Protein Alignment dia and fhdc2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_009306082.1
• Gene: fhdc2 / 569206
• ZFINID: ZDB-GENE-091118-76
• Length: 916
• Species: Danio rerio
• Alignment Length: 597
• Identity: 146/597 - (24%)
• Similarity: 234/597 - (39%)
• Gaps: 143/597 - (23%)

  Fly   546 PPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKK 610
            |.||.|||       ||||||||   .|||....|:.|...|.
Zfish     7 PSPPIPPP-------PPPPPPPP---LPPPASASGLTRVDSGR---------------------- 39

  Fly   611 KWDVKNPMKRANWKAIVPAKMSDK-AFWVKCQEDKLAQDDFLAELAVKFSS-----------KP- 662
                |:.::..||:.|...::..: ..|    ...|.:|   :||.:..:|           ||
Zfish    40 ----KHRLRNLNWERIPKERIEGRNNVW----SGSLDED---SELTIDLNSLDELFGQKEGKKPE 93

  Fly   663 -----------VKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLL 716
                       .:..|:.::||.|          :||||.:.|:.|.|         .|:||..:
Zfish    94 RANGFRRSLLRCRSPQEISMDKVT----------LLDSKRSMNVGIFL---------RQLKIAAI 139

  Fly   717 RCDTDI-------LSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRL 774
            ....|:       ..:..|.:|.:.||..|...|:::.......|...:.|...:.||.
Zfish   140 EMVEDVRRGAAERYGAEKLAELCKLLPDNEEEARVKKFNGDRSLLAEPDLFILLLVEIP------ 198

  Fly   775 HNLNFKLTYADMVQDIKPDI----VAGTA---ACEEIRNSKKFSKILELILLLGNYMNSGSKNEA 832
             :...:|....:.|:..|.:    ||...   |..|:.:..:...||.|:|..|||||:|.....
Zfish   199 -SFRMRLDVMILQQEFDPAVTSLCVAARCLREAARELLSCPELHYILRLVLKAGNYMNAGGYAGN 262

  Fly   833 AFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMR 897
            |.||.||.|.||::||.......|||::|..|.||..|.|.|...||||:.|||::.:::.:...
Zfish   263 AAGFRISSLLKLADTKANKPGMNLLHFVAMEVVKKDKDLLMFSSRLSHVSPASRLSEESVVEDFS 327

  Fly   898 QMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKD---LSEYY 959
            ::.|.|.:|....|       .|.:..:....|.::...:   |.:.|.::|.|.:.   |.|::
Zfish   328 RLQSRVADLRVRAQ-------ADAEIEQQTRTFLQDAEVR---LKEAQNELESLQQSSEALVEFF 382

  Fly   960 AFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVV 1024
            ..|...:.:||.......|...||.|..:|  ...||:::||:  |||   ||..|:::......
Zfish   383 CEDDKTFKLEEACHIFHCFCHRFQRAVQEN--TERELQEQRRV--ARE---RENVEKRRSLALCT 440

  Fly  1025 DMDAPQTQEGVMDSLLEALQ-TGSAFG------------QRNRQARRQRPAGAERRAQLSRSRSR 1076
            .::|.:..:.:..:|..:|. |||...            :||.::..|.|   :....|.||...
Zfish   441 GLEAERDSDDLEHALQRSLSYTGSRRSLRRLSQYFQRSEERNLKSDSQHP---DSNLHLERSSRD 502

  Fly  1077 TRVTNGQLMTRE 1088
            :.:....|...|
Zfish   503 SELKRHSLQKNE 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886
		Drf_FH3	253..453	CDD:461885
		FH2	608..983	CDD:396655	97/415 (23%)
fhdc2	XP_009306082.1	FH2	40..406	CDD:396655	97/408 (24%)
		Smc	<316..>522	CDD:440809	46/219 (21%)