Protein Alignment Ir40a and clumsy

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Alignment Length: 625
• Identity: 117/625 - (18%)
• Similarity: 224/625 - (35%)
• Gaps: 145/625 - (23%)

  Fly   143 WPPSSRVIRFREPL-------RVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNW--------YDG 192
            ||...|:|.|.:..       |:......::..|.:.:.:..  ||..|.|..|        .:.
  Fly   338 WPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELN--SDGFLDLATWDPVNGLDVLND 400

  Fly   193 DNLGLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRV 257
            |....:|         |......:||.|......|:.       :..|.:|...|....:.:
  Fly   401 DEESEKR---------VGQKLSNKTFIVSSRLGAPFL-------TLREPQEGEILTGNSRYE--- 446

  Fly   258 TGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVG 322
              |....|:..::|.:||:|::..:|....|::..     ...::.|.:..|..|.||..:.|:.
  Fly   447 --GYSIDLINEIAKMLNFKFEFRMSPDGKYGALNK-----VTQTWDGIVRQLIDGNADLGICDLT 504

  Fly   323 LSWERRKAIEFS--FFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGII 385
            ::..||:|::|:  |.||..|..| :..|....:..:.:.||..|:|.::....:|...:.:.:.
  Fly   505 MTSSRRQAVDFTPPFMTLGISILF-SKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALA 568

  Fly   386 AL-PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRL 449
            .: |..|.......:.|.:..::..|                              ...|.::..
  Fly   569 RMAPDDWENPHPCKEPEEVENIWSIM------------------------------NTTWLSIGS 603

  Fly   450 FLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDG 514
            .:.|.|:.|......:.:|.::|..|..:| :.|:|.|.:......:...||:.:.|.|
  Fly   604 LMGQGCDILPKAASTRLVTGMWWFFALMML-NSYTANLAAFLTNSRQANSINSAEDLAA------ 661

  Fly   515 YRLYVEKESSSLEMLENGTEL--FR----QLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDK 573
                  :.......:..|:.:  ||    ..|..|...:.:.....|..:.:.|::.:.:|....
  Fly   662 ------QSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLY 720

  Fly   574 AVLGGRETLFFNVQ------QYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGIL 632
            |.|....||.:||:      |.|.   .|..|.|    .:|:....|:...::..:::|.|.|.|
  Fly   721 AFLMESTTLEYNVERKCDLVQIGG---WLDYKSY----GIAMPFNSPYRKQISAAVLKLGELGQL 778

  Fly   633 DKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLA 697
                 ||..:::.:    .::.|....|:.|        |......|.|..:.|.|:.||:|.|:
  Fly   779 -----AELKRKWWK----EMHGGGNCEKSDE--------DGGDTPELGLENVGGVFLVLGLGLLS 826

  Fly   698 AGVILLLEIVF----------IKLDQ---------ARLWM 718
            |.|:...|.::          |.|.:         ||:|:
  Fly   827 AMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWI 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	17/72 (24%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	22/96 (23%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	29/152 (19%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	12/60 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	82/445 (18%)