DRSC/TRiP Functional Genomics Resources

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Protein Alignment dia and GRID2IP

DIOPT Version :10

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:486 Identity:144/486 - (29%)
Similarity:225/486 - (46%) Gaps:58/486 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   520 MPPPPPGGGGAPPPPPPPMP----------GRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPP 574
            :||||     ..||||||:|          .....||......|:. :...|.||||||    |.
Human   749 IPPPP-----LSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLT-QLSHPVPPPPPP----PL 803

  Fly   575 PPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVK 639
            |||:         |..|||        |..||..::.......:||..|:.:   :.|:...|.:
Human   804 PPPV---------PCAPPM--------LSRGLGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQ 848

  Fly   640 CQE----DKLAQDDFLAELAVKF-SSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIML 699
            ..|    |||:......:|.:.| :.||.|     .|..|....||.| :.:|..|.|.|.:|:|
Human   849 LGEDSDYDKLSDMVKYLDLELHFGTQKPAK-----PVPGPEPFRKKEV-VEILSHKKAYNTSILL 907

  Fly   700 GGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATI 764
             ..|| ||..:::..|:..:...|....|.||:.:.|..:..:|.|..:.....|...:||...:
Human   908 -AHLK-LSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQM 970

  Fly   765 GEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGS- 828
            ..:.....||.:|:|:.|..:..::|:..:.....|..|::||:|.:||||.:|.:|||:|.|. 
Human   971 LSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQP 1035

  Fly   829 KNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQ 893
            |.....||:|::||:|::||..|.|.|.||.||..:.:.||:.|.|..||..|..|::||..|:.
Human  1036 KTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALT 1100

  Fly   894 KAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQ-MEKLYKDLSE 957
            ..:..::..:..::...|:  :....:|||:.||..|.|..:..:..|..:|.: ||:|.|.|: 
Human  1101 SDLADLHGTISEIQDACQS--ISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALA- 1162

  Fly   958 YYAFDPSKYTMEEFFADIKTFKDAFQAAHND 988
            ::..|....|.|.||.....|...|:.|.:|
Human  1163 FFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:461886
Drf_FH3 253..453 CDD:461885
FH2 608..983 CDD:396655 109/381 (29%)
GRID2IPNP_001138590.1 PDZ1_L-delphilin-like 7..82 CDD:467225
HN_L-delphilin-R1_like 133..212 CDD:259820
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269
PDZ2_L-delphilin-like 279..353 CDD:467226
HN_L-delphilin-R2_like 389..468 CDD:259821
PHA03307 475..>679 CDD:223039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783 13/38 (34%)
FH2 820..1188 CDD:396655 109/381 (29%)
Blue background indicates that the domain is not in the aligned region.

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