Protein Alignment Ir40a and Grid2

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_032193.1
• Gene: Grid2 / 14804
• MGIID: 95813
• Length: 1007
• Species: Mus musculus
• Alignment Length: 907
• Identity: 154/907 - (16%)
• Similarity: 286/907 - (31%)
• Gaps: 328/907 - (36%)

  Fly    16 LLNSTRLTFI-----GNDE-----------SDTAIALTQIVRGLQQSSLAILA----LPSLALSD 60
            :|.:.::||.     ||:.           :...:||...:......||..||    :|.|.:..
Mouse    57 ILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQR 121

  Fly    61 ----------GVCQKERN----------VYLDDFLQRLHRSNY---KSVVFSQTELFFQHIEENL 102
                      |:.:..||          |||::.:.|: .:.|   |.::|..:|...:.|:|.|
Mouse   122 STAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEVILRV-VTEYAWQKFIIFYDSEYDIRGIQEFL 185

  Fly   103 -----QGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIRFREPLR--VVV 160
                 ||.:..:..:.:..|:::.:|.|......|:                 |:|:.||  ::|
Mouse   186 DKVSQQGMDVALQKVENNINKMITTLFDTMRIEELN-----------------RYRDTLRRAILV 233

  Fly   161 VTRPRKKAF---------------RIYYNQARPCSDSQLQLVNWYDGDNL---GLQRIPLLPTAL 207
            :.....|:|               .|..|:.          :|..|...|   .:.|:.::....
Mouse   234 MNPATAKSFISEVVETNLVAFDCHWIIINEE----------INDVDVQELVRRSIGRLTIIRQTF 288

  Fly   208 SVYANFKGRTFR----------------------------------VPVFH-------------- 224
            .|..|...|.||                                  ...||
Mouse   289 PVPQNISQRCFRGNHRISSSLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASL 353

  Fly   225 ------SPPW------------------------------------------------------F 229
                  |.||                                                      .
Mouse   354 SCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGC 418

  Fly   230 W--VTYCNNSFEEDEEFNSLDSIEKRKVRVTG-----------GRDHR-------LLMLLSKHMN 274
            |  ||..|.|..:.:..|::..:..|.|.|..           |:..:       :|..||.::.
Mouse   419 WNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLG 483

  Fly   275 FRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLA 339
            |.::...||....||.: |||     ::.|.:|.|...:||..:..:.::.:|...::|:...:.
Mouse   484 FNYEIYVAPDHKYGSPQ-EDG-----TWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMD 542

  Fly   340 DSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDVEHLG 404
            .|.........:..:..|.:.||...:|..:..|::..|.:.|.:         .|.|
Mouse   543 YSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL---------NWLN------- 591

  Fly   405 ELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTI 469
                               .||  |....|........:||....|::|.....:.....:.:..
Mouse   592 -------------------PPR--LQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMG 635

  Fly   470 VYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQA------AMIHDGYRLYVEKESSSLEM 528
            .:|:.|..|::. |:|.|.:.......|..|.:||.|..      ..:.|. .:|.......|..
Mouse   636 AWWLFALIVISS-YTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDS-AVYQHVRMKGLNP 698

  Fly   529 LENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGE----DKAVLGGRETLFFNVQQY 589
            .|..: ::.|::.::.:.  |..:...::| :|||:.:..|..    |.|||           :|
Mouse   699 FERDS-MYSQMWRMINRS--NGSENNVLES-QAGIQKVKYGNYAFVWDAAVL-----------EY 748

  Fly   590 GSNN------FQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQ----- 643
            .:.|      :.:...:..|...:|:|.|.|:....:..:::|.:||.:|.:....:.|.
Mouse   749 VAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDL 813

  Fly   644 YQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLE 705
            |..|:|.:  ||..                     |:::.|.|.|..|..|.:.:.:|.:||
Mouse   814 YSSVDAKQ--KGGA---------------------LDIKSLAGVFCILAAGIVLSCLIAVLE 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	18/70 (26%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	15/93 (16%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	31/156 (20%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		53/315 (17%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	60/399 (15%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	77/425 (18%)
		Interaction with AP4M1. /evidence=ECO:0000250|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007