Protein Alignment dia and FMNL1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001398057.1
• Gene: FMNL1 / 752
• HGNCID: 1212
• Length: 1104
• Species: Homo sapiens
• Alignment Length: 1163
• Identity: 279/1163 - (23%)
• Similarity: 477/1163 - (41%)
• Gaps: 269/1163 - (23%)

  Fly    70 SVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDY 131
            :..||:.:|...:..||:|.||.:.|.....|::.::|            ....||:   .|..|
Human    31 AAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELI------------CDQERFQVKNPPAAY 83

  Fly   132 VE----YLQNG--------------------EHSTHKVYQCVESLRVALTSNPISWIKEF---GV 169
            ::    |:..|                    :.||    |.:..|..:|.:|.|.|::||   ..
Human    84 IQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQEST----QVLRELETSLRTNHIGWVQEFLNEEN 144

  Fly   170 AGIGTIEKLLARSKNNASYEKIEFE---------------------------------------- 194
            .|:..:.:.||.::.:.:|:....:
Human   145 RGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPA 209

  Fly   195 --------------------AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEA 239
                                .|.||:||||...|.::|:|  ..:.|..:|.||:.:.|:|....
Human   210 HSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMN--HPACVNEIALSLNNKNPRTKALV 272

  Fly   240 LKLLASFCIVYERNGYEKVLRAITTIAATSFK----ASERFRPIVDALFASDQQDPKRDLACHSL 300
            |:|||:.|:|  |.|::.:|.|.     .:||    ...||..::: .|.::..:....:||  :
Human   273 LELLAAVCLV--RGGHDIILAAF-----DNFKEVCGEQHRFEKLME-YFRNEDSNIDFMVAC--M 327

  Fly   301 IFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEF 365
            .|||.:.::..::|||:.|:.|...:|    ||.:.:.:..:.::.||...:.:
Human   328 QFINIVVHSVENMNFRVFLQYEFTHLG----LDLYLERLRLTESDKLQVQIQAY----------- 377

  Fly   366 VQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIE-ECISQ 429
               .||:          ||| ..|:.||.::.   ::|:|:..:::.........:..| |.:::
Human   378 ---LDNI----------FDV-GALLEDTETKN---AVLEHMEELQEQVALLTERLRDAENESMAK 425

  Fly   430 IVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLE 494
            |    ...:.........::|  |.:...|......|:|..|.||......:.....|.|...||
Human   426 I----AELEKQLSQARKELET--LRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALELKVEELE 484

  Fly   495 EK--VKLMEANG-----------VAAPSPNKLPKVNIPMPPPPPG-------GGGAPPPPPPPMP 539
            ||  ::::...|           ||.||....|...:|...|.|.       ..||.||||||:|
Human   485 EKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLP 549

  Fly   540 GRAG----------------GGPPPPPPPPMPG-RAGGPPPPPPPPGMGGPPPPPMPGMMRPGGG 587
            |...                |.|.|||.||:|| ....|||||||||..||.|||.|....|.||
Human   550 GLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGG 614

  Fly   588 PPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLA 652
            ||.   .:|.....|..|:|.||....|..|...||.|:.|::::...| .:..::|:.|:..::
Human   615 PPD---ALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVF-TELNDEKVLQELDMS 675

  Fly   653 ELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKI 713
            :...:|.:    |.|..::|    |.....|......::::..|:||||.|...  :|..|:|..
Human   676 DFEEQFKT----KSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKG--NLGAERICQ 734

  Fly   714 CLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIKRLSPRLH 775
            .:...|...|..:.|:.|:::||.......:...:.:..|:..:   ::|......|.||..|:.
Human   735 AIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMT 799

  Fly   776 NLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISY 840
            .|.|...:.|..|.:.|.:.|..||...|::|.|..:|||::|..|||||| ||..||:||.:..
Human   800 TLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNS-SKRGAAYGFRLQS 863

  Fly   841 LTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKN 905
            |..|...|..|.||||||||..::.:|:|....|:.||..::||..|::|::...:|.:...:
Human   864 LDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGL-- 926

  Fly   906 LETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEE 970
               :|...:..:.||   ..|:.:|.......:|.|.......::.::.:.||:..:|...:...
Human   927 ---ELTQREFVRQDD---CMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGL 985

  Fly   971 FFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQS--------------AR--------EQ 1013
            ||:....|..|::.|..:    .|:.:|:...|||...:              ||        |.
Human   986 FFSLFSRFIKAYKKAEQE----VEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISEL 1046

  Fly  1014 QERQQRKKAVVDMDAPQTQEGVMDSLLEALQ--------TGSAFGQRNRQARRQRPAG 1063
            :.|||::..:.:.|    ::|.::.::..|:        ||       |::.|:||.|
Human  1047 KRRQQKEPLIYESD----RDGAIEDIITDLRNQPYIRADTG-------RRSARRRPPG 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	51/267 (19%)
		Drf_FH3	253..453	CDD:461885	37/204 (18%)
		FH2	608..983	CDD:396655	101/381 (27%)
FMNL1	NP_001398057.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		279/1163 (24%)
		Drf_GBD	34..281	CDD:461886	51/264 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..200		0/32 (0%)
		Drf_FH3	284..>433	CDD:461885	36/192 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..474		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..635		50/127 (39%)
		FH2	633..998	CDD:396655	101/380 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1008..1037		5/28 (18%)