DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and AgaP_AGAP002729

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_312197.3	Gene:	AgaP_AGAP002729 / 1273239	VectorBaseID:	AGAP002729	Length:	948	Species:	Anopheles gambiae

Alignment Length:	504	Identity:	96/504 - (19%)
Similarity:	162/504 - (32%)	Gaps:	183/504 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 LRRPSKQIKD----ELCEVVSEME-----------------ALDVPEDCK--HSNKDKQMSIGRK 404
            |..||...:|    :|.::..|::                 |:..|.:.:  |...|:..:  .:
Mosquito    23 LGSPSTGSEDGGGIDLADIAQELDQDEFDGPATLNGAFDRPAITAPPESEWYHGRLDRYSA--EQ 85

  Fly   405 KFNMDPKKGIEYLVENRLLRHDPQDVAHFL-YKGE-GLNK---TAI-GD-YLGEKNDFN------ 456
            :.....|.| .|||.    ..|.:..::.| |.|. |:|.   ||: || |:|.:..|:
Mosquito    86 RLKSTTKLG-SYLVR----ESDRKPGSYVLSYLGRTGINHFRITAVCGDFYIGGRQFFSLSDLVG 145

  Fly   457 -----EDVL------------------KAFVALHDFTNLILVQALR---------------QFLW 483
                 .|:|                  |..||:..:|.:.....|.               .:||
Mosquito   146 YYTSCSDLLKRERLVQPVPPPEPVNDKKRVVAILPYTKMPDTDELTFQKGDIFFVHNDMGDGWLW 210

  Fly   484 -SFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNT------DTCYVLSFAIIML-----NTSLHNP 536
             :....||...|      |.:....|:|.|..||      .|| ..:.|:.||     .:.|..|
Mosquito   211 VTAHRTGEQGMI------FRELVEDLDPAIDPNTVFPWFHPTC-TKNEAVDMLVKAGPGSFLVRP 268

  Fly   537 SVKDKPTVDQFISMNRGINNGGDLPRGL-----------LESLYESIRTEPFKIPQDDGNDLMHT 590
            |.........|..:|..|.......:|:           |:::....|.|...    :|:.|||.
Mosquito   269 SDNSPGDYSLFFHINNQIQRFRIEKKGVRYLMGGRTFECLDAVINRYRKEQIV----EGHTLMHP 329

  Fly   591 FFNPDK-------------------------------------EGWLWKQGGRYKSWKRRWFIL- 617
            ..|..:                                     .|:|.|:..:...||:.:|.|
Mosquito   330 VINGSQPEYHPPTNLASAAEKIYATLRECRDQNMLKKTKGIKHHGYLLKKSDKTAKWKQLFFALL 394

  Fly   618 ---NDNCLYYFEYTTDKEPRGIIPLENISVREIHDR--SKPHCFELFATGGADIIKACKTDSEGK 677
               ::..|.:::.....:|:|:|.|....:.:.|:.  .:.|||::..                :
Mosquito   395 VEGSETHLCFYDSPKKTKPKGLIDLSCAYLYQCHESFWERQHCFQIVE----------------R 443

  Fly   678 VVEGKHTVYRMSAATEEDQQEWIKRLTQSISHNPFYDILVQRKKKALSK 726
            .:....|:..:.|..:|...|||..|.   ||      .|.:..||.||
Mosquito   444 ALPCLATITYLCANNQECYVEWISALK---SH------CVSQLSKAQSK 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	51/253 (20%)
		PH_GRP1-like	592..710	CDD:269954	25/160 (16%)
		PH	596..708	CDD:278594	23/154 (15%)
AgaP_AGAP002729	XP_312197.3	SH2	51..155	CDD:301589	23/110 (21%)
		SH3_RasGAP	172..230	CDD:212722	11/63 (17%)
		SH2_Cterm_RasGAP	241..315	CDD:198217	13/74 (18%)
		PH_RASA1	368..473	CDD:270080	25/129 (19%)
		PH	370..473	CDD:278594	25/127 (20%)
		C2_Ras_p21A1	488..611	CDD:176045
		RasGAP	594..947	CDD:214617
		RasGAP	609..948	CDD:295371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910