Protein Alignment Ir40a and Gria2

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_058957.1
• Gene: Gria2 / 29627
• RGDID: 61862
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 790
• Identity: 159/790 - (20%)
• Similarity: 281/790 - (35%)
• Gaps: 227/790 - (28%)

  Fly    25 IGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLD-------DFLQRL---- 78
            |.||:.|      :..|.|.|              |...:|||.|.||       |.:.::
  Rat   183 INNDKKD------ETYRSLFQ--------------DLELKKERRVILDCERDKVNDIVDQVITIG 227

  Fly    79 -HRSNYKSVV----FSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFY 138
             |...|..::    |:..:|    ::....|||.....|:|..:.|            :|.||..
  Rat   228 KHVKGYHYIIANLGFTDGDL----LKIQFGGANVSGFQIVDYDDSL------------VSKFIER 276

  Fly   139 WGA----RWPPS-SRVIRFREPL---RVVVVTRPRKKAFRIYYNQ--------------ARPCSD 181
            |..    .:|.: :..|::...|   .|.|:|    :|||....|              |.|.
  Rat   277 WSTLEEKEYPGAHTATIKYTSALTYDAVQVMT----EAFRNLRKQRIEISRRGNAGDCLANPA-- 335

  Fly   182 SQLQLVNWYDGDNL--GLQRIPL--LPTALSVYANFKGRTFRVPVF----HSPP----WFWVTYC 234
                 |.|..|..:  .|:::.:  |...:....|.|...:.:.:.    :.|.    |..|...
  Rat   336 -----VPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395

  Fly   235 NNSFEEDEEFNSLDSIEKRKVRVTG---------GRDHRLL--------------MLLSKHMNFR 276
            ..:..|....|....:|.:.|.||.         .::|.:|              ..::||..|:
  Rat   396 VVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK 460

  Fly   277 FKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLA 339
            :| :...|..:...|..|.|..|    |.:|.|..|:||..:..:.::..|.:.|:||  |.:|.
  Rat   461 YK-LTIVGDGKYGARDADTKIWN----GMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLG 520

  Fly   340 DSGAFATHAPRRLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRR----RWANSD 399
            .|  .....|::....: :.:.|...:||    :.|:|:   :.|:..:.::..|    .|...:
  Rat   521 IS--IMIKKPQKSKPGVFSFLDPLAYEIW----MCIVFA---YIGVSVVLFLVSRFSPYEWHTEE 576

  Fly   400 VEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRA 464
            .|...|     |...|.|...                .:|.. :||:|..|::|.|:........
  Rat   577 FEDGRE-----TQSSESTNEF----------------GIFNS-LWFSLGAFMRQGCDISPRSLSG 619

  Fly   465 KFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEML 529
            :.:..|:|. .|.::...|:|.|.:.........||.:.:.|.            ::...:...|
  Rat   620 RIVGGVWWF-FTLIIISSYTANLAAFLTVERMVSPIESAEDLS------------KQTEIAYGTL 671

  Fly   530 ENGT--ELFR--------QLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFF 584
            ::|:  |.||        :::..||..   :|..|...:.|...::....|:...:|  ..|:..
  Rat   672 DSGSTKEFFRRSKIAVFDKMWTYMRSA---EPSVFVRTTAEGVARVRKSKGKYAYLL--ESTMNE 731

  Fly   585 NVQQ--------YGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYA 641
            .::|        .|.|   |..|.|...:.....:|.|    :|..:::|.|.|:|||:.    .
  Rat   732 YIEQRKPCDTMKVGGN---LDSKGYGIATPKGSSLGTP----VNLAVLKLSEQGVLDKLK----N 785

  Fly   642 KQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLA-AGVILLLE 705
            |.:.:       ||...||:|.:..:|        |.|:|..:.|.|..| ||.|. |.::.|:|
  Rat   786 KWWYD-------KGECGAKDSGSKEKT--------SALSLSNVAGVFYIL-VGGLGLAMLVALIE 834

  Fly   706 IVFIKLDQAR 715
            ..:....:|:
  Rat   835 FCYKSRAEAK 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	20/86 (23%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	21/96 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	31/158 (20%)
Gria2	NP_058957.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	51/261 (20%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	88/452 (19%)
		Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133	867..877