Protein Alignment dia and grid2ipb

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_068080705.2
• Gene: grid2ipb / 559717
• ZFINID: ZDB-GENE-040724-161
• Length: 1414
• Species: Danio rerio
• Alignment Length: 680
• Identity: 172/680 - (25%)
• Similarity: 264/680 - (38%)
• Gaps: 187/680 - (27%)

  Fly   449 DTSLLLD----------DIVEKAKAKESKRSEEYEKKIEQLESAKQEA-----EAKAAHLEEKVK 498
            ||...||          :||:..|..|:    :||:...|.|   ||.     |..:|..|:...
Zfish   758 DTDKFLDALSEQLGHRVNIVDDFKGGEN----DYEEMSFQDE---QEVNMLPHELSSASSEDHSS 815

  Fly   499 LMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPM------------PGRAGGGPP---- 547
            ..::..|:..|.:.      .:||||.    :|||||||:            |......||
Zfish   816 SDDSTSVSYSSGSD------HIPPPPQ----SPPPPPPPLQFTDSPSPLPITPEHLPQPPPAFQH 870

  Fly   548 -----PPPPPPMPGRAGGP-----------------------PPP-------------------- 564
                 ||||||.|..|..|                       |.|
Zfish   871 HPIIAPPPPPPRPFLANRPSLHKVLPTREELRAQHSHPRRSSPQPSSQPILQLHQPKAHPILQSS 935

  Fly   565 ----PPPPGMGG----------------------------------------------------P 573
                |.||....                                                    |
Zfish   936 PHTSPQPPHTSAQHTRLQHPSQSIYQSQQTTVPRTSPSLTKQKSLHSQPSQQSFEGTLSSKVPPP 1000

  Fly   574 PPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPM--KRANWKAIVPAKMSDKAF 636
            ||||:|    |...|||.|              ||..|....|.|  ||..|:.:   :.|:...
Zfish  1001 PPPPLP----PPCDPPPLP--------------KPSPKASDNNHMSVKRLRWEQV---ENSEGTI 1044

  Fly   637 WVKCQED----KLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAI 697
            |.:..:|    ||:......:|.:.|.::.......:....|..|.||:| :.:|..|.|.|.:|
Zfish  1045 WGQLGDDPDYHKLSDMVKYLDLDLYFGTQRNSISLPEPTFLPENLKKKDV-VEILSHKKAYNASI 1108

  Fly   698 MLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAA 762
            :: ..|| |:.::::..|:...|:.|....::||:.|.|..|.:|:.|........|...:||..
Zfish  1109 LI-AHLK-LAPKELRDILMTMSTERLEPAHIKQLLLYAPDDEEVKQFQHYDQDPAKLSEPDQFVL 1171

  Fly   763 TIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSG 827
            .:..:.....||.:|.||.|..:..::::........|..|::|||:.:||||.:|.:|||:|:|
Zfish  1172 QMLLVPEYKTRLRSLLFKTTVQEKTEEMRAAYECIYKASLELKNSKRLAKILEFVLAMGNYLNNG 1236

  Fly   828 S-KNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDA 891
            . |.....||:|::||:|:.||..|.|.|.||.||..:.:.||:.|.|..||..|..|::||...
Zfish  1237 QPKTNKTTGFKINFLTELNTTKTVDGKSTFLHILAKSLCQHFPELLGFSRDLITVPLAAKVNQRT 1301

  Fly   892 IQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQ-MEKLYKDL 955
            |...:..::|.::::.|...  |:|...:|:|:.||..|.|.|...|..|..:|.: |::.:| :
Zfish  1302 ITADLSDVHSTIQDIRTACV--KIPATAEDRFAAVMSSFLENCHPAVQSLDSLQQRAMDEFHK-V 1363

  Fly   956 SEYYAFDPSKYTMEEFFADIKTFKDAFQAA 985
            :.|:..|....|.|.||.....|...|:.|
Zfish  1364 ASYFGEDSKVTTTETFFGIFAEFISKFERA 1393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886
		Drf_FH3	253..453	CDD:461885	2/3 (67%)
		FH2	608..983	CDD:396655	111/382 (29%)
grid2ipb	XP_068080705.2	None