Protein Alignment Ir40a and Grik3

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001106187.1
• Gene: Grik3 / 298521
• RGDID: 71027
• Length: 919
• Species: Rattus norvegicus
• Alignment Length: 782
• Identity: 148/782 - (18%)
• Similarity: 265/782 - (33%)
• Gaps: 238/782 - (30%)

  Fly     6 ALGLLPYLLGLLNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVY 70
            ||.|.||....:|.|....:..|...    ::.||.......|.........|.|||...:..:.
  Rat   266 ALDLEPYRYSGVNLTGFRILNVDNPH----VSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALL 326

  Fly    71 LDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLH-DRH----LGH 130
            .|    .:|   ..||.:.:.                        |...:|||. .||    .|.
  Rat   327 YD----AVH---IVSVCYQRA------------------------PQMTVNSLQCHRHKAWRFGG 360

  Fly   131 RLSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPC-SDSQLQLVNWYDGDN 194
            |...||  ..|:|          |.|           ..||.:|:.... :|..|.:::..:.
  Rat   361 RFMNFI--KEAQW----------EGL-----------TGRIVFNKTSGLRTDFDLDIISLKED-- 400

  Fly   195 LGLQRIPLLPTA--LSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRV 257
             ||:::.:...|  |::....|||        .|                  |..||:..|.:.|
  Rat   401 -GLEKVGVWSPADGLNITEVAKGR--------GP------------------NVTDSLTNRSLIV 438

  Fly   258 TG-----------------GRDH------RLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGK--- 296
            |.                 |.|.      .||..|:..:.|.::.          ...||||
  Rat   439 TTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEI----------RLVEDGKYGA 493

  Fly   297 -DSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-A 357
             |....:.|.:..|...:||..:..:.::..|.|||:||  |.||..|..:  ..|...|.:: :
  Rat   494 QDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILY--RKPNGTNPSVFS 556

  Fly   358 IMRPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLL 421
            .:.|...|||.:::|..:....:.:.|... ||    .|.::...:.|...:...:
  Rat   557 FLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPY----EWYDAHPCNPGSEVVENNF--------- 608

  Fly   422 KLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQ 486
                 |:|::           .||.:...::|....:......:.:..::|. .|.::...|:|.
  Rat   609 -----TLLNS-----------FWFGMGSLMQQGSELMPKALSTRIIGGIWWF-FTLIIISSYTAN 656

  Fly   487 LTSQFARPAREPPINTLQ------RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQ 545
            |.:.......|.||::..      :::...:.||..:...|:|.        ...|.:::|.|..
  Rat   657 LAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSK--------ISTFEKMWAFMSS 713

  Fly   546 QVINDPQGFFIDSVEAGIK--LIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVA 608
            :    |.. .:.:.|.||:  |.|    |.|:|....|:.: :.|...|..|:...:.::...:.
  Rat   714 K----PSA-LVKNNEEGIQRTLTA----DYALLMESTTIEY-ITQRNCNLTQIGGLIDSKGYGIG 768

  Fly   609 VQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGS--VQAKNSEAYSRTESY 671
            ..:|.|:...:...::||.|.   ||:          .:...:.::||  .:.:|.||
  Rat   769 TPMGSPYRDKITIAILQLQEE---DKL----------HIMKEKWWRGSGCPEEENKEA------- 813

  Fly   672 DSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKL----------------DQARLWMLC 720
                 |.|.::.:.|.||.|..|.:.:.::.:.|.:: ||                |:.|..:.|
  Rat   814 -----SALGIQKIGGIFIVLAAGLVLSVLVAVGEFIY-KLRKTAEREQRSFCSTVADEIRFSLTC 872

  Fly   721 SR 722
            .|
  Rat   873 QR 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	19/76 (25%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	25/97 (26%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	30/148 (20%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate	37..417	CDD:380605	42/211 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	80/440 (18%)