Protein Alignment Ir40a and GluRIIA

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 698
• Identity: 135/698 - (19%)
• Similarity: 253/698 - (36%)
• Gaps: 186/698 - (26%)

  Fly    67 RNVYLDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHR 131
            |::|.:||     ::|..||.....:            ||.     .:.....|..: |:.||::
  Fly   262 RDIYNEDF-----KANITSVRLKVVD------------ANP-----FERKKTRLTKV-DQILGNQ 303

  Fly   132 LSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPCSDS-----------QLQ 185
            ..|.|..:.|       |:.|....|.|:.      |.:.::...|.|..|           :::
  Fly   304 TMLPILIYDA-------VVLFASSARNVIA------AMQPFHPPNRHCGSSSPWMLGAFIVNEMK 355

  Fly   186 LVN------WYDGDNLGL----QRI--------PLLPTALSVYANFKG----------------- 215
            .::      .:..:|:.|    |||        |.:...:.|:....|
  Fly   356 TISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQ 420

  Fly   216 ------RTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMN 274
                  :.:.|...:..|:|.:.      |:.|.|...:..|        |....|:..||:.|.
  Fly   421 DFSEQRKVYTVVTHYEEPYFMMK------EDHENFRGREKYE--------GYAVDLISKLSELME 471

  Fly   275 FRFKYIEAPGRTQGSMRSEDGKDSNDS--FTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--F 335
            |.::::...|         :||.:.::  :.|.|..|....|...:.|:.::..||..::|:  |
  Fly   472 FDYEFMIVNG---------NGKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPF 527

  Fly   336 FTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDV 400
            ..|..|.......|...|: .|.:.||..::|.::|...:.....|..|..|.|   |.|
  Fly   528 MQLGISILHYKSPPEPKNQ-FAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSY---REW----- 583

  Fly   401 EHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQL-----FQKCIWFTLRLFLKQSCNELHN 460
                                  |.|...:   |.|.:|     .....|..:...::|.|:.|..
  Fly   584 ----------------------LPPNPAI---QDPDELENIWNVNNSTWLMVGSIMQQGCDILPR 623

  Fly   461 GYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRL-QAAMIHDGYRLYVEKESS 524
            |...:.||.::|..|..:|: .|:|.|.:.......:..|.:||.| :...:|.|   .:...|:
  Fly   624 GPHMRILTGMWWFFALMMLS-TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFG---SMRGGST 684

  Fly   525 SLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQY 589
            ||...|:....:::.:..|:.   .:|..|...:.|...::..|.| ..|.|....:|.:|:::
  Fly   685 SLFFSESNDTDYQRAWNQMKD---FNPSAFTSTNKEGVARVRKEKG-GYAFLMETTSLTYNIER- 744

  Fly   590 GSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYK 654
            ..:..|:.:::..::..:||.:|..:..:|:..::||.|.|.|.||.    .|.::....|
  Fly   745 NCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMK----NKWWKNHNVT---- 801

  Fly   655 GSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVIL 702
                   .::|...:..:.::|.      |.|.|:.| .|.:..||||
  Fly   802 -------CDSYHEVDGDELSIIE------LGGVFLVL-AGGVLIGVIL 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	16/74 (22%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	22/97 (23%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	32/141 (23%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	32/178 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	91/439 (21%)
		Lig_chan	555..828	CDD:459656	66/336 (20%)