DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and ZNF644

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	XP_005271314.1	Gene:	ZNF644 / 84146	HGNCID:	29222	Length:	1368	Species:	Homo sapiens

Alignment Length:	1063	Identity:	210/1063 - (19%)
Similarity:	340/1063 - (31%)	Gaps:	408/1063 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LITGKQNASPKTD--GRTRISADTHVSA--------TLISSSNLDHSYDGFHFTEPEAPSSYLRK 88
            |.||:....|.|:  ...:::||..:|.        .|...|::.|:.:..|       |:....
Human   138 LTTGQPVDQPTTESCSTLKVAADLQLSTPQKASQHQVLFLLSDVAHAKNPTH-------SNKKLP 195

  Fly    89 TAASHG-------GKTSKS---LTEAYDLPYELGADLFFSSLQLQSVATGGKIGSVPRQERSK-D 142
            |:||.|       |...||   |....::. |.|.||......:.:| ||  |.|.....||: |
Human   196 TSASVGCDIQNSVGSNIKSDGTLINQVEVG-EDGEDLLVKDDCVNTV-TG--ISSGTDGFRSEND 256

  Fly   143 ESWSAPAGDP---LLKAVRENDETVFK-PLH-------------------------FDHE--YPE 176
            .:|     ||   .::.:..|:|||.| |.|                         |...  .|.
Human   257 TNW-----DPQKEFIQFLMTNEETVDKAPPHSKIGLEKKRKRKMDVSKITRYTEDCFSDSNCVPN 316

  Fly   177 AS--DEEDDEDEHEEFDA----------------EEDEEEYDARRH-----------SPPIVPAS 212
            .|  .|.|..:::||..|                :||.|..||.:|           |.|:
Human   317 KSKMQEVDFLEQNEELQAVDSQKYALSKVKPESTDEDLESVDAFQHLIYNPDKCGEESSPV---- 377

  Fly   213 HTGGKWKPEQRPQLRHPHIERLSPSWDEPPEENYTHPPADHTKGKWVPGSKQLEYRENLDLTKLD 277
            ||.                ..||.:..:..||:.:..||..:                     .:
Human   378 HTS----------------TFLSNTLKKKCEESDSESPATFS---------------------TE 405

  Fly   278 QPGASYWCNICCRRLKSRLYYNQHLRSGYHIKRAEAECELEQATLGRELTLSKDFSIKDDADKNE 342
            :| :.|.|..|....:.:.:.::|:.  ||         |:..:..|.|              |.
Human   406 EP-SFYPCTKCNVNFREKKHLHRHMM--YH---------LDGNSHFRHL--------------NV 444

  Fly   343 PKPPKRQRRANLLRCDLCRHTMA-RHLIGKHLISHYHFRRLQQQSRIRRQACLQEI--LKHMGSI 404
            |:|         ..|..|..|.. |:.:.||:|.|..          |||..::||  ||.:...
Human   445 PRP---------YACRECGRTFRDRNSLLKHMIIHQE----------RRQKLMEEIRELKELQDE 490

  Fly   405 VRQSPFQCMPCRFYANTEETFLYHWKSHEHLELTKRLGGTFWCSFCQFNSNTNNSMLLHLLDSSH 469
            .|.:..||..|.|..|..:||:.|.|:||.   .||.   :.|..|.|.:.|.|.:..| ...:|
Human   491 GRSARLQCPQCVFGTNCPKTFVQHAKTHEK---DKRY---YCCEECNFMAVTENELECH-RGIAH 548

  Fly   470 KEVLLALNRSVPIC---IAQRRRIQ-------------------CSRCGM------------EFL 500
            ..|:     ..|:.   ||||:..:                   |..|..            |:|
Human   549 GAVV-----KCPMVTSDIAQRKTQKKTFMKDSVVGSSKKSATYICKMCPFTTSAKSVLKKHTEYL 608

  Fly   501 YN------------IQLRQHSITEHP-GLALTGTAADEYQSRFRCNLC---------GSSQKSRL 543
            ::            :..|::.|.|.| ....|.|...:..:.|..|..         ||:.:|..
Human   609 HSSSCVDSFGSPLGLDKRKNDILEEPVDSDSTKTLTKQQSTTFPKNSALKQDVKRTFGSTSQSSS 673

  Fly   544 ALQRHKK-HKHHLARYFCA-----IC--------RLEFDNSLDAR-------------------- 574
            ..:.||: |:...||...|     :|        .:...:|:|.:
Human   674 FSKIHKRPHRIQKARKSIAQSGVNMCNQNSSPHKNVTIKSSVDQKPKYFHQAAKEKSNAKANSHY 738

  Fly   575 --RHR------------SLVIH--KQKARPQTSI----------------------PQPENEIEH 601
              ||:            |..:|  |::|....|:                      .:||:..:|
Human   739 LYRHKYENYRMIKKSGESYPVHFKKEEASSLNSLHLFSSSSNSHNNFISDPHKPDAKRPESFKDH 803

  Fly   602 ---MLREVLEETVPSPPAKRSADVNAKCSNS------RKTIESSQRL--AQHQAEVHSSDNHLCL 655
               .::.|::|      :|:.:.|..:..:|      :.|:...|:|  |:.:....:.|..
Human   804 RRVAVKRVIKE------SKKESSVGGEDLDSYPDFLHKMTVVVLQKLNSAEKKDSYETEDES--- 859

  Fly   656 SCGISFESAQALGRHTRSCQPLASTSTPADLSQAQ-----------------KKSMYSCDQ-CRF 702
                |:::.: ||.:|...   ....|.:|::|..                 :.:..|.|| ..|
Human   860 ----SWDNVE-LGDYTTQA---IEDETYSDINQEHVNLFPLFKSKVEGQEPGENATLSYDQNDGF 916

  Fly   703 QSQYESDLVYHRIFH---------TRSGTIGKN-----------EVLQCPLCPKNFKKH-SLRAH 746
            ..:|..|...:...|         |...::.|:           |...||.||..|:.. .|..|
Human   917 YFEYYEDTGSNNFLHEIHDPQHLETADASLSKHSSVFHWTDLSLEKKSCPYCPATFETGVGLSNH 981

  Fly   747 LRNHTNEKIFECTECLQKFARRHNLKNHVIT-----KHAK-VGDKEKKKYAAKDVEQSK--PKYQ 803
            :|.|.:....       .:..||.:....|.     :|.| .|.....|...|.:|:|:  .::.
Human   982 VRGHLHRAGL-------SYEARHVVSPEQIATSDKMQHFKRTGTGTPVKRVRKAIEKSETTSEHT 1039

  Fly   804 CGTCGKLLAKKYSLKLHEISHSK 826
            |..||.....|..|..|...|.|
Human  1040 CQLCGGWFDTKIGLSNHVRGHLK 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	5/20 (25%)
		C2H2 Zn finger	731..750	CDD:275368	8/19 (42%)
		C2H2 Zn finger	758..779	CDD:275368	3/25 (12%)
		C2H2 Zn finger	804..824	CDD:275368	6/19 (32%)
		C2H2 Zn finger	834..856	CDD:275368
		C2H2 Zn finger	898..918	CDD:275368
		zf-H2C2_2	910..935	CDD:290200
		C2H2 Zn finger	926..945	CDD:275368
		C2H2 Zn finger	957..984	CDD:275368
ZNF644	XP_005271314.1	C2H2 Zn finger	412..432	CDD:275370	3/21 (14%)
		RNAP_largest_subunit_N	438..>501	CDD:302765	23/95 (24%)
		C2H2 Zn finger	450..470	CDD:275370	7/19 (37%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000