DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1428 and R03G8.1

DIOPT Version :9

Sequence 1:	NP_610127.1	Gene:	CG1428 / 35433	FlyBaseID:	FBgn0032967	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_510172.2	Gene:	R03G8.1 / 187544	WormBaseID:	WBGene00010996	Length:	663	Species:	Caenorhabditis elegans

Alignment Length:	588	Identity:	132/588 - (22%)
Similarity:	234/588 - (39%)	Gaps:	113/588 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SEDLSCRYWLKSGHTRNHSGHYTAYGHFDLKRGATRKIKIGTGEQIVRIRCSDKFKASKYHDVLY 162
            :.:|:||   ...|||..... ...|::....|     ||..  :|:...|::  |..:..||..
Worm   101 AHNLTCR---ARCHTRKRDKE-NLVGNWTYTPG-----KINC--EILETVCAE--KGGEQRDVYG 152

  Fly   163 FLS----PPDPKLMSTESS-EKLSVMVLGIDSVSHMHFVRYFPLVMAFLENHPHTKFFGY-SRVG 221
            :|.    |..|||..|.:. ::..|.|:.:||:|:....|..|..::|.:::.....|.| ::||
Worm   153 YLHSQIIPTKPKLSRTNADLKEYDVFVILLDSLSYSQAARSLPRTVSFFKSYMKGIIFPYMNKVG 217

  Fly   222 LDANANLVPFLGGK-------------SSRAAGSD-----ILSDEKAWLWDSFKMEGYSTAYGED 268
            .::..|.|....||             |..|..:|     :..|.:..|:|.||..||.|...||
Worm   218 DNSRPNGVALWFGKLLEKVDRFIFDKPSLEADWTDDYFCNVFKDNETSLFDEFKTHGYKTLMAED 282

  Fly   269 NAKG------ILSNRNGDKELPKSPVDFDLTPVIVEMNNHTRYSIDL-KEMIHCTAGRKFQDVLR 326
            .|.|      .|..||       ..:|..:.|..:.   |.:|...: :|.::.:..|:..:.|.
Worm   283 WALGTLIWPNCLGYRN-------QSIDHYMRPFQLA---HEKYGTPVTREHLNGSLCREDHNTLL 337

  Fly   327 DFVLQLV-----------------PYMQGMPFFSFFWQSQGVQEYYEYAWHLDLSYMMLLKKLLD 374
            |::.|.:                 |.......|:|.|.::        ..|...:.....:...|
Worm   338 DYLAQFLDAYSGSNDSIQLKREKSPNSPDQRKFAFLWTTR--------LGHATENGFDATENGSD 394

  Fly   375 ADILN----------NTLLFLMSDHGLRAGEYRMSLQGMKEESQPLMVAIYPEWLKRKYPLAVGN 429
            .|.||          ::.:.|:.|||.|.|..|.:..|..:.:.||.....|..|:....: :..
Worm   395 NDFLNFFIKHRKKLEDSFVLLLGDHGFRLGGVRNTAVGAIDVNNPLTAISVPNSLRTNTDI-LKI 458

  Fly   430 LESNAHSLITPYDLRETLADVIALGQLKDAN----IEVSMKRLQSHPPNRLPRGISLFLPIPDHR 490
            |..|:..|.|.:|.|.|:.|::.....:..:    :::..::.|||..|:         | |.:|
Worm   459 LNMNSEKLQTHFDTRATILDILKFQPAEKFSAITPLQIPGEKGQSHLRNQ---------P-PFNR 513

  Fly   491 TCDLAHIPSLFCFCR-ELTEVPTDDGLVLRSSRFMVESINQL--IKPF-GQCRQLKLEMV--LLA 549
            .|....||..:|.|: ..|.||.:..:.:.....:.|::|:|  |..| .:|..:..|..  ||.
Worm   514 NCQTMPIPFEYCICQFNKTSVPINSTISMEIGEKVAENVNKLLQINNFTSECISMVFERTESLLQ 578

  Fly   550 HFLDFGEESFVYELRLRVRTSPGNGVYEATVRLSD-VLLLTSPISRVSHYLGQSHCIGDPDLQIF 613
            :....| .|.:|.:..::: .|....::|||:::: .:.:.|.:.||..|...:.||.....:..
Worm   579 YNQKLG-NSTIYTVIAQMK-KPSEAKFKATVKITEGNIKIVSKVERVDSYGKTADCIESETHRPI 641

  Fly   614 CLC 616
            |.|
Worm   642 CYC 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1428	NP_610127.1	DUF229	68..547	CDD:281053	115/516 (22%)
CG1428	NP_610127.1	ALP_like	180..453	CDD:293745	72/325 (22%)
R03G8.1	NP_510172.2	DUF229	74..651	CDD:281053	132/588 (22%)
R03G8.1	NP_510172.2	ALP_like	175..483	CDD:293745	72/326 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28588
OrthoDB	1	1.010	-	-		D306348at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.990