DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and pdzph1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_700271.6	Gene:	pdzph1 / 571576	ZFINID:	ZDB-GENE-090313-385	Length:	1215	Species:	Danio rerio

Alignment Length:	963	Identity:	166/963 - (17%)
Similarity:	290/963 - (30%)	Gaps:	346/963 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HQ--KRPSISNWFS-------------SLRRQPKNKKCSPGLGGSESVGRKQPLQRSC------- 47
            ||  |.|.|.:|..             |:........|:.....|.....:...::||
Zfish   194 HQNHKNPQIYSWTQHGAHYQQNVSYKISIAELNAESSCASKSQSSWDDPEEVACRKSCCKNNFHW 258

  Fly    48 ---LDLSTTRV-GCDGCVSL-EFFQSE-------SPESRR-------------SNSTFYVNTQNV 87
               .|...|.| |...|.|| :|:|.:       ||.:..             ::|...|..:||
Zfish   259 GGQTDTDFTLVDGSSRCSSLSDFWQRQKQPSLPTSPSNEALWDIPPPEQFADGNSSALDVLAENV 323

  Fly    88 SSA--------VFKDN-----------------RQPLLERGSG-------SDSSPSS---VCVRC 117
            :|.        :.:||                 ||..||..:.       |::||..   :..|.
Zfish   324 ASCQISPRENFINQDNINCTQTASEVPLCKEFIRQNTLEENNEPRYCEELSEASPHEHLFMSPRV 388

  Fly   118 SCN--SITKSGDRNETPTMATPKSDIKIA---------LKPPPKPRSPSMAPYTSVATYNITKLA 171
            |.|  |.||:...|.........:.|.|.         ::.|||.|.      |......:...|
Zfish   389 SINRSSFTKNFINNHERKTRLRNNSIAILETKTHPAGYMEIPPKRRK------TFPGVSYLMSQA 447

  Fly   172 PDSPPPASPTLSTQTVNCSDVTTKVTEVQRLPC-----------DE----PNTELISKRTEYKHT 221
            .||.|....:.|:.|::.       ..:|.|||           ||    ..:...|..:.|:.:
Zfish   448 RDSIPSYRESFSSGTLSS-------FFMQSLPCQAEKMGRFFAEDERLRPVGSRKSSSSSSYRPS 505

  Fly   222 TITTT---------------TRTLIVSRPVELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEIG 271
            :.:||               ......||.     :|:.|.:..|..:......|..|::...|..
Zfish   506 SSSTTGPDSFGPKCRAYSTIKNPFYPSRS-----DESPEEVFFRGEQYHEQEHLDEMVEPSLEAD 565

  Fly   272 TGGLFMEADPCS-----KNSLPPPPYIDDMRFIDDS---------------------SNSQSESE 310
            .|.:|.:.|..|     .|.:....:.::|..:|:|                     |.|.||.:
Zfish   566 VGMMFADLDSTSGGHTELNEVSESGFDEEMVELDESISAGNTMDSHQRELLIHVIPPSLSNSEEK 630

  Fly   311 RNSNIH---KTNKYTSKNNNNDSKRESQQSNLC-ESCRMLLDRNYI------------------- 352
            .|..||   |.|.:.........:|.|..:.:. ::.:..|..||:
Zfish   631 INEGIHYSLKPNTFEEDETEGLMRRASVMTIITGDNEQRFLQGNYVFSLDGEVSPDALSPVSESP 695

  Fly   353 ---------------------------------NTEQSDNLVI------LRRPSKQIKDELCE-- 376
                                             .:.||.|..:      :.|..|..|::|.|
Zfish   696 TGSPIEDLGSIREGVEELQDSSQAPKTTTVQMNMSSQSPNATLDKISRDVCRTPKVYKNDLSERP 760

  Fly   377 -----VVSEMEALDVPEDCKHSNKDKQMSIGRKK----------------------------FNM 408
                 .:...|.|..|.|..|.:.:.......|:                            .|.
Zfish   761 NASKNTLEVKEHLKPPTDSIHKDSEDHSDHWAKRRKLFKESKQRSSAGGNSISSNITEESDTMNS 825

  Fly   409 DPKKGIEYL---VENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAF---VALH 467
            :..:.::..   :|:|....:......::|.|..:.          :|| :...|::.   .|:.
Zfish   826 EDTRSVDMSMRDIEDRGFYTETFHSVSWIYHGAEVT----------QND-SPHCLRSCARPAAIR 879

  Fly   468 DFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTS 532
            :.| :.:.:.:.::.|.||:            .|::      |.:.|..||
Zfish   880 ERT-VKICKGVGEYPWGFRI------------QFSK------PIVVTEVDT-------------- 911

  Fly   533 LHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDK- 596
             :.|:.:....|..|:.    ..||.|:.........:..|..|..:....|:|:..|...|..
Zfish   912 -NGPAEEAGLQVGDFVQ----AVNGTDVTSVPHSEAADLARQGPDLLTLTIGSDIGRTPNTPRPA 971

  Fly   597 -EGWLWK--QGGRYKSWKRRWFIL-NDNCLYYFEYTTDK---EPRGIIPLENISVREIHDRSKPH 654
             .|:|.|  |....|.|::|||:| :|.||||:....|:   ....::.||...|.......||.
Zfish   972 CRGYLHKRTQSSFLKGWRKRWFVLRHDCCLYYYRNKRDEGKSRALSVMSLEGALVEADSTLGKPF 1036

  Fly   655 CFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSI 707
            .|......|                   :..|.:.|.:.::.:.|::.:.:::
Zfish  1037 VFRCCPVSG-------------------NRAYYLCATSNQEMKRWLEAMGRAV 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	26/213 (12%)
		PH_GRP1-like	592..710	CDD:269954	27/124 (22%)
		PH	596..708	CDD:278594	26/120 (22%)
pdzph1	XP_700271.6	PDZ_signaling	880..957	CDD:238492	17/114 (15%)
		PH-like	963..1069	CDD:302622	28/124 (23%)
		PH	972..1071	CDD:278594	26/118 (22%)
		PH	1102..1192	CDD:278594
		PH	1102..1192	CDD:214574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910