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYW 139
            :|.:.::.|:|      |..||::...|..:   ::|:.|.. |||...: :|:..|........
  Fly   277 VQEVAKALYES------EEPFQNVSCPLTNS---MALVYDGV-QLLAETY-KHVNFRPVALSCND 330

  Fly   140 GARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLV-----------NWYDGD 193
            .:.|.....::.:.:.|.:..:|.|    .|..|...|  :|.:|:::           .|...|
  Fly   331 DSAWDKGYTLVNYMKSLTLNGLTGP----IRFDYEGLR--TDFKLEVIELAVSGMQKIGQWSGED 389

  Fly   194 NLGLQRIPLLPTALSVYANFK---GRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKV 255
              |.|.....| |.|:..:.:   .::|.|....|.|:..:...:...|.:::|... .||
  Fly   390 --GFQENRPAP-AHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGF-GIE---- 446

  Fly   256 RVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGI--------GLLQ-- 310
                     |:..|||.:.|.:.:     |.|     ||.|      .|||        |:|:
  Fly   447 ---------LIDELSKKLGFSYTW-----RLQ-----EDNK------YGGIDPKTGEWNGMLREI 486

  Fly   311 -SGQADFFLGDVGLSWERRKAIEFSF-FTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILT 373
             ..:||..:.|:.::.||...::|:. |.....|.......:...:..:.|.||..::|
  Fly   487 IDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVW------ 545

  Fly   374 IIFSGPIFYGIIALPYIWRR----RWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQM 434
             ::.|..:.|:....::..|    .|.|.           ...::|.|               ::
  Fly   546 -LWLGLAYMGVSISMFVLGRLSPAEWDNP-----------YPCIEEPT---------------EL 583

  Fly   435 PHQL-FQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREP 498
            .:|. |..|:||::...|:|........|..:.:...:|. .|.:|...|:|.|.:.....:...
  Fly   584 ENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWF-FTLILVSSYTANLAAFLTVESLVT 647

  Fly   499 PINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQ--QVINDPQGFFIDSVE- 560
            |||....|........|...:...:.:. ..|:....::::|..||.  |.:.:.....:|.||
  Fly   648 PINDADDLSKNKGGVNYGAKIGGATFNF-FKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVEN 711

  Fly   561 AGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQ 625
            :....:.|....:.:...|.||    .|.|:   .|.:|.|    .:|::...|:..:|:..:::
  Fly   712 SNYAFLMESTTIEYITERRCTL----TQVGA---LLDEKGY----GIAMRKNWPYRDTLSQAVLE 765

  Fly   626 LFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIA 690
            :.|.|:|.||.    .|.:||            .:...|.|..:. ||..:: |.:..|.|.|:.
  Fly   766 MQEQGLLTKMK----TKWWQE------------KRGGGACSDADE-DSGAVA-LEISNLGGVFLV 812

  Fly   691 LGVGSLAAGVILLLEIVF-IK--------------LDQARLWMLCS 721
            :||||.....:.|||:|. :|              ||:.|..:.||
  Fly   813 MGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCS 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	21/82 (26%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	19/105 (18%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	30/143 (21%)
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	27/136 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	87/449 (19%)