Protein Alignment Ir40a and Grin3b

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_006513350.1
• Gene: Grin3b / 170483
• MGIID: 2150393
• Length: 1138
• Species: Mus musculus
• Alignment Length: 546
• Identity: 109/546 - (19%)
• Similarity: 201/546 - (36%)
• Gaps: 163/546 - (29%)

  Fly   235 NNSFEEDEEFNSLD--SIEKRKVRVTGGRDHRLLMLLSKHMNFRFK-YIEAPGRTQGSMRSEDGK 296
            |:|...|..|.:|:  |:.:...|...|....||..|::.:.|.|: ||...|: .|::|  ||:
Mouse   531 NDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGK-YGALR--DGR 592

  Fly   297 DSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLADSGAFATHAPRRLNEALAIM-- 359
                 :||.:|.|.:|:|...:....::..|.:.::|:      |..|:|        :|.||
Mouse   593 -----WTGLVGDLLAGRAHMAVTSFSINSARSQVVDFT------SPFFST--------SLGIMVR 638

  Fly   360 -----RPFKQDIWP-HLILTI-IFSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEIT 417
                 .|....:|| |..:.: :|:......:....|.||..:.                   :|
Mouse   639 TRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYG-------------------LT 684

  Fly   418 PRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADV 482
            ||   .:.|..:.::.....|   |...   ||.:...::.......:||..::.|....||:.
Mouse   685 PR---GRNRGTVFSYSSALNL---CYAI---LFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSS- 739

  Fly   483 YSAQLTSQFARPAREPPINTLQRLQAAMIHD--------GYRLYVEKESSSLEMLENGTELFRQL 539
            |:|.|.:.....      .|.:.|..  |||        |:|.....|||:...::..   |.::
Mouse   740 YTANLAAVMVGD------KTFEELSG--IHDPKLHHPSQGFRFGTVWESSAEAYIKAS---FPEM 793

  Fly   540 YALMRQ-----------QVINDP---QGFFID--------SVEAGIKLIAEGGEDKAVLGGRETL 582
            :|.||:           .:.:||   ..|.:|        |::|..||:..|..
Mouse   794 HAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKP----------- 847

  Fly   583 FFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEV 647
             |.::.||                :.:....|...:|:..:.:...||.:|.:    :.|.|:.|
Mouse   848 -FAIEGYG----------------IGLPQNSPLTSNLSEFISRYKSSGFIDLL----HDKWYKMV 891

  Fly   648 EATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKL- 711
            ..           ....::.||:..      :.:..|.|.|:.|.:|..:|.:..|.|.||.:|
Mouse   892 PC-----------GKRVFAVTETLQ------MGVYHLSGLFVLLCLGLGSALLTSLGEHVFYRLV 939

  Fly   712 -------DQARLWMLCSRLQWIRYDR 730
                   ::.:.|:..|:::  |.|:
Mouse   940 LPRIRRGNKLQYWLHTSQVR--RQDK 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	20/71 (28%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	20/102 (20%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	31/170 (18%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	90/450 (20%)
		Lig_chan	654..921	CDD:459656	61/355 (17%)