Protein Alignment Ir40a and GRIK5

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 784
• Identity: 143/784 - (18%)
• Similarity: 259/784 - (33%)
• Gaps: 225/784 - (28%)

  Fly    29 ESDTAIALTQIVRG--LQQSSLAILAL-----PSLALSDGVCQKERNVYLDDFLQRLHRSNYKSV 86
            :::..:.|.::|||  :.:.:|::..|     |:..|.:....|...:.:|......|....|:.
Human   167 KAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKAS 231

  Fly    87 VFSQTELFFQHIEE-------NLQGANECISLILDEPNQLLNSLH-------------------- 124
            ....|..|:::|..       :|.|..|..|.||.  ..:.|:.|
Human   232 ELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILG--FSMFNTSHPFYPEFVRSLNMSWRENCEA 294

  Fly   125 DRHLGHRLSLFIFYWGAR---------------------------WPPSSRVIRFREPLRVVVVT 162
            ..:||..||..:.:....                           ||..:.::.:...:....:|
Human   295 STYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLT 359

  Fly   163 RPRKKAFRIYYNQARPCSDSQLQLVN-----------WYDGDNLGLQRIPLLPTALSVYANFKGR 216
            .      |:.:|.....::..|:::.           ||....|.:....|........||   :
Human   360 G------RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLAN---K 415

  Fly   217 TFRV-PVFHSP-----PWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNF 275
            |..| .:..:|     |.|.....|..||                    |....:|..|::.:.|
Human   416 TLVVTTILENPYVMRRPNFQALSGNERFE--------------------GFCVDMLRELAELLRF 460

  Fly   276 RFKYIEAPGRTQGSMR-SEDG----KDSNDSFTGGIG-LLQSGQADFFLGDVGLSWERRKAIEFS 334
            |::           :| .|||    .:.|.|:||.:| |:...:||..:....::.||.|.|:||
Human   461 RYR-----------LRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFS 514

  Fly   335 --FFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILT-IIFSGPIFYGIIALPYIWRRRWA 396
              |.||..|..:..|..|:.. ..:.:.||...:|..::|. :..|..:|......||.|
Human   515 KPFMTLGISILYRVHMGRKPG-YFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW----- 573

  Fly   397 NSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQL-----FQKCIWFTLRLFLKQSCN 456
                                      ..|...|.|.  ||.|     ....:||.:..|::|...
Human   574 --------------------------YNPHPCLRAR--PHILENQYTLGNSLWFPVGGFMQQGSE 610

  Fly   457 ELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQ------RLQAAMIHDGY 515
            .:......:.::.|:| |.|.::...|:|.|.:.......|.|:.:..      .::...||.|
Human   611 IMPRALSTRCVSGVWW-AFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAG- 673

  Fly   516 RLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRE 580
                    |::...:|..   .|.|..|...:.:.....|:.|.|.||         ..||..|.
Human   674 --------STMTFFQNSR---YQTYQRMWNYMQSKQPSVFVKSTEEGI---------ARVLNSRY 718

  Fly   581 TLFF--NVQQY----GSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAE 639
            ....  .:.:|    ..|..|:...|.|:...:.:.:|.||...:...::||.|:..|
Human   719 AFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRL------- 776

  Fly   640 YAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLL 704
                  |:...:.::|....|..:..::          .|.:..:.|.||.|..|.:.|..:.::
Human   777 ------EILKRKWWEGGRCPKEEDHRAK----------GLGMENIGGIFIVLICGLIIAVFVAVM 825

  Fly   705 EIVF 708
            |.::
Human   826 EFIW 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	22/78 (28%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	28/97 (29%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	30/152 (20%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	36/241 (15%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	95/473 (20%)