DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir40a and GRIN2D

DIOPT Version :10

Sequence 1:NP_610140.4 Gene:Ir40a / 35449 FlyBaseID:FBgn0259683 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_000827.2 Gene:GRIN2D / 2906 HGNCID:4588 Length:1336 Species:Homo sapiens


Alignment Length:521 Identity:93/521 - (17%)
Similarity:160/521 - (30%) Gaps:186/521 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 AIALTQIVRGLQQSSLAILA----LPSLALSDGVCQKERNVYLDDFLQRLHRSNYKSVVFSQTEL 93
            |..:..:.||.|    |:|.    ||.|...   |:.:...:..:.|.|.    :.::.:...:.
Human   321 AAGVAVVARGAQ----ALLRDYGFLPELGHD---CRAQNRTHRGESLHRY----FMNITWDNRDY 374

  Fly    94 FFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIRFREPL-- 156
            .|......:..:...|||..|...:::.|...:.|  ||         ::|..||..||.:|:  
Human   375 SFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTL--RL---------KYPLWSRYGRFLQPVDD 428

  Fly   157 -----------RVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVY 210
                       |..|:..|...........:.||. |||                          
Human   429 TQHLTVATLEERPFVIVEPADPISGTCIRDSVPCR-SQL-------------------------- 466

  Fly   211 ANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNF 275
                .||      ||||                    ....:.:.|...|....:|..|:..:.|
Human   467 ----NRT------HSPP--------------------PDAPRPEKRCCKGFCIDILKRLAHTIGF 501

  Fly   276 RFK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLA 339
            .:. |:...|:        .||..:..:.|.||.:...:||..:|.:.::.||.:.::|| ....
Human   502 SYDLYLVTNGK--------HGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFS-VPFV 557

  Fly   340 DSGAFATHAPRRLNEAL---AIMRPFKQDIWPHLI---LTII--------FSGPIFYGIIALPYI 390
            ::|.....|  |.|..:   |.:.|:...:|..:.   ||::        :..|:.|.       
Human   558 ETGISVMVA--RSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYN------- 613

  Fly   391 WRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQ--KCIWFTLRLFLKQ 453
                                               |::.:..:.....|.  |.||....|....
Human   614 -----------------------------------RSLATGKRPGGSTFTIGKSIWLLWALVFNN 643

  Fly   454 SCN-ELHNGYRAKFLTIVYWIAATYVLADVYSAQLTS-----------------QFARPARE-PP 499
            |.. |...|..:|.:.:|:...|...||. |:|.|.:                 :|.||..: ||
Human   644 SVPVENPRGTTSKIMVLVWAFFAVIFLAS-YTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPP 707

  Fly   500 I 500
            :
Human   708 L 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir40aNP_610140.4 Lig_chan-Glu_bd <265..336 CDD:463166 17/71 (24%)
Periplasmic_Binding_Protein_Type_2 297..>391 CDD:473866 21/107 (20%)
Periplasmic_Binding_Protein_Type_2 <496..637 CDD:473866 2/6 (33%)
GRIN2DNP_000827.2 PBP1_iGluR_NMDA_NR2 49..413 CDD:380601 21/113 (19%)
PBP2_iGluR_NMDA_Nr2 430..830 CDD:270436 66/390 (17%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:Q00960 631..650 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 900..934
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 981..1123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1225..1336
PDZ-binding. /evidence=ECO:0000250 1334..1336
Blue background indicates that the domain is not in the aligned region.

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