Protein Alignment dia and Fmnl1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001390541.1
• Gene: Fmnl1 / 57778
• MGIID: 1888994
• Length: 1113
• Species: Mus musculus
• Alignment Length: 1197
• Identity: 286/1197 - (23%)
• Similarity: 476/1197 - (39%)
• Gaps: 328/1197 - (27%)

  Fly    70 SVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDY 131
            :..||:.:|..::..||:|.||.:.|.....|::.::|            ....||:   .|..|
Mouse    31 AAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELI------------CDQERFQVKNPPAAY 83

  Fly   132 VE----YLQNG--------------------EHSTHKVYQCVESLRVALTSNPISWIKEF---GV 169
            ::    ||..|                    :.||    |.:..|..:|.:|.|.|::||   ..
Mouse    84 IQKLKSYLDTGGVSRKVASDWMSNLGFKRRVQEST----QVLRELETSLRTNHIGWVQEFLNEEN 144

  Fly   170 AGIGTIEKLLARSKNNASYEKIEFEA--------------------------------------- 195
            .|:..:.:.||.::.:.:|:....::
Mouse   145 RGLDVLLEYLAFAQCSVAYDMESTDSVASGAEKSKPLDQSVEDLSKAPPSSVPKSRLTIKCPPSP 209

  Fly   196 ---------------------------------------IRCLKAIMNNTWGLNVVLNPDQHSVV 221
                                                   |.||:||||...|.::|:|  ..:.|
Mouse   210 RYVHRHLGAGACWGLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMN--HPACV 272

  Fly   222 LLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK----ASERFRPIVDA 282
            ..:|.||:.:.|:|....|:|||:.|:|  |.|::.:|.|.     .:||    ...||..:::.
Mouse   273 NEIALSLNNKSPRTKALVLELLAAVCLV--RGGHDIILAAF-----DNFKEVCGEQHRFEKLMEY 330

  Fly   283 LFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENL 347
            .   ..:|...|.....:.|||.:.::..::|||:.|:.|...:|    ||.:.:.:..:.::.|
Mouse   331 F---RHEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLG----LDLYLERLRLTESDKL 388

  Fly   348 QQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHL------ 406
            |...:.:              .|||          ||| ..|:.:|.::.   ::|:|:
Mouse   389 QVQIQAY--------------LDNV----------FDV-GTLLEETETKN---AVLEHMEELQEQ 425

  Fly   407 -----LYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKES 466
                 ..:||......|....:|:.:||.                ..:...|.:...|......|
Mouse   426 VATLTERLRDTENDSMAKIAELEKQLSQA----------------RKELETLRERFSESTPMGTS 474

  Fly   467 KRSEEYEKKIEQLESAKQEAEAKAAHLEEK--VKLMEANG-----------VAAPSPN--KLPKV 516
            :|..|.||............|.|...||||  ::::...|           .|.||.:  :.|:|
Mouse   475 RRIPEPEKVPVPTVVRPSALELKVEELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAQAPRV 539

  Fly   517 NIPMP-----------PPPPGGGGAPPPPPPPMPGRAG------GGPP----------PPPPPPM 554
            :...|           ||||     |||||||:|....      ..||          |||.||:
Mouse   540 STDSPSTAESIPEAASPPPP-----PPPPPPPLPNLQSQQEAPPSAPPLAPPLPGCAEPPPAPPL 599

  Fly   555 PGRAGGPPPPPPPP-GMGGPPPPPMPGMMRPGGGPPP--PPMMMGPMVPVLPHGLKPKKKWDVKN 616
            ||..  |||||||| |..||.|||.|        |||  ||.::|...|.:..|:|.||....|.
Mouse   600 PGDL--PPPPPPPPLGTDGPVPPPPP--------PPPGGPPDILGGQGPDIGPGVKAKKPIQTKF 654

  Fly   617 PMKRANWKAIVPAKMSDKAFWVKCQEDKLAQD----DFLAELAVK-------FSSKPVKKEQKDA 670
            .|...||.|:.|::::...| .:..::|:.|:    ||......|       .|:...|..||
Mouse   655 RMPLLNWVALKPSQITGTVF-TELNDEKVLQELDMNDFEEHFKTKSQGPCLDISALKGKASQK-- 716

  Fly   671 VDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYL 735
              .||    |.:   ::::..|:||||.|...  :|..::|...:...|...||.:.|:.|.::|
Mouse   717 --APT----KTI---LIEANRAKNLAITLRKG--NLGADRICQAIETYDLQTLSLDFLELLTRFL 770

  Fly   736 PPPEH---LKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAG 797
            |....   :.|.::.:...|.|...::|......|:||..|::.|.|...:.|..|.:.|.:.|.
Mouse   771 PTDYERSLIARFEKEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAI 835

  Fly   798 TAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLAD 862
            .||...|::|.|..:|||::|..|||||| ||..||:||.:..|..|...|..|.||||||||..
Mouse   836 IAASMSIKSSDKLRQILEIVLAFGNYMNS-SKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVK 899

  Fly   863 LVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVM 927
            ::.:|:|....|:.||..::||..|::|::...:|.:...:     :|...:..:.||   ..|:
Mouse   900 VIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGL-----ELTQREFVRQDD---CLVL 956

  Fly   928 GKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHND---- 988
            .:|.......:|.|.......::.|:.:.||:..:|...:...||:....|..|::.|..:
Mouse   957 KEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKAEQEVEQW 1021

  Fly   989 ------NVRVREELEKKRRLQEAREQS---AREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQ 1044
                  :...|||....:...:||.|.   ..|.:.:||::..:.:.|    ::|.::.::..|:
Mouse  1022 KKEAAADTSGREEPPTPKSPPKARRQQMDLISELKRKQQKEPLIYESD----RDGAIEDIITDLR 1082

  Fly  1045 --------TGSAFGQRNRQARRQRPAG 1063
                    ||       |::.|:||.|
Mouse  1083 NQPYIRADTG-------RRSARRRPPG 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	52/285 (18%)
		Drf_FH3	253..453	CDD:461885	38/214 (18%)
		FH2	608..983	CDD:396655	108/388 (28%)
Fmnl1	NP_001390541.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Drf_GBD	28..299	CDD:461886	52/285 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..199		0/25 (0%)
		Drf_FH3	302..>451	CDD:461885	36/188 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..646		50/134 (37%)
		FH2	647..1012	CDD:396655	108/387 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1021..1113		19/93 (20%)