DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtp and dnajc7

DIOPT Version :9

Sequence 1:	NP_610075.2	Gene:	Mtp / 35362	FlyBaseID:	FBgn0266369	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_012827094.1	Gene:	dnajc7 / 448421	XenbaseID:	XB-GENE-946345	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	484	Identity:	93/484 - (19%)
Similarity:	169/484 - (34%)	Gaps:	158/484 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TLLLLALFLGLLED------------------GKTALIAPNS-------QQIFKLQ--NQVILQE 48
            ||::|:.:...|||                  ||..|...|:       |::.:|:  |:...:|
Frog    70 TLMMLSKYREALEDAQQSVRLDDAFVKGHQREGKCHLSLGNAMAATRCFQKVVELEPKNEQARKE 134

  Fly    49 LGRDSSSAETSYTFETDLKINSVWSGDEDQLLEVFISGSKVDASGKARSITRIPDRPFYISLVRG 113
            |...::..|.....|.|.:       ..|....||.....::.:........:  :...::|:..
Frog   135 LKNAAAVLEYERIAEADFE-------KRDFRKVVFCMDRSLELAPACHRFKIL--KAECLALLGR 190

  Fly   114 QPDKVIAHTSKDQSLLNLERGIASLLQLRLDASQEEELDVSGLC---------RVSYNV---KSS 166
            .||               .:.:||.: ||:||:..:.|.|.|||         .|.:.|   |.:
Frog   191 YPD---------------AQSVASDI-LRMDATNADALYVRGLCLYYEDCIEKAVQFFVQALKMA 239

  Fly   167 TKVEKTKRDCSLWDLRVNYNPEEALGVTQQAQETVF----YELSSEGTLLHAESQENHRLNLAAK 227
            ...:|.:..|         ...:||...::.....|    |:|:             |||...|.
Frog   240 PDHQKARLAC---------RNAKALKAKKEEGNQAFKDGNYDLA-------------HRLYSEAL 282

  Fly   228 PDVGSFVKSSLILQHVSQGSEEVKQLQLGSLDKAIQS-----------LLEWYRVFELESDVDGM 281
            ....:.:|::..| :.::|:...|   |..|::||:.           :..:.|..:..:|.:
Frog   283 CIDPNNIKTNAKL-YCNRGTVNAK---LKKLNEAIEDCTNAIKLDDTYIKAYLRRAQCYTDTE-- 341

  Fly   282 ISAIKEQTLEDQLKASLTELQSADVGKSSLALAYVKLIPLARITRQEQFEDLLTEHAEVLPQLVD 346
               :.|:.:.|..|...||  |....|..|..|.::   |.:..|::.::
Frog   342 ---LYEEAVRDYEKVYQTE--STKEHKQLLKNAQLE---LKKSKRKDYYK--------------- 383

  Fly   347 LLGAVQTFDAHNATFGFLYKESETTSEQLDLLEKYLQSLAVATHPDRKIVEHLFGLLE--QESIK 409
            :||.                 .:..||  |.::|..:..|:..||||    |.....|  :|..|
Frog   384 ILGV-----------------DKNASE--DEIKKAYRKRALMHHPDR----HSAATAEVQKEEEK 425

  Fly   410 KHLKLRE--SVIQTVATLTR-QSGLDVED 435
            |..::.|  :|:.......| .||.|:|:
Frog   426 KFKEVGEAFTVLSDAKKKARYDSGQDLEE 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtp	NP_610075.2	LPD_N	38..567	CDD:214755	82/432 (19%)
dnajc7	XP_012827094.1	TPR repeat	29..55	CDD:276809
		PEP_TPR_lipo	34..>335	CDD:274350	58/315 (18%)
		TPR repeat	60..90	CDD:276809	6/19 (32%)
		TPR repeat	95..123	CDD:276809	5/27 (19%)
		TPR repeat	144..169	CDD:276809	5/31 (16%)
		TPR repeat	174..204	CDD:276809	6/47 (13%)
		TPR repeat	209..237	CDD:276809	7/27 (26%)
		PLN03088	252..>352	CDD:215568	21/121 (17%)
		TPR repeat	256..283	CDD:276809	7/39 (18%)
		TPR repeat	288..322	CDD:276809	8/37 (22%)
		TPR repeat	327..355	CDD:276809	5/32 (16%)
		DnaJ_bact	380..>479	CDD:274090	23/113 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860