DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31612 and znf644a

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001265183.1	Gene:	znf644a / 100007441	ZFINID:	ZDB-GENE-030131-6244	Length:	1169	Species:	Danio rerio

Alignment Length:	1281	Identity:	237/1281 - (18%)
Similarity:	388/1281 - (30%)	Gaps:	497/1281 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DTHVSATLISS---SNLDHSYDGFHFTEPEAPSSYLRKTAASHGGKTSKSLTEAYDLPYELGADL 115
            :..:|.:.||.   ||...|.:|                  :..|.:...|.|..:|..:.| ||
Zfish    12 ENDISMSSISQDLLSNQSFSVEG------------------TTSGPSVHCLHETMELLSDQG-DL 57

  Fly   116 FFSSLQLQSVATGGKI--------------------------GSVPRQ---ERSKDESWSAPAGD 151
            ..|...:.|:.:.|..                          |.:|:.   :.|...:......|
Zfish    58 LSSVSFIDSICSDGPAKAAYVNGSTSPHISDEILLDISKNVPGFLPKSLHAQNSVTTNVHFEGAD 122

  Fly   152 PLLKAVRENDETVFKPL-----------HFDHEYPEAS-DEEDDE----------------DEHE 188
            ||.|   |.:.|:.:.|           .||:|.|||| |..||.                |:..
Zfish   123 PLRK---EGEITIRQTLTAEDVENRGIWGFDNESPEASLDNYDDANDLGWNPQREFMKFLWDDDN 184

  Fly   189 EFDAEEDEEEYDA-----RRHSPPIVPASHTGGKWKPEQRPQLRHPHIERLSPSWDEPPEENYTH 248
            ..|.||......:     ||...|||           .:|.:.:...:.::.|| ::|..:....
Zfish   185 GLDIEEKLSPVPSPINQKRRVPSPIV-----------HKRRRRKEKLVLKVDPS-EDPFSDLNLD 237

  Fly   249 PPADHTKGKWVPG-SKQLEY------RENLDLTKLDQPGASYWCNICCRRLKSRLYYNQHLRSGY 306
            ...||      || ...:|:      |.....:||..|           .:|:..|:|....:..
Zfish   238 SKQDH------PGEGSPIEFGPVKKTRSPRKPSKLQSP-----------IVKNTKYFNGTAEAVK 285

  Fly   307 HIKRAEAECEL---EQATLGRELTLSKDFS----IKDDADKNEPKPPKRQRRAN----------L 354
            |:....|:..|   ::..|.|| |||.|..    .:.:.|..|....:.|...|          .
Zfish   286 HLFPKPAKKPLSKTQKIGLIRE-TLSSDSEGPTFFQQNNDFKEKSLGQNQITCNKDTTSSKPFVC 349

  Fly   355 LRCDLCRHTMARHLIGKHLISHY-HFRRLQQQSRIRRQACLQEILKHMGSIVRQSPFQCMPCRFY 418
            ..|..|.:.  |..:..|:..|. ..::|.|..:|:.:.             :.:..||..|.|.
Zfish   350 KECGQCYYD--RSSLLNHISVHQDKGKKLNQFHQIKDEG-------------KDAKLQCPQCNFG 399

  Fly   419 ANTEETFLYHWKSHEHLELTKRLGGTFWCSFCQFNSNTNNSMLLHLLDSSHKEVLLALNRSVPIC 483
            .|...||:.|.|:||.   .||.   :.|:.|.|.....:.:..||.   ||..::..:.:|...
Zfish   400 TNCPNTFVQHAKTHEK---DKRY---YSCNKCDFVEMNEDDLRRHLY---HKHGVIGADHTVWKS 455

  Fly   484 IA-QRRRIQCSRCGMEF---------------LYNIQLRQHSITEHPGLALTGTAADE-----YQ 527
            .. |.|::..|.|...:               :...|:..||:          .:.||     .|
Zfish   456 DGFQERKVNKSPCLNSYSPSFERKTKNSVGNHVEEEQVNSHSL----------DSGDEEPPTTEQ 510

  Fly   528 SRFRCNLCGSSQKSRLALQR------HKKHKHHLARYFCAICRLE---FDNSLDARRHRSLVIHK 583
            |...||:..|..|.:....|      ....:::|:...|.:.|.:   .::.||...|..|...|
Zfish   511 SFSACNVLTSCAKPKARSPRLLVKFGAPDEENNLSNDKCGLLRKKKRVGESKLDKSIHTLLSRKK 575

