Protein Alignment dia and AT2G25050

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001318287.1
• Gene: AT2G25050 / 817043
• AraportID: AT2G25050
• Length: 1168
• Species: Arabidopsis thaliana
• Alignment Length: 1228
• Identity: 264/1228 - (21%)
• Similarity: 449/1228 - (36%)
• Gaps: 365/1228 - (29%)

  Fly    60 EDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSR 124
            ||:..|:.:: :::|..:|                       .....::::.:..:|..|..:..
plant    38 EDYRVYVSRI-MSQLREQF-----------------------PGASFMVFNFRDGDSRSRMESVL 78

  Fly   125 FEKPIDYVEYLQNGE-------HSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGTIEKLLAR- 181
            .|..:..::|.::.|       .:.|...:..||..:....|.:....|.|  |..|:..:||.
plant    79 TEYDMTIMDYPRHYEGCPLLTMETVHHFLKSAESWLLLSQQNILLSHCELG--GWPTLAFMLASL 141

  Fly   182 -------SKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQ----SLDPRKPQT 235
                   |..:.:.|.|..:|.|.|..:|:   .||.:  |.|...:..:::    |..|...|.
plant   142 LLYRKQFSGEHRTLEMIYKQAPRELLQLMS---PLNPL--PSQLRFLQYISRRNVGSQWPPLDQA 201

  Fly   236 M---CEALKLLASFCIVYERNGYEKVLRAITTI-AATSFKASERFRPIVDALFASDQQDPKR--- 293
            :   |..|:|:..|      :| |...|.|..| ....|.||:|...::.::       |||
plant   202 LTLDCVNLRLIPDF------DG-EGGCRPIFRIYGQDPFMASDRTSKVLFSM-------PKRSKA 252

  Fly   294 --------------DLACHSL--IFINTLTNTPTDLN-----FRL-----HLRCEIMRMG----- 327
                          |:.||.|  :.:..:| ..:||.     ||:     .||..|:.:.
plant   253 VRQYKQADCELVKIDINCHILGDVVLECIT-LGSDLEREEMMFRVVFNTAFLRSNILTLNRGEID 316

  Fly   328 -LYDRLDEFTKIVEASNNENLQQHFKIFNE--------------IREDD------FEEFVQRFDN 371
             |::..|.|.|...|.         .||:|              :.|.|      |.:..:.|..
plant   317 VLWNTTDRFPKDFSAE---------VIFSEMGAGKKLASVDLPHMEEKDVLPMEAFAKVQEIFSE 372

  Fly   372 VTF---NMDDATDCFDVL-------KNLVTDTTSEPYFLSILQHL---------LYIRDDFYFRP 417
            ..:   |.|.|...|:.:       ::|.:.:...|...|:|:..         |.|.::....|
plant   373 AEWLDPNSDVAVTVFNQITAANILQESLDSGSPRSPDSRSLLESALEKVKEKTKLMISENIVSSP 437

  Fly   418 --AYYQLIEECISQIVFHKGYCDPNF------ENRNFNID------------------------- 449
              :..:..::.:|.   ||.|.|||.      |:|...:.
plant   438 DTSSPEKEKDTMSS---HKSYADPNSILKKVDESRGLRVSVQRNVHSKIFSPRMVQSPVTSPLPN 499

  Fly   450 -----------------------TSLLLDDIVEKAKAKESKRSEEYEKKIEQLES----AKQEAE 487
                                   ||:|.|.  ...|.:||..|......|..|.:    ...:.:
plant   500 RSPTQGSPASISRFHSSPSSLGITSILHDH--GSCKDEESTSSSPASPSISFLPTLHPLTSSQPK 562

  Fly   488 AKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPP---------PPPGGGGAPPPPPP------- 536
            ..:....:....:.:||   |...:....:.|:||         |||     ||||||
plant   563 KASPQCPQSPTPVHSNG---PPSAEAAVTSSPLPPLKPLRILSRPPP-----PPPPPPISSLRST 619

  Fly   537 PMPGRAG------GGPPPPPPPPMPGRAG--------------------GPPPPPPPP-----GM 570
            |.|....      |.||||||||:.....                    .||||||||     .|
plant   620 PSPSSTSNSIATQGPPPPPPPPPLQSHRSALSSSPLPPPLPPKKLLATTNPPPPPPPPLHSNSRM 684

  Fly   571 GGP-----------PPPPMPG-MMRPGGGPPPPPMMMGPMVPVLPHGLKPK---KKWDVKNPMKR 620
            |.|           ||||.|. :.|...|..||       ||..|.|||.:   :....:...::
plant   685 GAPTSSLVLKSPPVPPPPAPAPLSRSHNGNIPP-------VPGPPLGLKGRGILQNLKGQGQTRK 742

  Fly   621 ANWKAIVPAKMS---DKAFWVKCQ---EDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTK 679
            ||.|.....|::   ..:.|.:.|   |...|.|..::||...||:..:..:.::...|.....:
plant   743 ANLKPYHWLKLTRAVQGSLWAEAQKSDEAATAPDFDISELEKLFSAVNLSSDSENNGGKSGRRAR 807

  Fly   680 KNVD-LRVLDSKTAQNLAIMLGGSLKHLSYEQIKICL-------LRCDTDILSSNILQQLIQYLP 736
            ..|: :::::.:.|.|..|||         .::||.|       |..|..::..:.:..||::.|
plant   808 PKVEKVQLIELRRAYNCEIML---------SKVKIPLPDLMSSVLALDESVIDVDQVDNLIKFCP 863

  Fly   737 PPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAAC 801
            ..|..:.|:......|.|...|||...:.::.|:..:|...:||:.:...|.|::..:....:|.
plant   864 TKEEAELLKGFTGNKETLGRCEQFFLELLKVPRVETKLRVFSFKIQFHSQVTDLRRGLNTIHSAA 928

  Fly   802 EEIRNSKKFSKILELILLLGNYMNSGSKNE------------------------AAFGFEISYLT 842
            .|:|.|.|..:|::.||.|||.:|.|:..|                        :|.||.:..|.
plant   929 NEVRGSAKLKRIMQTILSLGNALNHGTARETLVLFKNLNSLLHFFLYISSLLTGSAIGFRLDSLL 993

  Fly   843 KLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRV-------NMDAIQKAMRQMN 900
            ||::|:..::|.||:|||..::.:|.|:.|||..||..:..|:::       .|.||.|.:.::.
plant   994 KLTDTRSRNSKMTLMHYLCKVLAEKLPELLNFPKDLVSLEAATKIQLKYLAEEMQAISKGLEKVV 1058

  Fly   901 SAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSK 965
            ......|||.|.:|       .|...:.:|......:|..|..:...:......|:.|:..||::
plant  1059 QEFTASETDGQISK-------HFRMNLKEFLSVAEGEVRSLASLYSTVGGSADALALYFGEDPAR 1116

  Fly   966 YTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAV 1023
            ...|:..:.::.|...|..:|.:|.: :.|.||||         |:::.|.::.||.|
plant  1117 VPFEQVVSTLQNFVRIFVRSHEENCK-QVEFEKKR---------AQKEAENEKLKKGV 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	35/203 (17%)
		Drf_FH3	253..453	CDD:461885	58/330 (18%)
		FH2	608..983	CDD:396655	95/422 (23%)
AT2G25050	NP_001318287.1	PTP_DSP_cys	16..189	CDD:475123	31/181 (17%)
		PTEN_C2	197..337	CDD:463081	36/163 (22%)
		FH2	745..1133	CDD:396655	93/403 (23%)