Protein Alignment Ir40a and Grik2

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_011241422.1
• Gene: Grik2 / 14806
• MGIID: 95815
• Length: 943
• Species: Mus musculus
• Alignment Length: 719
• Identity: 131/719 - (18%)
• Similarity: 249/719 - (34%)
• Gaps: 163/719 - (22%)

  Fly    81 SNYKSVVFSQTELFFQHIEE-NLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWP 144
            :.|...:|:..:||...:|. ...|.|.....||:..|..::|:.::....||..         |
Mouse   249 TEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQA---------P 304

  Fly   145 P-----------SSRVIRFREPLRVVVVT---RPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNL 195
            |           ::......:.:.||.|.   .|:.....:..|:.:|          |..|...
Mouse   305 PKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKP----------WRFGTRF 359

  Fly   196 GLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEE-------------FNSL 247
                     .:|...|:::|.|.|: .|:........:..:.....||             .|..
Mouse   360 ---------MSLIKEAHWEGLTGRI-TFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPSSGLNMT 414

  Fly   248 DSIEKRKVRVTGGRDHRLLML--LSKHMNFRFKYIEAP----------------------GRTQG 288
            :|.:.:...:|....:|.|::  :.:.....||..:.|                      |.|..
Mouse   415 ESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYE 479

  Fly   289 SMRSEDGK-----DSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFAT 346
            ....||||     |.|..:.|.:..|...:||..:..:.:::.|.|.|:||  |.||..|..:
Mouse   480 IRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY-- 542

  Fly   347 HAPRRLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHM 410
            ..|...|..: :.:.|...|||.:::|.       :.|:..:.::..|:...|..::....:.|.
Mouse   543 RKPNGTNPGVFSFLNPLSPDIWMYILLA-------YLGVSCVLFVIARQSKFSWFKYPNCSHYHH 600

  Fly   411 TYLKEITPRLLKLKPRTVLSAHQM--PHQ------------LFQKCIWFTLRLFLKQSCNELHNG 461
            :.....|..|.......:.|.::.  ||.            ......||.:...::|....:...
Mouse   601 SQRCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKA 665

  Fly   462 YRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQ------RLQAAMIHDGYRLYVE 520
            ...:.:..::|. .|.::...|:|.|.:.......|.||::..      :::...:.||..:...
Mouse   666 LSTRIVGGIWWF-FTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFF 729

  Fly   521 KESSSLEMLENGTELFRQLYALM---RQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETL 582
            |:|.        ...:.:::|.|   ||.|:       :.|.|.||:.:..  .|.|.|....|:
Mouse   730 KKSK--------ISTYDKMWAFMSSRRQSVL-------VKSNEEGIQRVLT--SDYAFLMESTTI 777

  Fly   583 FFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEV 647
            .| |.|...|..|:...:.::...|...:|.|:...:...::||.|.|.|..|....:..
Mouse   778 EF-VTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRG----- 836

  Fly   648 EATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKLD 712
                  .|..:.::.||            |.|.::.:.|.||.|..|.:.:..:.:.|.::....
Mouse   837 ------NGCPEEESKEA------------SALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKK 883

  Fly   713 QARL 716
            .|:|
Mouse   884 NAQL 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	21/101 (21%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	23/96 (24%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	34/149 (23%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	32/193 (17%)
		Periplasmic_Binding_Protein_Type_2	430..835	CDD:473866	84/432 (19%)