Protein Alignment Ir40a and LOC11175900

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_003437077.2
• Gene: LOC11175900 / 11175900
• VectorBaseID: AGAMI1_003275
• Length: 652
• Species: Anopheles gambiae
• Alignment Length: 754
• Identity: 154/754 - (20%)
• Similarity: 274/754 - (36%)
• Gaps: 208/754 - (27%)

  Fly    25 IGNDESDTAI-ALTQ-IVRGLQQSSLAILALPSLALSDGVCQKERNVYLDDFLQRLHRS---NYK 84
            :||..|:..: |||: .|:  ..||..::.|.:  :|||....:.:: :|:.:||..||   .::
Mosquito    34 VGNHLSEVIVNALTRYYVQ--NHSSTQVMRLST--VSDGTYDLQSDI-MDEVMQRTSRSIAYEFR 93

  Fly    85 SVVF-SQTELFFQHIEENLQGANECISLILDEPNQLLNSL---HDRHLGHRLSLFIFYWGARWPP 145
            |.:. |:....|.....:..||.|          ||..||   .:...|:.|.:...| |.|..|
Mosquito    94 SALGPSRRPRIFNIAFVDGYGAFE----------QLFRSLDPAENDFAGYYLIVLTAY-GRRIAP 147

  Fly   146 S--SRVIRFREPLRVVVV----------TRPRKKAFRIY--YNQARPCSDSQLQLVNWY-DGDNL 195
            .  :|:......:.|:.|          :|.:......|  |.....|......|::.: .|..|
Mosquito   148 DTLARIFALLWTMNVINVNIVSADLEDQSRWQSVLMHTYYPYRAGGNCERIVPHLLHRFRKGQRL 212

  Fly   196 GLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGG 260
            . :.:.|.|:.||   |..|....|..||.||:..:|....                     .||
Mosquito   213 D-RSVELFPSKLS---NLHGCPVTVGTFHLPPYMLLTPAGR---------------------YGG 252

  Fly   261 RDHRLLMLLSKHMNFRFKYI-----EAPGRTQG-------SMRSEDGKDSNDSFTGGIGLLQSGQ 313
            .:..||..||:.:||..:.:     |..|||..       :.|:..|.   .|.:|.:.|:.:.:
Mosquito   253 LEGDLLRALSRKLNFTVRLVVPDDGELWGRTPSPSVVVADANRTRGGA---SSASGCVRLVLTER 314

  Fly   314 ADFFLGDVGLSWERRKAIEF--SFFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIF 376
            .:..||...:..:|...::.  |::|:  ....|..|.|.......:.|||.:.:|. |:...:.
Mosquito   315 VNLTLGRFAIRGDRNLVMKSSRSYYTV--RMVLAVPAGREYTPFEKLFRPFSRSVWV-LVTLYLL 376

  Fly   377 SGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVL---SAHQMPHQL 438
            :|.:..|.:.|.:    |.|..|          ..|.:.::..:|.|  .:||   :..|:|.:.
Mosquito   377 AGMVVIGTVQLLH----RPAVRD----------FVYGRGVSTPVLNL--LSVLFGGAVVQLPMRN 425

  Fly   439 FQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTL 503
            |.:.:     |||                    |:....|:...|...|...........|:.|:
Mosquito   426 FARTL-----LFL--------------------WMYYCLVVRTCYQGSLYEYLQERKNFSPLQTV 465

  Fly   504 QRLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGI-KLIA 567
            .    |::.:.||.|      ||    :||.|:.:....:..::.      ::...:|.: :|:.
Mosquito   466 D----ALVRNDYRFY------SL----HGTSLYLEQMPQILSRIT------WLPDDDASVDRLLT 510

  Fly   568 EGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGI- 631
            |....:|:   ...||.::::...:|     :.|.|...|.:.          ||::.....||
Mosquito   511 ELATRQAL---TSALFIDLERVAYHN-----RFYVRGGLVYIA----------NVVLVRLPIGIY 557

  Fly   632 --------------LDKMTAAEYAK----QYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISP 678
                          ||::..:.|..    .|...:|   :||....:             .:.:|
Mosquito   558 YPKKSCLANRFDHELDRLRTSGYVSYRLGHYLNYDA---FKGPADYQ-------------PLPTP 606

  Fly   679 LNLRMLQGAFIAL-GVGSLAAGVILLLEIV---FIKLDQ 713
            |....|.|.:..| |:..:|.| :||||:.   |:.|.|
Mosquito   607 LTTDQLVGCYETLFGLLLVATG-LLLLELASRWFVSLRQ 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	19/84 (23%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	19/95 (20%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	27/156 (17%)
LOC11175900	XP_003437077.2	None