Protein Alignment step and PLEKHM3

DIOPT Version :9

• Sequence 1: NP_001036375.2
• Gene: step / 35425
• FlyBaseID: FBgn0086779
• Length: 727
• Species: Drosophila melanogaster
• Sequence 2: NP_001073944.1
• Gene: PLEKHM3 / 389072
• HGNCID: 34006
• Length: 761
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 114/577 - (19%)
• Similarity: 188/577 - (32%)
• Gaps: 236/577 - (40%)

  Fly   233 SRPVELLLNENGEI-IARRSPRKSRS--------------NSLGRMLDVQNEIG-TGGLFMEADP 281
            :|.|:.:|.:|.:: :...||.::..              ..:||    |||:. :.||....|.
Human   273 ARMVDTVLYDNTQLQLKAESPWEALDWGQKLWEVVHAAVPGYMGR----QNELTISPGLGHHDDY 333

  Fly   282 CSKNS--------LPPPPYIDDMRFIDDSSNSQSESERNSNIHKTN---KYTSKNN--------- 326
            ...:|        |||.|.:|             .|::..||.|:.   :.|.:||
Human   334 TQNHSFQKKTSGLLPPSPVLD-------------SSKQYQNILKSGTLYRLTVQNNWKAFTFVLS 385

  Fly   327 --------------------NNDSKRESQQSNL--CESCRMLLDRNYINTEQSDNLVILRRPSKQ 369
                                |.|.....|..||  |:||..::        ...:::.||..::|
Human   386 RAYLMAFQPGKLDEDPLLSYNVDVCLAVQMDNLDGCDSCFQVI--------FPQDVLRLRAETRQ 442

  Fly   370 IKDELCEVVSEMEALDVPED-CKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHF 433
            ...|.      ||||.:..: .:.|.::.|::                      ||:.|:|
Human   443 RAQEW------MEALKIAANVARSSEQNLQVT----------------------LRNKPKD---- 475

  Fly   434 LYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKID--- 495
                      .:|.:...||. .:.|..:|:::  .|.|.|.:.|.  ..||:..|..:.|.
Human   476 ----------QMGGHELRKNK-RQSVTTSFLSI--LTTLSLERGLT--AQSFKCAGCQRSIGLSN 525

  Fly   496 ---RMMETFAQRYCQLNPDIFTNTDTCYV-LSFAI---IMLN--TSLHNPSVKDKPTVDQFISMN 551
               ::.......||          .:|:| .||.|   |:.|  ||.:..|.:.|.
Human   526 GKAKVCNYSGWYYC----------SSCHVDDSFLIPARIVHNWDTSKYKVSKQAKE--------- 571

  Fly   552 RGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQGGRYKSWKRRWFI 616
                        .||.:||    ||....|.:...|.|   :.:....:.:...|.||.:...|
Human   572 ------------FLEYVYE----EPLIDIQQENAMLYH---HAEPLAAVLRLRQRLKSLRAYLF- 616

  Fly   617 LNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPHCFELFATGGADIIKACKTDSEGKVVEG 681
               :|.   ....:...|.|.|.|.: :::||         |::.  ||:         .:|:||
Human   617 ---SCR---AAVAEDLRRRIFPREYL-LQQIH---------LYSL--ADL---------QQVIEG 654

  Fly   682 K--------------HTVYRMSAATEEDQQEWIKRLTQSISHN-----PFYDILVQR 719
            |              | ||..|..::       |.....|.:|     ||.||...|
Human   655 KLAPFLGKVIKFATSH-VYSCSLCSQ-------KGFICEICNNGEILYPFEDISTSR 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	36/191 (19%)
		PH_GRP1-like	592..710	CDD:269954	24/131 (18%)
		PH	596..708	CDD:278594	23/125 (18%)
PLEKHM3	NP_001073944.1	PH_PLEKHM3_1	214..303	CDD:270193	6/29 (21%)
		PH	362..454	CDD:278594	21/105 (20%)
		PH_PLEKHM3_2	364..451	CDD:270136	18/100 (18%)
		zf-RING_9	529..729	CDD:290612	52/249 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910