Protein Alignment Ir40a and Grid1

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_032192.2
• Gene: Grid1 / 14803
• MGIID: 95812
• Length: 1009
• Species: Mus musculus
• Alignment Length: 734
• Identity: 135/734 - (18%)
• Similarity: 241/734 - (32%)
• Gaps: 188/734 - (25%)

  Fly    24 FIGNDESDTAIALTQIVRGLQQSSLAILALPSL-----------ALSDGVCQKERNVYLDDFLQR 77
            |:..:.||..| |..:...|.:.::.....||.           .:|..:|..:     :.:||.
Mouse   257 FVNEEISDPEI-LDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQ-----EGYLQM 315

  Fly    78 LHRSN---YKSVVFSQTELFFQHIEE---NLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFI 136
            |..||   |.||:. ....|.:.:|:   :...:..||.......|...:.|.....||...|
Mouse   316 LQISNLYLYDSVLM-LANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGL-- 377

  Fly   137 FYWGARWPPSSRVIRFREP-----LRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNW--YDGDN 194
                      :.|:.|||.     ::..::.....:.|          .....:|..|  ..|.|
Mouse   378 ----------TGVMEFREDSSNPYVQFEILGTTYSETF----------GKDMRKLATWDSEKGLN 422

  Fly   195 LGLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTG 259
            ..||..|:       .:..:|.|.:|......|  :|....|...:.:.:... ||:
Mouse   423 GSLQERPM-------GSRLQGLTLKVVTVLEEP--FVMVAENILGQPKRYKGF-SID-------- 469

  Fly   260 GRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDS----NDSFTGGIGLLQSGQADFFLGD 320
                 :|..|:|.:.|:::..:||          ||:..    |.|:.|.||.|.|.:||..:..
Mouse   470 -----VLDALAKALGFKYEIYQAP----------DGRYGHQLHNTSWNGMIGELISKRADLAISA 519

  Fly   321 VGLSWERRKAIEFSFFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGII 385
            :.::.||...::||...:..|.......|.......::..||...:|..:...|...|.:.:
Mouse   520 ITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIF--- 581

  Fly   386 ALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLF 450
                                          :..|:..::.::...............||.....|
Mouse   582 ------------------------------VLNRIQAVRSQSATQPRPSASATLHSAIWIVYGAF 616

  Fly   451 LKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAM----- 510
            ::|......|....:.:...:|: .|.::...|:|.|.:.......:.||.|.|.|...:
Mouse   617 VQQGGESSVNSVAMRIVMGSWWL-FTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYG 680

  Fly   511 -IHDG--YRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGE- 571
             :.|.  |..:..|.::.||......||:|.:..       |......:.:...||:...:|..
Mouse   681 TVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISK-------NGGADNCVSNPSEGIRKAKKGNYA 738

  Fly   572 ---DKAVLGGRETLFFNVQQYGS-----------NNFQLSQKLYTRYSAVAVQIGCPFLGSLNNV 622
               |.||:           :|.:           .| .:|.|.|    .:|:|.|.|:....:..
Mouse   739 FLWDVAVV-----------EYAALTDDDCSVTVIGN-SISSKGY----GIALQHGSPYRDLFSQR 787

  Fly   623 LMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGA 687
            :::|.::|.||.:      ||.......|....|..:..:|..|            |.|....|.
Mouse   788 ILELQDTGDLDVL------KQKWWPHTGRCDLTSHSSTQTEGKS------------LKLHSFAGV 834

  Fly   688 FIALGVGSLAAGVILLLEI 706
            |..|.:|.|.|.::..||:
Mouse   835 FCILAIGLLLACLVAALEL 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	21/74 (28%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	20/97 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	33/163 (20%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269|PubMed:27418511	21..436		39/214 (18%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	36/196 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	82/458 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960