Protein Alignment Ir40a and Gria4

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_058959.2
• Gene: Gria4 / 29629
• RGDID: 61863
• Length: 902
• Species: Rattus norvegicus
• Alignment Length: 578
• Identity: 123/578 - (21%)
• Similarity: 216/578 - (37%)
• Gaps: 138/578 - (23%)

  Fly   162 TRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVYANFKGRTFRVPVFHSP 226
            |.|||..:                   |.|.|.|.|  |..:||..:..|..:.||..|......
  Rat   382 TGPRKVGY-------------------WNDMDKLVL--IQDMPTLGNDTAAIENRTVVVTTIMES 425

  Fly   227 PWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMR 291
            |  :|.|..|    .|.|...|..|        |....|...::||:..::|....|....|: |
  Rat   426 P--YVMYKKN----HEMFEGNDKYE--------GYCVDLASEIAKHIGIKYKIAIVPDGKYGA-R 475

  Fly   292 SEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNE 354
            ..|.|..|    |.:|.|..|:|:..:..:.::..|.:.|:||  |.:|..|  .....|::...
  Rat   476 DADTKIWN----GMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQKSKP 534

  Fly   355 AL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIAL--------PYIWRRRWANSDVEHLGELYIHM 410
            .: :.:.|...:||    :.|:|:   :.|:..:        ||.|          |..|
  Rat   535 GVFSFLDPLAYEIW----MCIVFA---YIGVSVVLFLVSRFSPYEW----------HTEE----- 577

  Fly   411 TYLKEITPRLLKLKPRTVLSAHQMPHQ--LFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWI 473
                   |...|..|     :.|.|::  :|.. :||:|..|::|.|:........:.:..|:|.
  Rat   578 -------PEDGKEGP-----SDQPPNEFGIFNS-LWFSLGAFMQQGCDISPRSLSGRIVGGVWWF 629

  Fly   474 AATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT--ELF 536
             .|.::...|:|.|.:.........||.:.:.|            .::...:...|::|:  |.|
  Rat   630 -FTLIIISSYTANLAAFLTVERMVSPIESAEDL------------AKQTEIAYGTLDSGSTKEFF 681

  Fly   537 R--------QLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNN 593
            |        :::..||..   :|..|...:.|...::....|:...:|......:.. |:...:.
  Rat   682 RRSKIAVYEKMWTYMRSA---EPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDT 742

  Fly   594 FQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQ 658
            .::...|.::...||...|......:|..:::|.|:|:|||:.    .|.:.:       ||...
  Rat   743 MKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLK----NKWWYD-------KGECG 796

  Fly   659 AKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQAR 715
            .|:|.:..:|        |.|:|..:.|.|..| ||.|. |.::.|:|..:....:|:
  Rat   797 PKDSGSKDKT--------SALSLSNVAGVFYIL-VGGLGLAMLVALIEFCYKSRAEAK 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	19/72 (26%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	22/104 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	27/150 (18%)
Gria4	NP_058959.2	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	9/38 (24%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	94/464 (20%)