Protein Alignment dia and Diaph2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001414307.1
• Gene: Diaph2 / 317189
• RGDID: 1564399
• Length: 1101
• Species: Rattus norvegicus
• Alignment Length: 1097
• Identity: 419/1097 - (38%)
• Similarity: 640/1097 - (58%)
• Gaps: 104/1097 - (9%)

  Fly    25 LFGRPSKSKG--GTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNI 87
            |...|:.|:.  |.:.|..:.|..|.:.                  ||..|:...|.:::||||:
  Rat    75 LIQHPTDSQAAMGEVPSAQILHDERSLI------------------LSEKEVLDLFEKMMEDMNL 121

  Fly    88 PKDKREPLLAKSKEERQKMIMWHLK-------GKNSLERSANSRFEKPI---DYVEYLQNGEHST 142
            .::|:.||..|....:::|::.::.       |...:....|::.|..:   :||..|::| .|.
  Rat   122 NEEKKAPLRDKDFTTKREMVVQYISATAKSIVGSKVMGGLKNNKHEFTLSSQEYVHELRSG-ISD 185

  Fly   143 HKVYQCVESLRVALTSNPISWIKEFGVAGIG----TIEKLLARSKNNASYEKIEFEAIRCLKAIM 203
            .|:..|:|||||:|||||:||:..||..|:|    .:||||.:.:.....:|.:::.|:||||.|
  Rat   186 EKLLNCLESLRVSLTSNPVSWVNNFGYEGLGVLLDVLEKLLDKKQQENIDKKNQYKIIQCLKAFM 250

  Fly   204 NNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAAT 268
            ||.:||..:|. |:.| :||||:::||::...|.|.:|:|::.|||.|.|..:|:|..||  ||.
  Rat   251 NNKFGLQRILG-DERS-LLLLARAIDPKQQNMMTEIVKILSAICIVGEENILDKLLGGIT--AAA 311

  Fly   269 SFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLD 333
            .....|||.|||:.|  .:.:.....:||  :.|||.|..:|.||:||:|||.|.:|.||...|.
  Rat   312 ERNNRERFSPIVEGL--ENNEALHLQVAC--MQFINALVTSPYDLDFRIHLRNEFLRCGLKAMLP 372

  Fly   334 EFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPY 398
            .    ::...|:.|....::|.|.:|||..|...|.:::...|||..:.|.:|.|::.||.:|.|
  Rat   373 S----LKEKENDELDIQLRVFEENKEDDLTELSHRLNDIRAEMDDMNEVFHLLYNMLKDTAAEGY 433

  Fly   399 FLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENR-NFNIDTSLLLDDIVEKAK 462
            .||||||.|.||:|:|.||.||::||||:||||.|....||:|:.| ..:.|.:.|:|..|.|||
  Rat   434 LLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRIDFDFTHLIDACVNKAK 498

  Fly   463 AKES-KRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLME-------ANGVAAPSPNKLPKVNIP 519
            .:|| :::.|:.||.::..:|:|||:|:....:||:|.:|       |.|
  Rat   499 VEESEQKAMEFSKKFDEEFTARQEAQAEIQKRDEKIKELESEIQQLQAQG--------------- 548

  Fly   520 MPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRP 584
                 ||.....||||||:||.....||||||||:||  .|||||||.||. .|||||:
  Rat   549 -----PGSAFPGPPPPPPLPGAGPCPPPPPPPPPLPG--VGPPPPPPLPGT-APPPPPL------ 599

  Fly   585 GGGP--PPPPMMMGPMVP---VLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDK 644
            .|.|  ||||..:.|.:|   .||:|:|.||.::.:..|||.||..|.|..:|:...|:|.:|:|
  Rat   600 FGAPLLPPPPGGITPSLPGPVELPYGMKQKKLYNPEVSMKRINWSKIEPRDLSENCVWLKLKEEK 664

  Fly   645 LAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTL---TKKNVDLRVLDSKTAQNLAIMLGGSLKHL 706
            ....|..|:||:.|.|: :|.::.....:...:   .||..:||:||:||||||:|.||.  ..:
  Rat   665 YENPDLFAKLALTFPSQ-MKGQRHGETSEENRIGPQKKKMKELRILDTKTAQNLSIFLGS--YRM 726

  Fly   707 SYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLS 771
            .||:||..:|..:.::||..::|.|::|||....|:.|.::|.:.:.|...|||...:..:..|.
  Rat   727 PYEEIKNIILEVNEELLSEALIQNLVKYLPEQNVLRELAQLKNEYDDLCEPEQFGVVMSTVNMLR 791

  Fly   772 PRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGF 836
            |||.::.||||:.:.|.:|||.|:|.|.||||::.|:.|:::||||||:||||||||:|..:.||
  Rat   792 PRLTSILFKLTFEEHVNNIKPSIIAVTLACEELKKSESFNRLLELILLVGNYMNSGSRNAQSLGF 856

  Fly   837 EISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNS 901
            :|::|.|:.:||.||.|.||||:||::.:::..|.|.|.::|.||..||:|:...::..:..|..
  Rat   857 KINFLCKIKDTKSADQKTTLLHFLAEICDEQHRDILKFPEELEHVESASKVSAQILKSNLVAMEQ 921

  Fly   902 AVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKY 966
            ::.:||::::|....:...|||.|.|..|.:..|:|.|.|..|...|.|||:.|.||:.|||:..
  Rat   922 SILHLESNIKNFPKAESLHDKFVEKMMSFTQNAREQYDKLSTMHSNMLKLYESLGEYFIFDPNIV 986

  Fly   967 TMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQT 1031
            |:||||.|:.||:..|..|..:|.:.:|..||.||.:.|:|::.:|:.|||::||.::|::....
  Rat   987 TIEEFFGDLNTFRTLFLEALKENHKRKEMEEKSRRAKLAKEKAEQEKLERQKKKKQLIDINKEGD 1051

  Fly  1032 QEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAE-RRAQLSRSRSRTRVTNGQLMTR 1087
            :.||||:||||||:|:||    |..|::.|...: ||..|.|||||   .||.:.::
  Rat  1052 ETGVMDNLLEALQSGAAF----RDRRKRIPRNPDNRRPTLERSRSR---HNGAMPSK 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	67/195 (34%)
		Drf_FH3	253..453	CDD:461885	81/200 (41%)
		FH2	608..983	CDD:396655	149/377 (40%)
Diaph2	NP_001414307.1	None