Protein Alignment Ir40a and Gria3

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_116785.2
• Gene: Gria3 / 29628
• RGDID: 70958
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 117/587 - (19%)
• Similarity: 216/587 - (36%)
• Gaps: 135/587 - (22%)

  Fly   161 VTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVYANFKGRTFRV-PVFH 224
            |:..||..:...|.:..|.||.|:      ..|:                ::.:.||..| .:..
  Rat   384 VSGSRKAGYWNEYERFVPFSDQQI------SNDS----------------SSSENRTIVVTTILE 426

  Fly   225 SPPWFWVTYCNN--SFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQ 287
            ||   :|.|..|  ..|.:|.:.              |....|...::||:..::| :...|..:
  Rat   427 SP---YVMYKKNHEQLEGNERYE--------------GYCVDLAYEIAKHVRIKYK-LSIVGDGK 473

  Fly   288 GSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPR 350
            ...|..:.|..|    |.:|.|..|:||..:..:.::..|.:.|:||  |.:|..|  .....|:
  Rat   474 YGARDPETKIWN----GMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQ 532

  Fly   351 RLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIAL--------PYIWRRRWANSDVEHLGEL 406
            :....: :.:.|...:||    :.|:|:   :.|:..:        ||.|.....|.:
  Rat   533 KSKPGVFSFLDPLAYEIW----MCIVFA---YIGVSVVLFLVSRFSPYEWHLEDNNEE------- 583

  Fly   407 YIHMTYLKEITPRLLKLKPRTVLSAHQMPHQ--LFQKCIWFTLRLFLKQSCNELHNGYRAKFLTI 469
                              ||...|....|::  :|.. :||:|..|::|.|:........:.:..
  Rat   584 ------------------PRDPQSPPDPPNEFGIFNS-LWFSLGAFMQQGCDISPRSLSGRIVGG 629

  Fly   470 VYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT- 533
            |:|. .|.::...|:|.|.:.........||.:.:.|            .::...:...|::|:
  Rat   630 VWWF-FTLIIISSYTANLAAFLTVERMVSPIESAEDL------------AKQTEIAYGTLDSGST 681

  Fly   534 -ELFRQ----LYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNN 593
             |.||:    :|..|...:.:.....|..:...|:..:.:.....|.|.......:..|:...:.
  Rat   682 KEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDT 746

  Fly   594 FQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQ 658
            .::...|.::...||...|......:|..:::|.|.|||||:.    .|.:.:       ||...
  Rat   747 MKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLK----NKWWYD-------KGECG 800

  Fly   659 AKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQARLWMLCSR 722
            ||:|.:..:|        |.|:|..:.|.|..| ||.|. |.::.|:|..:....:::...|...
  Rat   801 AKDSGSKDKT--------SALSLSNVAGVFYIL-VGGLGLAMMVALIEFCYKSRAESKRMKLTKN 856

  Fly   723 LQ 724
            .|
  Rat   857 TQ 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	18/72 (25%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	23/104 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	27/146 (18%)
Gria3	NP_116785.2	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	5/18 (28%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	90/463 (19%)