  Fly   584 QKARPQTSIPQPENEIEHMLREVLEETV---------PSPPA---KRSA-------------DVN 623
            ::.:..:.|...:...:...:|.|:.::         .|||:   ||||             |||
Zfish   576 RRDKSGSEIDTHQEPAKSSTKEFLDRSLNCETTFSETSSPPSKYLKRSAHSKEGNTKRTSKFDVN 640

  Fly   624 AKCSN---------SRKTIESSQRLAQHQAEVHSSDNHLCL----SCGISFESAQALGRHTRSCQ 675
            ..||.         .::|::.|....:.....|:......|    .|...|:..||    ||..:
Zfish   641 VTCSEDAGKTHLGLEKQTLKKSPSKRKMSTPFHNMQGQDILLDFPKCRQKFKKPQA----TRRRK 701

  Fly   676 PLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRSGTIG---------------- 724
            .|.:.|   |:......:: ..::|.......:.||..|...::: ::|
Zfish   702 VLINNS---DILSVSSDAL-GPEECEMDKNANARLVKRRSSSSKA-SLGASASHFERNHSSPRVL 761

  Fly   725 ------KNEVLQ--------------------CPLCPKNFKKH-SLRAHLRNH------------ 750
                  |:|.:.                    ||.||..|:.. ||..|:|.|
Zfish   762 SVKDEYKDEEISESITAVKLEPSSDVETDLKGCPYCPAVFESGISLSNHIRGHLHRVGLKVRRAP 826

  Fly   751 -------TNEKI----------------------------------FECTECLQKFARRHNLKNH 774
                   .::|:                                  ..|..|.:.|..|..|.||
Zfish   827 VKSAVKVASDKVPPVRRQALSQVKTEEDTSQTDHPAELPTDCQQTELICPLCREWFDNRTGLSNH 891

  Fly   775 VITKHAKVG-------------------------------------------------------- 783
            |.....::|
Zfish   892 VRGHLKRLGKPTSTASKSPVIILKELMRDKKQFQLKLQVLEKKCRTTNTFYPVRLGNGLTFASTV 956

  Fly   784 -----DKEKKK-------YAAKDV----------EQSKPKYQCGTCGKLLA----KKYSLKLHEI 822
                 |||:||       ....|:          |::|.|:|..|..|.|:    |...|::|.
Zfish   957 KRQKDDKEEKKRLEINKGSPPSDLIGILKKRRAHEEAKAKHQSLTAKKALSLTSGKDCGLEIHT- 1020

  Fly   823 SHSKAV----------ERNYLCHFADCSYAGRTPESLKTHLVSHSQENHKCARINCSYVGKSELH 877
              .|||          :||...|   |:.:..:..||..||..:||...|..:...:
Zfish  1021 --CKAVPSSPGEKGDNKRNVCVH---CNASFHSGISLSNHLRGYSQRKRKALQDGAT-------- 1072

  Fly   878 LKRHLKSAHSTEKNGEEWFSCDQCDFRARIKGHLRRHSLRHSGQKPHQ--CPHCDF--------Q 932
                              ..|.|...|||.....:..||.|:.::.::  |..||.        |
Zfish  1073 ------------------LDCKQRKQRARPWSKKKAFSLMHNPEEIYRLTCRFCDLVFQGPLSVQ 1119

  Fly   933 CSTIDNLRKHIIKTG-KHPGMFIYHCAKCSDEEAGEIFKSNSYKEY 977
            ...|.:|::||:.|. .|.|             ||.:..::..|:|
Zfish  1120 EDWIKHLQRHIMNTAVPHTG-------------AGMVEVTSFPKDY 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	4/19 (21%)
		C2H2 Zn finger	731..750	CDD:275368	9/19 (47%)
		C2H2 Zn finger	758..779	CDD:275368	8/20 (40%)
		C2H2 Zn finger	804..824	CDD:275368	6/23 (26%)
		C2H2 Zn finger	834..856	CDD:275368	6/21 (29%)
		C2H2 Zn finger	898..918	CDD:275368	7/19 (37%)
		zf-H2C2_2	910..935	CDD:290200	7/34 (21%)
		C2H2 Zn finger	926..945	CDD:275368	8/26 (31%)
		C2H2 Zn finger	957..984	CDD:275368	4/21 (19%)
znf644a	NP_001265183.1	C2H2 Zn finger	349..369	CDD:275368	4/21 (19%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	422..439	CDD:275368	3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000