Protein Alignment Ir40a and GRIN3B

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 98/509 - (19%)
• Similarity: 179/509 - (35%)
• Gaps: 153/509 - (30%)

  Fly   265 LLMLLSKHMNFRFK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERR 328
            ||..|::...|.|: |:...|: .|::|  ||:     :||.:|.|.:|:|...:....::..|.
Human   483 LLERLAEDTPFDFELYLVGDGK-YGALR--DGR-----WTGLVGDLLAGRAHMAVTSFSINSARS 539

  Fly   329 KAIEFSFFTLADSGAFATHAPRRLNEALAIM-------RPFKQDIWP-HLILTI-IFSGPIFYGI 384
            :.::|:      |..|:|        :|.||       .|....:|| |....: :|:......:
Human   540 QVVDFT------SPFFST--------SLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTAL 590

  Fly   385 IALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRL 449
            ....|.||..:.                   :|||   .:.|:.:.::.....|   |.....|.
Human   591 FLTVYEWRSPYG-------------------LTPR---GRNRSTVFSYSSALNL---CYAILFRR 630

  Fly   450 FLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHD- 513
            .:.....:...|.    |.:..|.....::...|:|.|.:.....      .|.:.|..  |||
Human   631 TVSSKTPKCPTGR----LLMNLWAIFCLLVLSSYTANLAAVMVGD------KTFEELSG--IHDP 683

  Fly   514 -------GYRLYVEKESSSLEMLENGTELFRQLYALMRQ-----------QVINDP---QGFFID 557
                   |:|.....|||:...::..   |..::|.||:           .:.:||   ..|.:|
Human   684 KLHHPAQGFRFGTVWESSAEAYIKKS---FPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMD 745

  Fly   558 --------SVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCP 614
                    |::|..||:..|..            |.::.||                :.:....|
Human   746 KSLLDYEVSIDADCKLLTVGKP------------FAIEGYG----------------IGLPQNSP 782

  Fly   615 FLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPL 679
            ...:|:..:.:...||.:|.:    :.|.|:.|..           ....::.||:..      :
Human   783 LTSNLSEFISRYKSSGFIDLL----HDKWYKMVPC-----------GKRVFAVTETLQ------M 826

  Fly   680 NLRMLQGAFIALGVGSLAAGVILLLEIVFIKLDQARLWMLCSRLQ-WIRYDRKV 732
            ::....|.|:.|.:|..:|.:..|.|..|.:|...|: ...|||| |:...:|:
Human   827 SIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRI-RKGSRLQYWLHTSQKI 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	19/71 (27%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	20/102 (20%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	31/170 (18%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	29..401	CDD:380600
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	78/418 (19%)
		Lig_chan	574..841	CDD:459656	57/355 (16%)