Protein Alignment Ir40a and GRIN2A

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 804
• Identity: 146/804 - (18%)
• Similarity: 240/804 - (29%)
• Gaps: 278/804 - (34%)

  Fly    23 TFIGNDES-----DTAI--ALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLDDFLQRLHR 80
            :|:|.|..     ||:.  |.||:......||:.:|          .|.|:..|.:....:.|..
Human   246 SFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILL----------YCSKDEAVLILSEARSLGL 300

  Fly    81 SNY------KSVVFSQTELFFQHIEENLQGAN---------------------------ECISLI 112
            :.|      .|:|...|||..:.....|...:                           |..|.|
Human   301 TGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYI 365

  Fly   113 ----------LDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIRFRE------PLRVVVV 161
                      ::.|...:::||.           |.....|  ..:.:.|.|      |..||:|
Human   366 PEAKASCYGQMERPEVPMHTLHP-----------FMVNVTW--DGKDLSFTEEGYQVHPRLVVIV 417

  Fly   162 TR-----------------------PRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRI-PL 202
            ..                       ||.|:|    :...| .|:.|.:|...:...:.::.| ||
Human   418 LNKDREWEKVGKWENHTLSLRHAVWPRYKSF----SDCEP-DDNHLSIVTLEEAPFVIVEDIDPL 477

  Fly   203 LPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNS------LDSIEKRKVRVTGGR 261
            ..|.               |.::.|.......|||..|......      :|.::|
Human   478 TETC---------------VRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKK--------- 518

  Fly   262 DHRLLMLLSKHMNFRFK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSW 325
                   ||:.:.|.:. |:...|:        .||..|:.:.|.||.:...:|...:|.:.::.
Human   519 -------LSRTVKFTYDLYLVTNGK--------HGKKVNNVWNGMIGEVVYQRAVMAVGSLTINE 568

  Fly   326 ERRKAIEFSF------FTLADSGAFATHAPRRLNEALAIMRPFKQDIW--PHLILTIIFSGPIFY 382
            ||.:.::||.      .::..|.:..|.:|.      |.:.||...:|  ..::|.|:.:..:|.
Human   569 ERSEVVDFSVPFVETGISVMVSRSNGTVSPS------AFLEPFSASVWVMMFVMLLIVSAIAVFV 627

  Fly   383 GIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTL 447
            .....|..:.|..|.....|                               .|.....|.||...
Human   628 FEYFSPVGYNRNLAKGKAPH-------------------------------GPSFTIGKAIWLLW 661

  Fly   448 RLFLKQSCNELHN--GYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAM 510
            .|....|. .:.|  |..:|.:..|:...|...||. |:|.|.:...:......:..|...:...
Human   662 GLVFNNSV-PVQNPKGTTSKIMVSVWAFFAVIFLAS-YTANLAAFMIQEEFVDQVTGLSDKKFQR 724

  Fly   511 IHD---GYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDP---------QGFFIDSV---- 559
            .||   .:|.......|:...:.|......|......|:.:.|.         ..|..|:.
Human   725 PHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNY 789

  Fly   560 ----EAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLN 620
                :.|.||:..|          ....|....||                :|:|.|.|:...::
Human   790 KAGRDEGCKLVTIG----------SGYIFATTGYG----------------IALQKGSPWKRQID 828

  Fly   621 NVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQ 685
            ..|:|....|            :.:|:| |....|....:.:|..|          |.|::..:.
Human   829 LALLQFVGDG------------EMEELE-TLWLTGICHNEKNEVMS----------SQLDIDNMA 870

  Fly   686 GAFIALGVGSLAAGVILLLEIVFI 709
            |.|.     .|||.:.|.| |.||
Human   871 GVFY-----MLAAAMALSL-ITFI 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	17/77 (22%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	21/101 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	25/160 (16%)
GRIN2A	XP_016878661.1	PBP1_iGluR_NMDA_NR2	84..439	CDD:380601	36/215 (17%)
		PBP2_iGluR_NMDA_Nr2	455..854	CDD:270436	91/515 (18%)
		NMDAR2_C	891..1516	CDD:463148