DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtp and LOC400499

DIOPT Version :9

Sequence 1:	NP_610075.2	Gene:	Mtp / 35362	FlyBaseID:	FBgn0266369	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001357633.1	Gene:	LOC400499 / 400499	-ID:	-	Length:	3320	Species:	Homo sapiens

Alignment Length:	937	Identity:	194/937 - (20%)
Similarity:	316/937 - (33%)	Gaps:	277/937 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 ISGSKVDASGKARSITRIPDR-PFYISLVRGQPDKVIAHTSKDQSLLNLERGIASLLQLRLDASQ 147
            |.|:||:...::.|::....| |....|..|:...:..|.::.:.:||::|.:.||||....|..
Human   103 ILGAKVELLKESESLSATLGRNPLRFILHSGRVAHLCPHPTEPRWVLNVKRAVLSLLQGHPGAHS 167

  Fly   148 E---EELDVSGLCRVSYNVKSSTKVEKTK--RDCSLWDLRVNYN----PEEALGVTQQ------- 196
            .   :|:|:.|.|..:|. .....:.|||  ..|||...|.:.:    |..|.|:|.:
Human   168 PKTFDEVDILGRCPTTYQ-HHGDWLHKTKDLARCSLRRGRSSLHSQALPGVAPGLTSRLTCVQSF 231

  Fly   197 ----AQETVFYELSSEGTLLHAESQENHRLNLAAKPDVGSFVK----SSLILQHVSQGSEEVKQL 253
                .:|....||.|.|.|                |...|.|:    |||.|.|      |:.|.
Human   232 RAGVLREASCTELDSAGPL----------------PAKASAVQMRTLSSLSLLH------EMPQD 274

  Fly   254 QLGS-------LDKAIQSLL-EWYRVFELESDVDGMISAIKEQTLEDQLKASLTELQSADVGKSS 310
            ..|:       .|....||| ||                  |:|....:.|:
Human   275 PAGTDPDDRDDEDMTPSSLLYEW------------------EETPSQAMVAT------------- 308

  Fly   311 LALAYVKLIPLARITRQEQFEDLLTEHAEVLPQLVDLLGA-------VQTFDAHN---------- 358
             |...|:.:.||:.|..|..:..||    ::.||..|.|.       ..:|...:
Human   309 -AATLVRRLCLAQTTSLEAMDLFLT----LVSQLQGLSGGELMELWQYSSFKCRDNGQPLLDALP 368

  Fly   359 -----ATFGFLYKESETTSEQLDLLEKYLQSLAVATHPDRKIVEHLFGLLE--QESIKKHLKLRE 416
                 ...|.:.:...:.:.:.|.:|.:|.|||....|...:|..|..||:  :.|....|.:..
Human   369 SCGTEHCVGLMKELIASAAVEADEVEAWLSSLAFLPQPTDAMVHMLLPLLQTPRASPGAFLGISA 433

  Fly   417 SVIQTVATLTRQSG-LDVEDPLLKEVRSYLLQGLTSKEPT------LYIRALQNLQDPA-----T 469
            .|....|:|....| |.....|::.:...|.:..|.:||:      |.::|:.|....|     |
Human   434 LVHNLCASLDGPCGQLPGVGSLVRILGDALGENCTIQEPSDDDKLQLVLKAVGNAGLAAMALTPT 498

  Fly   470 IEALLEHAQTGEAPNLSVAALQALKAFPLGSFNSSHRLQFESIFYQRKRRFDSSARTLAL----- 529
            :.|..  :.....|.:.:.|:||.:..|..:..|.....::|:....:.|.::   .|||
Human   499 LSACA--SLRSSTPEIRLGAIQAFRRVPCSADRSVLSRLYQSLEEDAEIRINA---YLALMRCPS 558

  Fly   530 -DIILSLRPTQ-----EQLGNFLDYLASNDRQFEIKTYVLQKLRMLAEKCPRFRAL--------- 579
             ::...:|.||     .|:|:|            :.:::||   :|....|..|||
Human   559 EEVFAQVRRTQAGELSTQVGSF------------VWSHILQ---LLETHDPLKRALRDTLPEDIL 608

  Fly   580 ---FKSELVKRRHVNNY---NVLGQKGLTTVLTRQLSQAPAFNETLLSTQEVYQGILKRGSVEFL 638
               |..|:.|....::.   :|.|..|..  |...|..:||  ..|..:..|...|...|....|
Human   609 SQEFHPEMWKHSSYSDVTFRSVSGSLGAN--LEGTLLFSPA--SFLPRSATVNLTIHTMGRAFNL 669

  Fly   639 LHAGRSQASSFKLGIYTAGLGSLVGDGDSGD-----------GNDAIPADDEFSED--------- 683
            |..|....::.::.....|..|..|..|..:           |....||..|...|
Human   670 LELGLRLENAEEIAHRLFGRKSFWGQEDGREPEPEEPPGPEPGPAPQPASPECPGDRDRRMRYLQ 734

  Fly   684 ----------EAVTAGMEISVQGAQLR--------------PL-------VFFSGQTELMGHVWG 717
                      :|:...:.:.:.|.:|.              ||       ....||...|.....
Human   735 QKVTRRRGARQALRCELSVKLLGQELSFVNCGATGSHVNHWPLNLAELAIKLMKGQEVQMNRRLS 799

  Fly   718 GSASD-------STPAYQATTLSQDNEHYIILTSGATLHWRVLGARSVDLNGKVGFSL---WNRN 772
            .:|.:       ..||            .:.|.:.|.:..||.|  :.|...:..||:   ...:
Human   800 LAAQELVFPTVSGLPA------------RLTLNASAAISIRVRG--TTDFQQRSDFSVNGYVKPS 850

  Fly   773 AQTEIQQNTGSA-VLGHLAVGFTYAKLVQDFSITHEPKLSLNADLDFYSGIKLCMQLQRPEQ--- 833
            |..:|....|:| :||.  .|..:...|:..:       ||:..:....|..|.:.|..||:
Human   851 ALLQISAQMGTAGILGQ--AGLRWVTSVRSAA-------SLDGGIQVQKGRVLKVHLNTPEEAVE 906

  Fly   834 ---------LLKQTNVRSVFLQSVDRP 851
                     |:.:..|||  |:.|..|
Human   907 LLSFSSQLYLITRDGVRS--LRHVPGP 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtp	NP_610075.2	LPD_N	38..567	CDD:214755	122/562 (22%)
LOC400499	NP_001357633.1	Vitellogenin_N	50..585	CDD:331790	120/557 (22%)
		DUF1943	618..910	CDD:337318	58/318 (18%)
		C8	3262..>3308	CDD:337178
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910