DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	236	Identity:	56/236 - (23%)
Similarity:	85/236 - (36%)	Gaps:	84/236 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 INNG----GDLPRGLLESLYE---------SIRTEPFKIP--------------QDDGNDLM--- 588
            :|:|    .|||||..|...|         :.:|..|:.|              |::.|..|
Human    46 VNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQ 110

  Fly   589 -------------------------------------HTFFNPDK------------EGWLWKQ- 603
                                                 |:|...|:            .|||.||
Human   111 DRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQD 175

  Fly   604 GGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREI--HDR-SKPHCFELFATGGAD 665
            ....:.||||||:|.|.||:|::.:.::...|.|||.:..:..:  .|| |:.:.|:...||...
Human   176 SSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRA 240

  Fly   666 IIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQS 706
            :|....|........|..|.| .||.|:||...|::.:.|:
Human   241 LIYNSSTAGSQAEQSGMRTYY-FSADTQEDMNAWVRAMNQA 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	10/35 (29%)
		PH_GRP1-like	592..710	CDD:269954	39/131 (30%)
		PH	596..708	CDD:278594	38/127 (30%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827	8/28 (29%)
		PH_PEPP1_2_3	159..281	CDD:270068	38/123 (31%)
		NESP55	<299..460	CDD:115071
		DUF1640	779..905	CDD:311647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910