Protein Alignment Ir40a and Grik3

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001074566.1
• Gene: Grik3 / 14807
• MGIID: 95816
• Length: 919
• Species: Mus musculus
• Alignment Length: 773
• Identity: 149/773 - (19%)
• Similarity: 268/773 - (34%)
• Gaps: 220/773 - (28%)

  Fly     6 ALGLLPYLLGLLNSTRLTFIGNDESD-TAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNV 69
            ||.|.||....:|.|....:..|... :||.....:..||.:..|     ...|.|||...:..:
Mouse   266 ALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWAMERLQAAPRA-----ESGLLDGVMMTDAAL 325

  Fly    70 YLDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLH-DRH----LG 129
            ..|    .:|   ..||.:.:.                        |...:|||. .||    .|
Mouse   326 LYD----AVH---IVSVCYQRA------------------------PQMTVNSLQCHRHKAWRFG 359

  Fly   130 HRLSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPC-SDSQLQLVNWYDGD 193
            .|...||  ..|:|          |.|           ..||.:|:.... :|..|.:::..:.
Mouse   360 GRFMNFI--KEAQW----------EGL-----------TGRIVFNKTSGLRTDFDLDIISLKED- 400

  Fly   194 NLGLQRIPLLPTA--LSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVR 256
              ||:::.:...|  |::....|||        .|                  |..||:..|.:.
Mouse   401 --GLEKVGVWSPADGLNITEVAKGR--------GP------------------NVTDSLTNRSLI 437

  Fly   257 VTGGRDHRLLMLLSK----HMNFRF---------KYIEAPGRTQGSMRSEDGK----DSNDSFTG 304
            ||...:...:|....    :.|.||         :.....|.:......||||    |....:.|
Mouse   438 VTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNG 502

  Fly   305 GIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQDI 366
            .:..|...:||..:..:.::..|.|||:||  |.||..|..:  ..|...|.:: :.:.|...||
Mouse   503 MVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILY--RKPNGTNPSVFSFLNPLSPDI 565

  Fly   367 WPHLILTIIFSGPIFYGIIAL-PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLS 430
            |.:::|..:....:.:.|... ||    .|.::...:.|...:...:              |:|:
Mouse   566 WMYVLLAYLGVSCVLFVIARFSPY----EWYDAHPCNPGSEVVENNF--------------TLLN 612

  Fly   431 AHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPA 495
            :           .||.:...::|....:......:.:..::|. .|.::...|:|.|.:......
Mouse   613 S-----------FWFGMGSLMQQGSELMPKALSTRIIGGIWWF-FTLIIISSYTANLAAFLTVER 665

  Fly   496 REPPINTLQ------RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGF 554
            .|.||::..      :::...:.||..:...|:|.        ...|.:::|.|..:    |..
Mouse   666 MESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSK--------ISTFEKMWAFMSSK----PSA- 717

  Fly   555 FIDSVEAGIK--LIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLG 617
            .:.:.|.||:  |.|    |.|:|....|:.: :.|...|..|:...:.::...:...:|.|:..
Mouse   718 LVKNNEEGIQRTLTA----DYALLMESTTIEY-ITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRD 777

  Fly   618 SLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGS--VQAKNSEAYSRTESYDSTVISPLN 680
            .:...::||.|.   ||:          .:...:.::||  .:.:|.||            |.|.
Mouse   778 KITIAILQLQEE---DKL----------HIMKEKWWRGSGCPEEENKEA------------SALG 817

  Fly   681 LRMLQGAFIALGVGSLAAGVILLLEIVFIKL----------------DQARLWMLCSR 722
            ::.:.|.||.|..|.:.:.::.:.|.:: ||                |:.|..:.|.|
Mouse   818 IQKIGGIFIVLAAGLVLSVLVAVGEFIY-KLRKTAEREQRSFCSTVADEIRFSLTCQR 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	20/89 (22%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	25/97 (26%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	30/148 (20%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate	37..417	CDD:380605	44/212 (21%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	79/430 (18%)