Protein Alignment Ir40a and GRIN2B

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_000825.2
• Gene: GRIN2B / 2904
• HGNCID: 4586
• Length: 1484
• Species: Homo sapiens
• Alignment Length: 810
• Identity: 140/810 - (17%)
• Similarity: 253/810 - (31%)
• Gaps: 306/810 - (37%)

  Fly    28 DESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLDDFLQRLHRSNY------KSV 86
            |:.|:.|          |:.|..|..|.:.|   .|.||...|:.:....:..:.|      .|:
Human   210 DDGDSKI----------QNQLKKLQSPIILL---YCTKEEATYIFEVANSVGLTGYGYTWIVPSL 261

  Fly    87 VFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIR 151
            |...|:                 ::..:.|..|::..:|.            |....|     .|
Human   262 VAGDTD-----------------TVPAEFPTGLISVSYDE------------WDYGLP-----AR 292

  Fly   152 FREPLRVVV------------VTRPRKKAF-----RIYYNQARPCSDSQLQLVNWY------DGD 193
            .|:.:.::.            :..|:...:     |||          |..::|.|      :|.
Human   293 VRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIY----------QSNMLNRYLINVTFEGR 347

  Fly   194 NL-----GLQRIPLLPTAL-------SVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNS 246
            ||     |.|..|.|...|       .....:|.::.::..:     .|...|..:.|::::..|
Human   348 NLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYY-----VWPRMCPETEEQEDDHLS 407

  Fly   247 LDSIEK-----------------------RKVRVTGGRDHR---------------LLMLLSKHM 273
            :.::|:                       :|..||..:...               :|..:||.:
Human   408 IVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSV 472

  Fly   274 NFRFK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSF-- 335
            .|.:. |:...|:        .||..|.::.|.||.:...:|...:|.:.::.||.:.::||.
Human   473 KFTYDLYLVTNGK--------HGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPF 529

  Fly   336 ----FTLADSGAFATHAPRRLNEALAIMRPFKQDIW--PHLILTIIFSGPIFYGIIALPYIWRRR 394
                .::..|.:..|.:|.      |.:.||..|:|  ..::|.|:.:..:|......|..:.|.
Human   530 IETGISVMVSRSNGTVSPS------AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRC 588

  Fly   395 WANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELH 459
            .|  |....|.                             |.....|.||....|....|. .:.
Human   589 LA--DGREPGG-----------------------------PSFTIGKAIWLLWGLVFNNSV-PVQ 621

  Fly   460 N--GYRAKFLTIVYWIAATYVLADVYSAQLTS-----------------QFARPAR-EPPINTLQ 504
            |  |..:|.:..|:...|...||. |:|.|.:                 :|.||.. .||
Human   622 NPKGTTSKIMVSVWAFFAVIFLAS-YTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPP----- 680

  Fly   505 RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALM---RQQVINDP---------QGFFID 557
                      :|.......|:...:.|.   :.:::|.|   .|:.::|.         ..|..|
Human   681 ----------FRFGTVPNGSTERNIRNN---YAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYD 732

  Fly   558 SV--------EAGIKLIAEG-GEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGC 613
            :.        :.|.||:..| |:..|..|           ||                :|:|...
Human   733 AAVLNYMAGRDEGCKLVTIGSGKVFASTG-----------YG----------------IAIQKDS 770

  Fly   614 PFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISP 678
            .:...::..::|||..|            :.:|:||..: .|....:.:|..|          |.
Human   771 GWKRQVDLAILQLFGDG------------EMEELEALWL-TGICHNEKNEVMS----------SQ 812

  Fly   679 LNLRMLQGAFIALGVGSLAAGVILLLEIVF 708
            |::..:.|.|..||.....:.:..:.|.:|
Human   813 LDIDNMAGVFYMLGAAMALSLITFICEHLF 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	18/77 (23%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	22/101 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	26/162 (16%)
GRIN2B	NP_000825.2	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	39/234 (17%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	88/504 (17%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94	604..623		5/19 (26%)
		NMDAR2_C	840..1484	CDD:463148	1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1074..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding. /evidence=ECO:0000250	1482..1484