Protein Alignment Ir40a and GRIK4

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 132/696 - (18%)
• Similarity: 235/696 - (33%)
• Gaps: 197/696 - (28%)

  Fly    87 VFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIR 151
            :|:|:..|||                  |..|.||.....:..|     :.:.|   |..|..:.
Human   270 IFNQSHAFFQ------------------EFAQSLNQSWQENCDH-----VPFTG---PALSSALL 308

  Fly   152 FREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNL--GLQRIPLLPTALSVYANFK 214
            |.....||...:...::..|   ..:|.|....|:  |..|.:|  .|:.:.|......:..|.|
Human   309 FDAVYAVVTAVQELNRSQEI---GVKPLSCGSAQI--WQHGTSLMNYLRMVELEGLTGHIEFNSK 368

  Fly   215 GR--TFRVPVFHSPPWFWVTYCNNSFEEDEEF---------------NSLDSIEKRKVRVTGGRD 262
            |:  .:.:.:        :.:..|.|.:..::               |..|::....:.||...:
Human   369 GQRSNYALKI--------LQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILE 425

  Fly   263 HRLLMLLSKHMNFRFKYIEAPGRTQG---SMRSE---------------DG----KDSNDSFTGG 305
            :..|||...|..     :|...|.:|   .|..|               ||    .::|.::||.
Human   426 NPYLMLKGNHQE-----MEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGM 485

  Fly   306 IGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEALAIMRPFKQDIWP 368
            :|.|.:.:||..:..:.::.||.|.|:||  |.||..|..:..|..|:.. ..:.:.||...:|.
Human   486 VGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPG-YFSFLDPFSPGVWL 549

  Fly   369 HLILTIIFSGPIFYGIIAL-PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAH 432
            .::|..:....:.:.:..| ||.|
Human   550 FMLLAYLAVSCVLFLVARLTPYEW----------------------------------------- 573

  Fly   433 QMPHQLFQ-KC------------IWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYS 484
            ..||...| :|            :||.:..|::|...........:.::.|:| |.|.::...|:
Human   574 YSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWW-AFTLIIISSYT 637

  Fly   485 AQLTSQFARPAREPPINTLQRL--QAAM----IHDGYRLYVEKESSSLEMLENGTELFRQLYALM 543
            |.|.:.......:.||.::..|  |.|:    ||.|         ||:...:|..   .|.|..|
Human   638 ANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGG---------SSMTFFQNSR---YQTYQRM 690

  Fly   544 RQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVA 608
            ...:.:.....|:.|.|.||..:........:   ..|:....:|...|..|:...|.|:...:.
Human   691 WNYMYSKQPSVFVKSTEEGIARVLNSNYAFLL---ESTMNEYYRQRNCNLTQIGGLLDTKGYGIG 752

  Fly   609 VQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDS 673
            :.:|..|....:..::||.|:..|             |:...:.::|....|..:..::
Human   753 MPVGSVFRDEFDLAILQLQENNRL-------------EILKRKWWEGGKCPKEEDHRAK------ 798

  Fly   674 TVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKLDQARLWML 719
                .|.:..:.|.|:.|..|.:.|..:.:||.         ||.|
Human   799 ----GLGMENIGGIFVVLICGLIVAIFMAMLEF---------LWTL 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	24/94 (26%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	26/96 (27%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	31/146 (21%)
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	30/170 (18%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	87/445 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956